Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer’s Disease Dementia

The purpose of this study was to investigate whether brain and cognitive reserves were associated with the clinical progression of AD dementia. We included participants with AD dementia from the Alzheimer’s Disease Neuroimaging Initiative, provided they were followed up at least once, and candidate...

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Autores principales:	Hyung-Jun Yoon, Seung-Gon Kim, Sang Hoon Kim, Jong Inn Woo, Eun Hyun Seo, For the Alzheimer’s Disease Neuroimaing Initiative
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Alzheimer’s disease dementia cognitive reserve brain reserve clinical progression cerebral glucose metabolism Medicine R
Acceso en línea:	https://doaj.org/article/b07a259944f247c59587c34f2a77624f
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spelling	oai:doaj.org-article:b07a259944f247c59587c34f2a77624f2021-11-25T17:51:35ZAssociations between Brain Reserve Proxies and Clinical Progression in Alzheimer’s Disease Dementia10.3390/ijerph1822121591660-46011661-7827https://doaj.org/article/b07a259944f247c59587c34f2a77624f2021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/22/12159https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601The purpose of this study was to investigate whether brain and cognitive reserves were associated with the clinical progression of AD dementia. We included participants with AD dementia from the Alzheimer’s Disease Neuroimaging Initiative, provided they were followed up at least once, and candidate proxies for cognitive (education for early-life reserve and Adult Reading Test for late-life reserve) or brain reserve (intracranial volume [ICV] for early-life reserve and the composite value of [<sup>18</sup>F] fluorodeoxyglucose positron emission tomography regions of interest (FDG-ROIs) for late-life reserve) were available. The final analysis included 120 participants. Cox proportional hazards model revealed that FDG-ROIs were the only significant predictor of clinical progression. Subgroup analysis revealed a significant association between FDG-ROIs and clinical progression only in the larger ICV group (HR = 0.388, <i>p</i> = 0.028, 95% CI 0.167–0.902). Our preliminary findings suggest that relatively preserved cerebral glucose metabolism might delay further clinical progression in AD dementia, particularly in the greater ICV group. In addition to ICV, cerebral glucose metabolism could play an important role as a late-life brain reserve in the process of neurodegeneration. Distinguishing between early- and late-life reserves, and considering both proxies simultaneously, would provide a wider range of factors associated with the prognosis of AD dementia.Hyung-Jun YoonSeung-Gon KimSang Hoon KimJong Inn WooEun Hyun SeoFor the Alzheimer’s Disease Neuroimaing InitiativeMDPI AGarticleAlzheimer’s diseasedementiacognitive reservebrain reserveclinical progressioncerebral glucose metabolismMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 12159, p 12159 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease dementia cognitive reserve brain reserve clinical progression cerebral glucose metabolism Medicine R
spellingShingle	Alzheimer’s disease dementia cognitive reserve brain reserve clinical progression cerebral glucose metabolism Medicine R Hyung-Jun Yoon Seung-Gon Kim Sang Hoon Kim Jong Inn Woo Eun Hyun Seo For the Alzheimer’s Disease Neuroimaing Initiative Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer’s Disease Dementia
description	The purpose of this study was to investigate whether brain and cognitive reserves were associated with the clinical progression of AD dementia. We included participants with AD dementia from the Alzheimer’s Disease Neuroimaging Initiative, provided they were followed up at least once, and candidate proxies for cognitive (education for early-life reserve and Adult Reading Test for late-life reserve) or brain reserve (intracranial volume [ICV] for early-life reserve and the composite value of [<sup>18</sup>F] fluorodeoxyglucose positron emission tomography regions of interest (FDG-ROIs) for late-life reserve) were available. The final analysis included 120 participants. Cox proportional hazards model revealed that FDG-ROIs were the only significant predictor of clinical progression. Subgroup analysis revealed a significant association between FDG-ROIs and clinical progression only in the larger ICV group (HR = 0.388, <i>p</i> = 0.028, 95% CI 0.167–0.902). Our preliminary findings suggest that relatively preserved cerebral glucose metabolism might delay further clinical progression in AD dementia, particularly in the greater ICV group. In addition to ICV, cerebral glucose metabolism could play an important role as a late-life brain reserve in the process of neurodegeneration. Distinguishing between early- and late-life reserves, and considering both proxies simultaneously, would provide a wider range of factors associated with the prognosis of AD dementia.
format	article
author	Hyung-Jun Yoon Seung-Gon Kim Sang Hoon Kim Jong Inn Woo Eun Hyun Seo For the Alzheimer’s Disease Neuroimaing Initiative
author_facet	Hyung-Jun Yoon Seung-Gon Kim Sang Hoon Kim Jong Inn Woo Eun Hyun Seo For the Alzheimer’s Disease Neuroimaing Initiative
author_sort	Hyung-Jun Yoon
title	Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer’s Disease Dementia
title_short	Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer’s Disease Dementia
title_full	Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer’s Disease Dementia
title_fullStr	Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer’s Disease Dementia
title_full_unstemmed	Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer’s Disease Dementia
title_sort	associations between brain reserve proxies and clinical progression in alzheimer’s disease dementia
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b07a259944f247c59587c34f2a77624f
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Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer’s Disease Dementia

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