Overexpression of miR-142-5p and miR-155 in gastric mucosa-associated lymphoid tissue (MALT) lymphoma resistant to Helicobacter pylori eradication.
microRNAs (miRNAs) are small non-coding RNAs that can function as endogenous silencers of target genes and play critical roles in human malignancies. To investigate the molecular pathogenesis of gastric mucosa-associated lymphoid tissue (MALT) lymphoma, the miRNA expression profile was analyzed. miR...
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2012
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oai:doaj.org-article:b098dc206a5f4032b0ec384bd0128d872021-11-18T08:07:20ZOverexpression of miR-142-5p and miR-155 in gastric mucosa-associated lymphoid tissue (MALT) lymphoma resistant to Helicobacter pylori eradication.1932-620310.1371/journal.pone.0047396https://doaj.org/article/b098dc206a5f4032b0ec384bd0128d872012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23209550/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203microRNAs (miRNAs) are small non-coding RNAs that can function as endogenous silencers of target genes and play critical roles in human malignancies. To investigate the molecular pathogenesis of gastric mucosa-associated lymphoid tissue (MALT) lymphoma, the miRNA expression profile was analyzed. miRNA microarray analysis with tissue specimens from gastric MALT lymphomas and surrounding non-tumor mucosae revealed that a hematopoietic-specific miRNA miR-142 and an oncogenic miRNA miR-155 were overexpressed in MALT lymphoma lesions. The expression levels of miR-142-5p and miR-155 were significantly increased in MALT lymphomas which do not respond to Helicobacter pylori (H. pylori) eradication. The expression levels of miR-142-5p and miR-155 were associated with the clinical courses of gastric MALT lymphoma cases. Overexpression of miR-142-5p and miR-155 was also observed in Helicobacter heilmannii-infected C57BL/6 mice, an animal model of gastric MALT lymphoma. In addition, miR-142-5p and miR-155 suppress the proapoptotic gene TP53INP1 as their target. The results of this study indicate that overexpression of miR-142-5p and miR-155 plays a critical role in the pathogenesis of gastric MALT lymphoma. These miRNAs might have potential application as therapeutic targets and novel biomarkers for gastric MALT lymphoma.Yoshimasa SaitoHidekazu SuzukiHitoshi TsugawaHiroyuki ImaedaJuntaro MatsuzakiKenro HirataNaoki HosoeMasahiko NakamuraMakio MukaiHidetsugu SaitoToshifumi HibiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e47396 (2012) |
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Medicine R Science Q Yoshimasa Saito Hidekazu Suzuki Hitoshi Tsugawa Hiroyuki Imaeda Juntaro Matsuzaki Kenro Hirata Naoki Hosoe Masahiko Nakamura Makio Mukai Hidetsugu Saito Toshifumi Hibi Overexpression of miR-142-5p and miR-155 in gastric mucosa-associated lymphoid tissue (MALT) lymphoma resistant to Helicobacter pylori eradication. |
| description |
microRNAs (miRNAs) are small non-coding RNAs that can function as endogenous silencers of target genes and play critical roles in human malignancies. To investigate the molecular pathogenesis of gastric mucosa-associated lymphoid tissue (MALT) lymphoma, the miRNA expression profile was analyzed. miRNA microarray analysis with tissue specimens from gastric MALT lymphomas and surrounding non-tumor mucosae revealed that a hematopoietic-specific miRNA miR-142 and an oncogenic miRNA miR-155 were overexpressed in MALT lymphoma lesions. The expression levels of miR-142-5p and miR-155 were significantly increased in MALT lymphomas which do not respond to Helicobacter pylori (H. pylori) eradication. The expression levels of miR-142-5p and miR-155 were associated with the clinical courses of gastric MALT lymphoma cases. Overexpression of miR-142-5p and miR-155 was also observed in Helicobacter heilmannii-infected C57BL/6 mice, an animal model of gastric MALT lymphoma. In addition, miR-142-5p and miR-155 suppress the proapoptotic gene TP53INP1 as their target. The results of this study indicate that overexpression of miR-142-5p and miR-155 plays a critical role in the pathogenesis of gastric MALT lymphoma. These miRNAs might have potential application as therapeutic targets and novel biomarkers for gastric MALT lymphoma. |
| format |
article |
| author |
Yoshimasa Saito Hidekazu Suzuki Hitoshi Tsugawa Hiroyuki Imaeda Juntaro Matsuzaki Kenro Hirata Naoki Hosoe Masahiko Nakamura Makio Mukai Hidetsugu Saito Toshifumi Hibi |
| author_facet |
Yoshimasa Saito Hidekazu Suzuki Hitoshi Tsugawa Hiroyuki Imaeda Juntaro Matsuzaki Kenro Hirata Naoki Hosoe Masahiko Nakamura Makio Mukai Hidetsugu Saito Toshifumi Hibi |
| author_sort |
Yoshimasa Saito |
| title |
Overexpression of miR-142-5p and miR-155 in gastric mucosa-associated lymphoid tissue (MALT) lymphoma resistant to Helicobacter pylori eradication. |
| title_short |
Overexpression of miR-142-5p and miR-155 in gastric mucosa-associated lymphoid tissue (MALT) lymphoma resistant to Helicobacter pylori eradication. |
| title_full |
Overexpression of miR-142-5p and miR-155 in gastric mucosa-associated lymphoid tissue (MALT) lymphoma resistant to Helicobacter pylori eradication. |
| title_fullStr |
Overexpression of miR-142-5p and miR-155 in gastric mucosa-associated lymphoid tissue (MALT) lymphoma resistant to Helicobacter pylori eradication. |
| title_full_unstemmed |
Overexpression of miR-142-5p and miR-155 in gastric mucosa-associated lymphoid tissue (MALT) lymphoma resistant to Helicobacter pylori eradication. |
| title_sort |
overexpression of mir-142-5p and mir-155 in gastric mucosa-associated lymphoid tissue (malt) lymphoma resistant to helicobacter pylori eradication. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/b098dc206a5f4032b0ec384bd0128d87 |
| work_keys_str_mv |
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