Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair

QR Code

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair

DNA double-strand break (DSB) repair is a tightly regulated process that can occur via non-homologous end joining (NHEJ) or homologous recombination (HR). Here, the authors investigate how RECQL4 modulates DSB repair pathway choice by differentially regulating NHEJ and HR in a cell cycle-dependent m...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Huiming Lu, Raghavendra A. Shamanna, Jessica K. de Freitas, Mustafa Okur, Prabhat Khadka, Tomasz Kulikowicz, Priscella P. Holland, Jane Tian, Deborah L. Croteau, Anthony J. Davis, Vilhelm A. Bohr
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/b07af637d9dc41b1aa40bd124f2fae2c
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

WRN regulates pathway choice between classical and alternative non-homologous end joining
par: Raghavendra A. Shamanna, et autres
Publié: (2016)

Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks
par: Geun-Hyoung Ha, et autres
Publié: (2019)

DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner
par: Patrick L. Collins, et autres
Publié: (2020)

DNA double strand break position leads to distinct gene expression changes and regulates VSG switching pathway choice.
par: Alix Thivolle, et autres
Publié: (2021)

A scalable CRISPR/Cas9-based fluorescent reporter assay to study DNA double-strand break repair choice
par: Paris Roidos, et autres
Publié: (2020)

Inactivation of nuclear GSK3β by Ser389 phosphorylation promotes lymphocyte fitness during DNA double-strand break response
par: Tina M. Thornton, et autres
Publié: (2016)

A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice
par: Haoxing Zhang, et autres
Publié: (2016)

Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae.
par: Yong Yang, et autres
Publié: (2008)

BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks
par: Winston X. Yan, et autres
Publié: (2017)

Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair
par: Joonas A. Jamsen, et autres
Publié: (2021)

Mechanistic Insights From Single-Molecule Studies of Repair of Double Strand Breaks
par: Muwen Kong, et autres
Publié: (2021)

Replication stress induces micronuclei comprising of aggregated DNA double-strand breaks.
par: Bing Xu, et autres
Publié: (2011)

An OB-fold complex controls the repair pathways for DNA double-strand breaks
par: Shengxian Gao, et autres
Publié: (2018)

Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase
par: Zhaofeng Ye, et autres
Publié: (2017)

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
par: Marie-Christine Caron, et autres
Publié: (2019)

Time-lapse crystallography snapshots of a double-strand break repair polymerase in action
par: Joonas A. Jamsen, et autres
Publié: (2017)

Repair of DNA strand breaks in a minichromosome in vivo: kinetics, modeling, and effects of inhibitors.
par: Slawomir Kumala, et autres
Publié: (2013)

Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks
par: Pauline Chanut, et autres
Publié: (2016)

DNA single-strand break-induced DNA damage response causes heart failure
par: Tomoaki Higo, et autres
Publié: (2017)

Recognition of double strand breaks by a mutator protein (MU2) in Drosophila melanogaster.
par: Raghuvar Dronamraju, et autres
Publié: (2009)

An Induced Mutation in HvRECQL4 Increases the Overall Recombination and Restores Fertility in a Barley HvMLH3 Mutant Background
par: Mikel Arrieta, et autres
Publié: (2021)

Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome
par: Mustafa N. Okur, et autres
Publié: (2020)

Regulation of reactive oxygen species during plant immunity through phosphorylation and ubiquitination of RBOHD
par: DongHyuk Lee, et autres
Publié: (2020)

Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions
par: Örjan Persson, et autres
Publié: (2019)

UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair
par: Greg H. P. Ngo, et autres
Publié: (2021)

Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane
par: Gabriele A. Fontana, et autres
Publié: (2019)

Phenotypic diversification by enhanced genome restructuring after induction of multiple DNA double-strand breaks
par: Nobuhiko Muramoto, et autres
Publié: (2018)

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations
par: Sarah Cohen, et autres
Publié: (2018)

RIF1 Links Replication Timing with Fork Reactivation and DNA Double-Strand Break Repair
par: Janusz Blasiak, et autres
Publié: (2021)

Alternative Lengthening of Telomeres: Lessons to Be Learned from Telomeric DNA Double-Strand Break Repair
par: Thomas Kent, et autres
Publié: (2021)

Essential factors for incompatible DNA end joining at chromosomal DNA double strand breaks in vivo.
par: Hideaki Ogiwara, et autres
Publié: (2011)

Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
par: Joe Nassour, et autres
Publié: (2016)

FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku
par: Hanyong Jin, et autres
Publié: (2020)

Structural snapshots of human DNA polymerase μ engaged on a DNA double-strand break
par: Andrea M. Kaminski, et autres
Publié: (2020)

DNA double-strand breaks in telophase lead to coalescence between segregated sister chromatid loci
par: Jessel Ayra-Plasencia, et autres
Publié: (2019)

Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break
par: Jieqiong Lou, et autres
Publié: (2020)

Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions
par: James M. Daley, et autres
Publié: (2020)

Distribution of Holliday junctions and repair forks during Escherichia coli DNA double-strand break repair.
par: Tahirah Yasmin, et autres
Publié: (2021)

DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
par: Hiro Sato, et autres
Publié: (2017)

Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide
par: Joonas A. Jamsen, et autres
Publié: (2021)