Fibrinogen function achieved through multiple covalent states

Disulfide bonds play critical roles in determining protein structure and function. Here, the authors show that fibrinogen exists in multiple disulfide-bonded states in human blood, and that these states change during fibrin polymerization and in response to fluid shear forces.

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Bibliographic Details
Main Authors:	Diego Butera, Philip J. Hogg
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/b08a8ba494e34f3294f59b0d5edbc4d5
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spelling	oai:doaj.org-article:b08a8ba494e34f3294f59b0d5edbc4d52021-12-02T14:41:23ZFibrinogen function achieved through multiple covalent states10.1038/s41467-020-19295-72041-1723https://doaj.org/article/b08a8ba494e34f3294f59b0d5edbc4d52020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19295-7https://doaj.org/toc/2041-1723Disulfide bonds play critical roles in determining protein structure and function. Here, the authors show that fibrinogen exists in multiple disulfide-bonded states in human blood, and that these states change during fibrin polymerization and in response to fluid shear forces.Diego ButeraPhilip J. HoggNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Diego Butera Philip J. Hogg Fibrinogen function achieved through multiple covalent states
description	Disulfide bonds play critical roles in determining protein structure and function. Here, the authors show that fibrinogen exists in multiple disulfide-bonded states in human blood, and that these states change during fibrin polymerization and in response to fluid shear forces.
format	article
author	Diego Butera Philip J. Hogg
author_facet	Diego Butera Philip J. Hogg
author_sort	Diego Butera
title	Fibrinogen function achieved through multiple covalent states
title_short	Fibrinogen function achieved through multiple covalent states
title_full	Fibrinogen function achieved through multiple covalent states
title_fullStr	Fibrinogen function achieved through multiple covalent states
title_full_unstemmed	Fibrinogen function achieved through multiple covalent states
title_sort	fibrinogen function achieved through multiple covalent states
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b08a8ba494e34f3294f59b0d5edbc4d5
work_keys_str_mv	AT diegobutera fibrinogenfunctionachievedthroughmultiplecovalentstates AT philipjhogg fibrinogenfunctionachievedthroughmultiplecovalentstates
_version_	1718389892080205824

Fibrinogen function achieved through multiple covalent states

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