First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil

Abstract The Brazilian regions are still highly endemic areas for Canine morbillivirus [canine distemper virus (CDV)]. However, little is known regarding the genetic variability of the strain circulating in several Brazilian regions. Here, we report the first full-length genome and molecular charact...

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Autores principales:	Vivaldo Gomes da Costa, Marielena Vogel Saivish, Priscila Gomes de Oliveira, Abelardo Silva-Júnior, Marcos Lázaro Moreli, Ricardo Henrique Krüger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b0961c1707184499a667769a98a4e4ca
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spelling	oai:doaj.org-article:b0961c1707184499a667769a98a4e4ca2021-12-02T18:02:49ZFirst complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil10.1038/s41598-021-92183-22045-2322https://doaj.org/article/b0961c1707184499a667769a98a4e4ca2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92183-2https://doaj.org/toc/2045-2322Abstract The Brazilian regions are still highly endemic areas for Canine morbillivirus [canine distemper virus (CDV)]. However, little is known regarding the genetic variability of the strain circulating in several Brazilian regions. Here, we report the first full-length genome and molecular characterization of CDV isolated from domestic dogs in the Brazilian Center-West region. Sequence alignment and phylogenetic analyses based on deduced amino acid and nucleotide sequences showed that the isolated strain is characterized as the South America-I/Europe genotype. However, it segregates into a CDV subgenotype branch. Interestingly, both H and F proteins have a gain of a potential N-glycosylation sites compared to the Onderstepoort vaccine strain. Therefore, this study provides a reference to further understand the epidemic and molecular characteristics of the CDV in Brazil.Vivaldo Gomes da CostaMarielena Vogel SaivishPriscila Gomes de OliveiraAbelardo Silva-JúniorMarcos Lázaro MoreliRicardo Henrique KrügerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vivaldo Gomes da Costa Marielena Vogel Saivish Priscila Gomes de Oliveira Abelardo Silva-Júnior Marcos Lázaro Moreli Ricardo Henrique Krüger First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil
description	Abstract The Brazilian regions are still highly endemic areas for Canine morbillivirus [canine distemper virus (CDV)]. However, little is known regarding the genetic variability of the strain circulating in several Brazilian regions. Here, we report the first full-length genome and molecular characterization of CDV isolated from domestic dogs in the Brazilian Center-West region. Sequence alignment and phylogenetic analyses based on deduced amino acid and nucleotide sequences showed that the isolated strain is characterized as the South America-I/Europe genotype. However, it segregates into a CDV subgenotype branch. Interestingly, both H and F proteins have a gain of a potential N-glycosylation sites compared to the Onderstepoort vaccine strain. Therefore, this study provides a reference to further understand the epidemic and molecular characteristics of the CDV in Brazil.
format	article
author	Vivaldo Gomes da Costa Marielena Vogel Saivish Priscila Gomes de Oliveira Abelardo Silva-Júnior Marcos Lázaro Moreli Ricardo Henrique Krüger
author_facet	Vivaldo Gomes da Costa Marielena Vogel Saivish Priscila Gomes de Oliveira Abelardo Silva-Júnior Marcos Lázaro Moreli Ricardo Henrique Krüger
author_sort	Vivaldo Gomes da Costa
title	First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil
title_short	First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil
title_full	First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil
title_fullStr	First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil
title_full_unstemmed	First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil
title_sort	first complete genome sequence and molecular characterization of canine morbillivirus isolated in central brazil
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b0961c1707184499a667769a98a4e4ca
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First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil

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