Bacterial Outer Membrane Vesicles as a Versatile Tool in Vaccine Research and the Fight against Antimicrobial Resistance

ABSTRACT Gram-negative bacteria include a number of pathogens that cause disease in humans and animals. Although antibiotics are still effective in treating a considerable range of infections caused by Gram-negative bacteria, the alarming increase of antimicrobial resistance (AMR) induced by excessi...

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Autores principales:	Zhuang Zhu, Fabio Antenucci, Kasper Rømer Villumsen, Anders Miki Bojesen
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	antimicrobial resistance bacterial outer membrane vesicles vaccine Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b095ef4856814a3598f89c21329ac1dd
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spelling	oai:doaj.org-article:b095ef4856814a3598f89c21329ac1dd2021-11-10T18:37:52ZBacterial Outer Membrane Vesicles as a Versatile Tool in Vaccine Research and the Fight against Antimicrobial Resistance10.1128/mBio.01707-212150-7511https://doaj.org/article/b095ef4856814a3598f89c21329ac1dd2021-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01707-21https://doaj.org/toc/2150-7511ABSTRACT Gram-negative bacteria include a number of pathogens that cause disease in humans and animals. Although antibiotics are still effective in treating a considerable range of infections caused by Gram-negative bacteria, the alarming increase of antimicrobial resistance (AMR) induced by excessive use of antibiotics has raised global concerns. Therefore, alternative strategies must be developed to prevent and treat bacterial infections and prevent the advent of a postantibiotic era. Vaccines, one of the greatest achievements in the history of medical science, hold extraordinary potential to prevent bacterial infections and thereby reduce the need for antibiotics. Novel bacterial vaccines are urgently needed, however, and outer membrane vesicles (OMVs), naturally produced by Gram-negative bacteria, represent a promising and versatile tool that can be employed as adjuvants, antigens, and delivery platforms in the development of vaccines against Gram-negative bacteria. Here, we provide an overview of the many roles OMVs can play in vaccine development and the mechanisms behind these applications. Methods to improve OMV yields and a comparison of different strategies for OMV isolation aiming at cost-effective production of OMV-based vaccines are also reviewed.Zhuang ZhuFabio AntenucciKasper Rømer VillumsenAnders Miki BojesenAmerican Society for Microbiologyarticleantimicrobial resistancebacterial outer membrane vesiclesvaccineMicrobiologyQR1-502ENmBio, Vol 12, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antimicrobial resistance bacterial outer membrane vesicles vaccine Microbiology QR1-502
spellingShingle	antimicrobial resistance bacterial outer membrane vesicles vaccine Microbiology QR1-502 Zhuang Zhu Fabio Antenucci Kasper Rømer Villumsen Anders Miki Bojesen Bacterial Outer Membrane Vesicles as a Versatile Tool in Vaccine Research and the Fight against Antimicrobial Resistance
description	ABSTRACT Gram-negative bacteria include a number of pathogens that cause disease in humans and animals. Although antibiotics are still effective in treating a considerable range of infections caused by Gram-negative bacteria, the alarming increase of antimicrobial resistance (AMR) induced by excessive use of antibiotics has raised global concerns. Therefore, alternative strategies must be developed to prevent and treat bacterial infections and prevent the advent of a postantibiotic era. Vaccines, one of the greatest achievements in the history of medical science, hold extraordinary potential to prevent bacterial infections and thereby reduce the need for antibiotics. Novel bacterial vaccines are urgently needed, however, and outer membrane vesicles (OMVs), naturally produced by Gram-negative bacteria, represent a promising and versatile tool that can be employed as adjuvants, antigens, and delivery platforms in the development of vaccines against Gram-negative bacteria. Here, we provide an overview of the many roles OMVs can play in vaccine development and the mechanisms behind these applications. Methods to improve OMV yields and a comparison of different strategies for OMV isolation aiming at cost-effective production of OMV-based vaccines are also reviewed.
format	article
author	Zhuang Zhu Fabio Antenucci Kasper Rømer Villumsen Anders Miki Bojesen
author_facet	Zhuang Zhu Fabio Antenucci Kasper Rømer Villumsen Anders Miki Bojesen
author_sort	Zhuang Zhu
title	Bacterial Outer Membrane Vesicles as a Versatile Tool in Vaccine Research and the Fight against Antimicrobial Resistance
title_short	Bacterial Outer Membrane Vesicles as a Versatile Tool in Vaccine Research and the Fight against Antimicrobial Resistance
title_full	Bacterial Outer Membrane Vesicles as a Versatile Tool in Vaccine Research and the Fight against Antimicrobial Resistance
title_fullStr	Bacterial Outer Membrane Vesicles as a Versatile Tool in Vaccine Research and the Fight against Antimicrobial Resistance
title_full_unstemmed	Bacterial Outer Membrane Vesicles as a Versatile Tool in Vaccine Research and the Fight against Antimicrobial Resistance
title_sort	bacterial outer membrane vesicles as a versatile tool in vaccine research and the fight against antimicrobial resistance
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/b095ef4856814a3598f89c21329ac1dd
work_keys_str_mv	AT zhuangzhu bacterialoutermembranevesiclesasaversatiletoolinvaccineresearchandthefightagainstantimicrobialresistance AT fabioantenucci bacterialoutermembranevesiclesasaversatiletoolinvaccineresearchandthefightagainstantimicrobialresistance AT kasperrømervillumsen bacterialoutermembranevesiclesasaversatiletoolinvaccineresearchandthefightagainstantimicrobialresistance AT andersmikibojesen bacterialoutermembranevesiclesasaversatiletoolinvaccineresearchandthefightagainstantimicrobialresistance
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Bacterial Outer Membrane Vesicles as a Versatile Tool in Vaccine Research and the Fight against Antimicrobial Resistance

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