Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

Fasting induces hepatic autophagy to preserve energy homeostasis. Here the authors report that fasting induced fibroblast growth factor 21 signalling induces autophagy by activating lysine-specific demethylase 6B, leading to histone demethylation mediated activation of autophagy genes.

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Autores principales:	Sangwon Byun, Sunmi Seok, Young-Chae Kim, Yang Zhang, Peter Yau, Naoki Iwamori, H. Eric Xu, Jian Ma, Byron Kemper, Jongsook Kim Kemper
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b09622a6d2874953bf49b30f72ae88ef
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spelling	oai:doaj.org-article:b09622a6d2874953bf49b30f72ae88ef2021-12-02T15:37:14ZFasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase10.1038/s41467-020-14384-z2041-1723https://doaj.org/article/b09622a6d2874953bf49b30f72ae88ef2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14384-zhttps://doaj.org/toc/2041-1723Fasting induces hepatic autophagy to preserve energy homeostasis. Here the authors report that fasting induced fibroblast growth factor 21 signalling induces autophagy by activating lysine-specific demethylase 6B, leading to histone demethylation mediated activation of autophagy genes.Sangwon ByunSunmi SeokYoung-Chae KimYang ZhangPeter YauNaoki IwamoriH. Eric XuJian MaByron KemperJongsook Kim KemperNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sangwon Byun Sunmi Seok Young-Chae Kim Yang Zhang Peter Yau Naoki Iwamori H. Eric Xu Jian Ma Byron Kemper Jongsook Kim Kemper Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase
description	Fasting induces hepatic autophagy to preserve energy homeostasis. Here the authors report that fasting induced fibroblast growth factor 21 signalling induces autophagy by activating lysine-specific demethylase 6B, leading to histone demethylation mediated activation of autophagy genes.
format	article
author	Sangwon Byun Sunmi Seok Young-Chae Kim Yang Zhang Peter Yau Naoki Iwamori H. Eric Xu Jian Ma Byron Kemper Jongsook Kim Kemper
author_facet	Sangwon Byun Sunmi Seok Young-Chae Kim Yang Zhang Peter Yau Naoki Iwamori H. Eric Xu Jian Ma Byron Kemper Jongsook Kim Kemper
author_sort	Sangwon Byun
title	Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase
title_short	Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase
title_full	Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase
title_fullStr	Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase
title_full_unstemmed	Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase
title_sort	fasting-induced fgf21 signaling activates hepatic autophagy and lipid degradation via jmjd3 histone demethylase
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b09622a6d2874953bf49b30f72ae88ef
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Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

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