BLOOD SERUM CYTOKINE PROFILE IN PATIENTS WITH СRONIC EXTENDED DERMATOSES AND ENDOGENOUS INTOXICATION SYNDROME

Abstract. The article presents data about blood serum cytokine profile in patients with chronic widespread dermatoses, associated with increase in blood markers of endogenous intoxication (EI) syndrome, i.e., lowand medium-molecular mass substances (LMWS). A close interrelation has been revealed bet...

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Autores principales:	T. V. Kopytova, N. A. Dobrotyna, L. N. Himkina, N. A. Shelchkova, G. A. Panteleeva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	chronic dermatoses interleukins endogenous intoxication Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b09afa6b5f164dada2d54cfeac08ca64
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spelling	oai:doaj.org-article:b09afa6b5f164dada2d54cfeac08ca642021-11-18T08:03:42ZBLOOD SERUM CYTOKINE PROFILE IN PATIENTS WITH СRONIC EXTENDED DERMATOSES AND ENDOGENOUS INTOXICATION SYNDROME1563-06252313-741X10.15789/1563-0625-2011-2-3-205-210https://doaj.org/article/b09afa6b5f164dada2d54cfeac08ca642014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/489https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The article presents data about blood serum cytokine profile in patients with chronic widespread dermatoses, associated with increase in blood markers of endogenous intoxication (EI) syndrome, i.e., lowand medium-molecular mass substances (LMWS). A close interrelation has been revealed between EI levels, and cytokine profiles. In the patients with high amounts of blood LMWS, increased levels of anti-inflammatory IL have been shown. Correlation analysis of clinical and laboratory parameters has demonstrated a leading role of EI in pathogenetic mechanisms of chronic extended dermatoses, and brings about altered regulation of metabolic processes. A severe clinical course of dermatoses (i.e., therapy resistance) was associated with a considerable decrease in blood IL-8 and IL-10 levels, along with high IgE and LMWS amounts. (Med. Immunol., 2011, vol. 13, N 2-3, pp 205-210)T. V. KopytovaN. A. DobrotynaL. N. HimkinaN. A. ShelchkovaG. A. PanteleevaSPb RAACIarticlechronic dermatosesinterleukinsendogenous intoxicationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 2-3, Pp 205-210 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic dermatoses interleukins endogenous intoxication Immunologic diseases. Allergy RC581-607
spellingShingle	chronic dermatoses interleukins endogenous intoxication Immunologic diseases. Allergy RC581-607 T. V. Kopytova N. A. Dobrotyna L. N. Himkina N. A. Shelchkova G. A. Panteleeva BLOOD SERUM CYTOKINE PROFILE IN PATIENTS WITH СRONIC EXTENDED DERMATOSES AND ENDOGENOUS INTOXICATION SYNDROME
description	Abstract. The article presents data about blood serum cytokine profile in patients with chronic widespread dermatoses, associated with increase in blood markers of endogenous intoxication (EI) syndrome, i.e., lowand medium-molecular mass substances (LMWS). A close interrelation has been revealed between EI levels, and cytokine profiles. In the patients with high amounts of blood LMWS, increased levels of anti-inflammatory IL have been shown. Correlation analysis of clinical and laboratory parameters has demonstrated a leading role of EI in pathogenetic mechanisms of chronic extended dermatoses, and brings about altered regulation of metabolic processes. A severe clinical course of dermatoses (i.e., therapy resistance) was associated with a considerable decrease in blood IL-8 and IL-10 levels, along with high IgE and LMWS amounts. (Med. Immunol., 2011, vol. 13, N 2-3, pp 205-210)
format	article
author	T. V. Kopytova N. A. Dobrotyna L. N. Himkina N. A. Shelchkova G. A. Panteleeva
author_facet	T. V. Kopytova N. A. Dobrotyna L. N. Himkina N. A. Shelchkova G. A. Panteleeva
author_sort	T. V. Kopytova
title	BLOOD SERUM CYTOKINE PROFILE IN PATIENTS WITH СRONIC EXTENDED DERMATOSES AND ENDOGENOUS INTOXICATION SYNDROME
title_short	BLOOD SERUM CYTOKINE PROFILE IN PATIENTS WITH СRONIC EXTENDED DERMATOSES AND ENDOGENOUS INTOXICATION SYNDROME
title_full	BLOOD SERUM CYTOKINE PROFILE IN PATIENTS WITH СRONIC EXTENDED DERMATOSES AND ENDOGENOUS INTOXICATION SYNDROME
title_fullStr	BLOOD SERUM CYTOKINE PROFILE IN PATIENTS WITH СRONIC EXTENDED DERMATOSES AND ENDOGENOUS INTOXICATION SYNDROME
title_full_unstemmed	BLOOD SERUM CYTOKINE PROFILE IN PATIENTS WITH СRONIC EXTENDED DERMATOSES AND ENDOGENOUS INTOXICATION SYNDROME
title_sort	blood serum cytokine profile in patients with сronic extended dermatoses and endogenous intoxication syndrome
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/b09afa6b5f164dada2d54cfeac08ca64
work_keys_str_mv	AT tvkopytova bloodserumcytokineprofileinpatientswithsronicextendeddermatosesandendogenousintoxicationsyndrome AT nadobrotyna bloodserumcytokineprofileinpatientswithsronicextendeddermatosesandendogenousintoxicationsyndrome AT lnhimkina bloodserumcytokineprofileinpatientswithsronicextendeddermatosesandendogenousintoxicationsyndrome AT nashelchkova bloodserumcytokineprofileinpatientswithsronicextendeddermatosesandendogenousintoxicationsyndrome AT gapanteleeva bloodserumcytokineprofileinpatientswithsronicextendeddermatosesandendogenousintoxicationsyndrome
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BLOOD SERUM CYTOKINE PROFILE IN PATIENTS WITH СRONIC EXTENDED DERMATOSES AND ENDOGENOUS INTOXICATION SYNDROME

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