Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect

The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administrati...

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Autores principales:	María Dolores Rodríguez-Pérez, Juan Antonio López-Villodres, María Monsalud Arrebola, Esther Martín-Aurioles, África Fernández-Prior, Alejandra Bermúdez-Oria, María Carmen Ríos, José Pedro De La Cruz, José Antonio González-Correa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hydroxytyrosol diabetes nephropathy virgin olive oil Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/b08b9c23e6194fb8abfcbdfb40ea79c8
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spelling	oai:doaj.org-article:b08b9c23e6194fb8abfcbdfb40ea79c82021-11-25T16:28:32ZNephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect10.3390/antiox101117832076-3921https://doaj.org/article/b08b9c23e6194fb8abfcbdfb40ea79c82021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1783https://doaj.org/toc/2076-3921The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67–73%), calculated creatinine clearance was significantly increased (26–38%), and the glomerular volume and glomerulosclerosis index were decreased (20–30%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg/kg/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production.María Dolores Rodríguez-PérezJuan Antonio López-VillodresMaría Monsalud ArrebolaEsther Martín-AuriolesÁfrica Fernández-PriorAlejandra Bermúdez-OriaMaría Carmen RíosJosé Pedro De La CruzJosé Antonio González-CorreaMDPI AGarticlehydroxytyrosoldiabetesnephropathyvirgin olive oilTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1783, p 1783 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hydroxytyrosol diabetes nephropathy virgin olive oil Therapeutics. Pharmacology RM1-950
spellingShingle	hydroxytyrosol diabetes nephropathy virgin olive oil Therapeutics. Pharmacology RM1-950 María Dolores Rodríguez-Pérez Juan Antonio López-Villodres María Monsalud Arrebola Esther Martín-Aurioles África Fernández-Prior Alejandra Bermúdez-Oria María Carmen Ríos José Pedro De La Cruz José Antonio González-Correa Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect
description	The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67–73%), calculated creatinine clearance was significantly increased (26–38%), and the glomerular volume and glomerulosclerosis index were decreased (20–30%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg/kg/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production.
format	article
author	María Dolores Rodríguez-Pérez Juan Antonio López-Villodres María Monsalud Arrebola Esther Martín-Aurioles África Fernández-Prior Alejandra Bermúdez-Oria María Carmen Ríos José Pedro De La Cruz José Antonio González-Correa
author_facet	María Dolores Rodríguez-Pérez Juan Antonio López-Villodres María Monsalud Arrebola Esther Martín-Aurioles África Fernández-Prior Alejandra Bermúdez-Oria María Carmen Ríos José Pedro De La Cruz José Antonio González-Correa
author_sort	María Dolores Rodríguez-Pérez
title	Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect
title_short	Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect
title_full	Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect
title_fullStr	Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect
title_full_unstemmed	Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect
title_sort	nephroprotective effect of the virgin olive oil polyphenol hydroxytyrosol in type 1-like experimental diabetes mellitus: relationships with its antioxidant effect
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b08b9c23e6194fb8abfcbdfb40ea79c8
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Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect

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