Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair

DNA double-strand break (DSB) repair is a tightly regulated process that can occur via non-homologous end joining (NHEJ) or homologous recombination (HR). Here, the authors investigate how RECQL4 modulates DSB repair pathway choice by differentially regulating NHEJ and HR in a cell cycle-dependent m...

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Autores principales:	Huiming Lu, Raghavendra A. Shamanna, Jessica K. de Freitas, Mustafa Okur, Prabhat Khadka, Tomasz Kulikowicz, Priscella P. Holland, Jane Tian, Deborah L. Croteau, Anthony J. Davis, Vilhelm A. Bohr
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b07af637d9dc41b1aa40bd124f2fae2c
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spelling	oai:doaj.org-article:b07af637d9dc41b1aa40bd124f2fae2c2021-12-02T17:06:21ZCell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair10.1038/s41467-017-02146-32041-1723https://doaj.org/article/b07af637d9dc41b1aa40bd124f2fae2c2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02146-3https://doaj.org/toc/2041-1723DNA double-strand break (DSB) repair is a tightly regulated process that can occur via non-homologous end joining (NHEJ) or homologous recombination (HR). Here, the authors investigate how RECQL4 modulates DSB repair pathway choice by differentially regulating NHEJ and HR in a cell cycle-dependent manner.Huiming LuRaghavendra A. ShamannaJessica K. de FreitasMustafa OkurPrabhat KhadkaTomasz KulikowiczPriscella P. HollandJane TianDeborah L. CroteauAnthony J. DavisVilhelm A. BohrNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huiming Lu Raghavendra A. Shamanna Jessica K. de Freitas Mustafa Okur Prabhat Khadka Tomasz Kulikowicz Priscella P. Holland Jane Tian Deborah L. Croteau Anthony J. Davis Vilhelm A. Bohr Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair
description	DNA double-strand break (DSB) repair is a tightly regulated process that can occur via non-homologous end joining (NHEJ) or homologous recombination (HR). Here, the authors investigate how RECQL4 modulates DSB repair pathway choice by differentially regulating NHEJ and HR in a cell cycle-dependent manner.
format	article
author	Huiming Lu Raghavendra A. Shamanna Jessica K. de Freitas Mustafa Okur Prabhat Khadka Tomasz Kulikowicz Priscella P. Holland Jane Tian Deborah L. Croteau Anthony J. Davis Vilhelm A. Bohr
author_facet	Huiming Lu Raghavendra A. Shamanna Jessica K. de Freitas Mustafa Okur Prabhat Khadka Tomasz Kulikowicz Priscella P. Holland Jane Tian Deborah L. Croteau Anthony J. Davis Vilhelm A. Bohr
author_sort	Huiming Lu
title	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair
title_short	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair
title_full	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair
title_fullStr	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair
title_full_unstemmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair
title_sort	cell cycle-dependent phosphorylation regulates recql4 pathway choice and ubiquitination in dna double-strand break repair
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b07af637d9dc41b1aa40bd124f2fae2c
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Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair

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