New Approaches to Microbiome-Based Therapies

ABSTRACT Over the last decade, our understanding of the composition and functions of the gut microbiota has greatly increased. To a large extent, this has been due to the development of high-throughput genomic analyses of microbial communities, which have identified the critical contributions of the...

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Autores principales:	Andrea C. Wong, Maayan Levy
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	gnotobiotics metabolites metagenomics microbiome microbiome-based therapies postbiotics Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b096209cbfcb48809b097e57ef319385
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spelling	oai:doaj.org-article:b096209cbfcb48809b097e57ef3193852021-12-02T18:44:39ZNew Approaches to Microbiome-Based Therapies10.1128/mSystems.00122-192379-5077https://doaj.org/article/b096209cbfcb48809b097e57ef3193852019-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00122-19https://doaj.org/toc/2379-5077ABSTRACT Over the last decade, our understanding of the composition and functions of the gut microbiota has greatly increased. To a large extent, this has been due to the development of high-throughput genomic analyses of microbial communities, which have identified the critical contributions of the microbiome to human health. Consequently, the intestinal microbiota has emerged as an attractive therapeutic target. The large majority of microbiota-targeted therapies aim at engineering the intestinal ecosystem by means of probiotics or prebiotics. Recently, a novel therapeutic approach has emerged which focuses on molecules that are secreted, modulated, or degraded by the microbiome and act directly on the host. Here, we discuss the advantages and challenges associated with the metabolite-based “postbiotic” approach, highlighting recent progress and the areas that need intensive attention and investigation over the next 5 years. The time is ripe for postbiotic therapies to be developed in the near future.Andrea C. WongMaayan LevyAmerican Society for Microbiologyarticlegnotobioticsmetabolitesmetagenomicsmicrobiomemicrobiome-based therapiespostbioticsMicrobiologyQR1-502ENmSystems, Vol 4, Iss 3 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	gnotobiotics metabolites metagenomics microbiome microbiome-based therapies postbiotics Microbiology QR1-502
spellingShingle	gnotobiotics metabolites metagenomics microbiome microbiome-based therapies postbiotics Microbiology QR1-502 Andrea C. Wong Maayan Levy New Approaches to Microbiome-Based Therapies
description	ABSTRACT Over the last decade, our understanding of the composition and functions of the gut microbiota has greatly increased. To a large extent, this has been due to the development of high-throughput genomic analyses of microbial communities, which have identified the critical contributions of the microbiome to human health. Consequently, the intestinal microbiota has emerged as an attractive therapeutic target. The large majority of microbiota-targeted therapies aim at engineering the intestinal ecosystem by means of probiotics or prebiotics. Recently, a novel therapeutic approach has emerged which focuses on molecules that are secreted, modulated, or degraded by the microbiome and act directly on the host. Here, we discuss the advantages and challenges associated with the metabolite-based “postbiotic” approach, highlighting recent progress and the areas that need intensive attention and investigation over the next 5 years. The time is ripe for postbiotic therapies to be developed in the near future.
format	article
author	Andrea C. Wong Maayan Levy
author_facet	Andrea C. Wong Maayan Levy
author_sort	Andrea C. Wong
title	New Approaches to Microbiome-Based Therapies
title_short	New Approaches to Microbiome-Based Therapies
title_full	New Approaches to Microbiome-Based Therapies
title_fullStr	New Approaches to Microbiome-Based Therapies
title_full_unstemmed	New Approaches to Microbiome-Based Therapies
title_sort	new approaches to microbiome-based therapies
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/b096209cbfcb48809b097e57ef319385
work_keys_str_mv	AT andreacwong newapproachestomicrobiomebasedtherapies AT maayanlevy newapproachestomicrobiomebasedtherapies
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New Approaches to Microbiome-Based Therapies

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