Use of Deoxycorticosterone Pivalate by Veterinarians: A Western European Survey

This study aims to gather knowledge about the use of deoxycorticosterone pivalate (DOCP) by Western European Veterinarians (WEV) in dogs with typical hypoadrenocorticism. An observational cross-sectional study was conducted using an online survey, translated into four languages and disseminated to v...

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Autores principales:	Rita Rebocho, Marina Domínguez-Ruiz, Ryane E. Englar, Carolina Arenas, Maria Dolores Pérez-Alenza, Andrea Corsini, Federico Fracassi, Michael Bennaim, Rodolfo Oliveira Leal
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	DOCP hypoadrenocorticism deoxycorticosterone pivalate fludrocortisone Europe Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/b0857e7b0cb24cd1a1e1ca12a4c1e161
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spelling	oai:doaj.org-article:b0857e7b0cb24cd1a1e1ca12a4c1e1612021-11-25T19:12:03ZUse of Deoxycorticosterone Pivalate by Veterinarians: A Western European Survey10.3390/vetsci81102712306-7381https://doaj.org/article/b0857e7b0cb24cd1a1e1ca12a4c1e1612021-11-01T00:00:00Zhttps://www.mdpi.com/2306-7381/8/11/271https://doaj.org/toc/2306-7381This study aims to gather knowledge about the use of deoxycorticosterone pivalate (DOCP) by Western European Veterinarians (WEV) in dogs with typical hypoadrenocorticism. An observational cross-sectional study was conducted using an online survey, translated into four languages and disseminated to veterinary affiliates and mailing lists in six countries of Western Continental Europe. Respondents were tasked to share their therapeutic approach to hypoadrenocorticism, whether they preferred DOCP or fludrocortisone and the specific practical use of DOCP. One-hundred and eighty-four responses were included. Of these, 79.9% indicated that they preferred prescribing DOCP over fludrocortisone as a first-line treatment for mineralocorticoid supplementation. A total of 154 respondents had used DOCP at least once. Eighty percent of those who reported their initial dosage prescribed 2.2 mg/kg. After starting DOCP, 68.2% of the respondents assess electrolytes 10 and 25 days after administration following manufacturer instructions. In stable dogs, electrolytes are monitored quarterly, monthly, semi-annually, and annually by 44.2%, 34.4%, 16.9%, and 4.6% of respondents respectively. When treatment adjustment is required, 53% prefer to reduce dosage while 47% increase the interval between doses. Overall, DOCP is the preferred mineralocorticoid supplementation among WEV. Reported variability underlies the need to investigate the best strategies for DOCP use and therapeutic adjustments.Rita RebochoMarina Domínguez-RuizRyane E. EnglarCarolina ArenasMaria Dolores Pérez-AlenzaAndrea CorsiniFederico FracassiMichael BennaimRodolfo Oliveira LealMDPI AGarticleDOCPhypoadrenocorticismdeoxycorticosterone pivalatefludrocortisoneEuropeVeterinary medicineSF600-1100ENVeterinary Sciences, Vol 8, Iss 271, p 271 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	DOCP hypoadrenocorticism deoxycorticosterone pivalate fludrocortisone Europe Veterinary medicine SF600-1100
spellingShingle	DOCP hypoadrenocorticism deoxycorticosterone pivalate fludrocortisone Europe Veterinary medicine SF600-1100 Rita Rebocho Marina Domínguez-Ruiz Ryane E. Englar Carolina Arenas Maria Dolores Pérez-Alenza Andrea Corsini Federico Fracassi Michael Bennaim Rodolfo Oliveira Leal Use of Deoxycorticosterone Pivalate by Veterinarians: A Western European Survey
description	This study aims to gather knowledge about the use of deoxycorticosterone pivalate (DOCP) by Western European Veterinarians (WEV) in dogs with typical hypoadrenocorticism. An observational cross-sectional study was conducted using an online survey, translated into four languages and disseminated to veterinary affiliates and mailing lists in six countries of Western Continental Europe. Respondents were tasked to share their therapeutic approach to hypoadrenocorticism, whether they preferred DOCP or fludrocortisone and the specific practical use of DOCP. One-hundred and eighty-four responses were included. Of these, 79.9% indicated that they preferred prescribing DOCP over fludrocortisone as a first-line treatment for mineralocorticoid supplementation. A total of 154 respondents had used DOCP at least once. Eighty percent of those who reported their initial dosage prescribed 2.2 mg/kg. After starting DOCP, 68.2% of the respondents assess electrolytes 10 and 25 days after administration following manufacturer instructions. In stable dogs, electrolytes are monitored quarterly, monthly, semi-annually, and annually by 44.2%, 34.4%, 16.9%, and 4.6% of respondents respectively. When treatment adjustment is required, 53% prefer to reduce dosage while 47% increase the interval between doses. Overall, DOCP is the preferred mineralocorticoid supplementation among WEV. Reported variability underlies the need to investigate the best strategies for DOCP use and therapeutic adjustments.
format	article
author	Rita Rebocho Marina Domínguez-Ruiz Ryane E. Englar Carolina Arenas Maria Dolores Pérez-Alenza Andrea Corsini Federico Fracassi Michael Bennaim Rodolfo Oliveira Leal
author_facet	Rita Rebocho Marina Domínguez-Ruiz Ryane E. Englar Carolina Arenas Maria Dolores Pérez-Alenza Andrea Corsini Federico Fracassi Michael Bennaim Rodolfo Oliveira Leal
author_sort	Rita Rebocho
title	Use of Deoxycorticosterone Pivalate by Veterinarians: A Western European Survey
title_short	Use of Deoxycorticosterone Pivalate by Veterinarians: A Western European Survey
title_full	Use of Deoxycorticosterone Pivalate by Veterinarians: A Western European Survey
title_fullStr	Use of Deoxycorticosterone Pivalate by Veterinarians: A Western European Survey
title_full_unstemmed	Use of Deoxycorticosterone Pivalate by Veterinarians: A Western European Survey
title_sort	use of deoxycorticosterone pivalate by veterinarians: a western european survey
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b0857e7b0cb24cd1a1e1ca12a4c1e161
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Use of Deoxycorticosterone Pivalate by Veterinarians: A Western European Survey

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