Recent Advances in Pharmacological Intervention of Osteoarthritis: A Biological Aspect

Osteoarthritis (OA) is a degenerative joint disease in the musculoskeletal system with a relatively high incidence and disability rate in the elderly. It is characterized by the degradation of articular cartilage, inflammation of the synovial membrane, and abnormal structure in the periarticular and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jinxia Deng, Zhixian Zong, Zhanpeng Su, Haicong Chen, Jianping Huang, Yanru Niu, Huan Zhong, Bo Wei
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	osteoarthritis DNA RNA exosomes platelet-rich plasma protein Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/b0988ae9a17848398b9950d4be0b511a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b0988ae9a17848398b9950d4be0b511a
record_format	dspace
spelling	oai:doaj.org-article:b0988ae9a17848398b9950d4be0b511a2021-11-30T12:29:15ZRecent Advances in Pharmacological Intervention of Osteoarthritis: A Biological Aspect1663-981210.3389/fphar.2021.772678https://doaj.org/article/b0988ae9a17848398b9950d4be0b511a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.772678/fullhttps://doaj.org/toc/1663-9812Osteoarthritis (OA) is a degenerative joint disease in the musculoskeletal system with a relatively high incidence and disability rate in the elderly. It is characterized by the degradation of articular cartilage, inflammation of the synovial membrane, and abnormal structure in the periarticular and subchondral bones. Although progress has been made in uncovering the molecular mechanism, the etiology of OA is still complicated and unclear. Nevertheless, there is no treatment method that can effectively prevent or reverse the deterioration of cartilage and bone structure. In recent years, in the field of pharmacology, research focus has shifted to disease prevention and early treatment rather than disease modification in OA. Biologic agents become more and more attractive as their direct or indirect intervention effects on the initiation or development of OA. In this review, we will discuss a wide spectrum of biologic agents ranging from DNA, noncoding RNA, exosome, platelet-rich plasma (PRP), to protein. We searched for key words such as OA, DNA, gene, RNA, exosome, PRP, protein, and so on. From the pharmacological aspect, stem cell therapy is a very special technique, which is not included in this review. The literatures ranging from January 2016 to August 2021 were included and summarized. In this review, we aim to help readers have a complete and precise understanding of the current pharmacological research progress in the intervention of OA from the biological aspect and provide an indication for the future translational studies.Jinxia DengZhixian ZongZhanpeng SuHaicong ChenJianping HuangJianping HuangYanru NiuHuan ZhongBo WeiFrontiers Media S.A.articleosteoarthritisDNARNAexosomesplatelet-rich plasmaproteinTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteoarthritis DNA RNA exosomes platelet-rich plasma protein Therapeutics. Pharmacology RM1-950
spellingShingle	osteoarthritis DNA RNA exosomes platelet-rich plasma protein Therapeutics. Pharmacology RM1-950 Jinxia Deng Zhixian Zong Zhanpeng Su Haicong Chen Jianping Huang Jianping Huang Yanru Niu Huan Zhong Bo Wei Recent Advances in Pharmacological Intervention of Osteoarthritis: A Biological Aspect
description	Osteoarthritis (OA) is a degenerative joint disease in the musculoskeletal system with a relatively high incidence and disability rate in the elderly. It is characterized by the degradation of articular cartilage, inflammation of the synovial membrane, and abnormal structure in the periarticular and subchondral bones. Although progress has been made in uncovering the molecular mechanism, the etiology of OA is still complicated and unclear. Nevertheless, there is no treatment method that can effectively prevent or reverse the deterioration of cartilage and bone structure. In recent years, in the field of pharmacology, research focus has shifted to disease prevention and early treatment rather than disease modification in OA. Biologic agents become more and more attractive as their direct or indirect intervention effects on the initiation or development of OA. In this review, we will discuss a wide spectrum of biologic agents ranging from DNA, noncoding RNA, exosome, platelet-rich plasma (PRP), to protein. We searched for key words such as OA, DNA, gene, RNA, exosome, PRP, protein, and so on. From the pharmacological aspect, stem cell therapy is a very special technique, which is not included in this review. The literatures ranging from January 2016 to August 2021 were included and summarized. In this review, we aim to help readers have a complete and precise understanding of the current pharmacological research progress in the intervention of OA from the biological aspect and provide an indication for the future translational studies.
format	article
author	Jinxia Deng Zhixian Zong Zhanpeng Su Haicong Chen Jianping Huang Jianping Huang Yanru Niu Huan Zhong Bo Wei
author_facet	Jinxia Deng Zhixian Zong Zhanpeng Su Haicong Chen Jianping Huang Jianping Huang Yanru Niu Huan Zhong Bo Wei
author_sort	Jinxia Deng
title	Recent Advances in Pharmacological Intervention of Osteoarthritis: A Biological Aspect
title_short	Recent Advances in Pharmacological Intervention of Osteoarthritis: A Biological Aspect
title_full	Recent Advances in Pharmacological Intervention of Osteoarthritis: A Biological Aspect
title_fullStr	Recent Advances in Pharmacological Intervention of Osteoarthritis: A Biological Aspect
title_full_unstemmed	Recent Advances in Pharmacological Intervention of Osteoarthritis: A Biological Aspect
title_sort	recent advances in pharmacological intervention of osteoarthritis: a biological aspect
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b0988ae9a17848398b9950d4be0b511a
work_keys_str_mv	AT jinxiadeng recentadvancesinpharmacologicalinterventionofosteoarthritisabiologicalaspect AT zhixianzong recentadvancesinpharmacologicalinterventionofosteoarthritisabiologicalaspect AT zhanpengsu recentadvancesinpharmacologicalinterventionofosteoarthritisabiologicalaspect AT haicongchen recentadvancesinpharmacologicalinterventionofosteoarthritisabiologicalaspect AT jianpinghuang recentadvancesinpharmacologicalinterventionofosteoarthritisabiologicalaspect AT jianpinghuang recentadvancesinpharmacologicalinterventionofosteoarthritisabiologicalaspect AT yanruniu recentadvancesinpharmacologicalinterventionofosteoarthritisabiologicalaspect AT huanzhong recentadvancesinpharmacologicalinterventionofosteoarthritisabiologicalaspect AT bowei recentadvancesinpharmacologicalinterventionofosteoarthritisabiologicalaspect
_version_	1718406644437614592

Recent Advances in Pharmacological Intervention of Osteoarthritis: A Biological Aspect

Ejemplares similares