Myocardial changes on 3T cardiovascular magnetic resonance imaging in response to haemodialysis with fluid removal

Abstract Background Mapping of left ventricular (LV) native T1 is a promising non-invasive, non-contrast imaging biomarker. Native myocardial T1 times are prolonged in patients requiring dialysis, but there are concerns that the dialysis process and fluctuating fluid status may confound results in t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alastair J. Rankin, Kenneth Mangion, Jennifer S. Lees, Elaine Rutherford, Keith A. Gillis, Elbert Edy, Laura Dymock, Thomas A. Treibel, Aleksandra Radjenovic, Rajan K. Patel, Colin Berry, Giles Roditi, Patrick B. Mark
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	End-stage kidney disease Haemodialysis Cardiovascular Magnetic resonance imaging Left ventricular hypertrophy Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/b09bc2336d394966b648a3328f235fff
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b09bc2336d394966b648a3328f235fff
record_format	dspace
spelling	oai:doaj.org-article:b09bc2336d394966b648a3328f235fff2021-11-14T12:12:50ZMyocardial changes on 3T cardiovascular magnetic resonance imaging in response to haemodialysis with fluid removal10.1186/s12968-021-00822-41532-429Xhttps://doaj.org/article/b09bc2336d394966b648a3328f235fff2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12968-021-00822-4https://doaj.org/toc/1532-429XAbstract Background Mapping of left ventricular (LV) native T1 is a promising non-invasive, non-contrast imaging biomarker. Native myocardial T1 times are prolonged in patients requiring dialysis, but there are concerns that the dialysis process and fluctuating fluid status may confound results in this population. We aimed to assess the changes in cardiac parameters on 3T cardiovascular magnetic resonance (CMR) before and after haemodialysis, with a specific focus on native T1 mapping. Methods This is a single centre, prospective observational study in which maintenance haemodialysis patients underwent CMR before and after dialysis (both scans within 24 h). Weight measurement, bio-impedance body composition monitoring, haemodialysis details and fluid intake were recorded. CMR protocol included cine imaging and mapping native T1 and T2. Results Twenty-six participants (16 male, 65 ± 9 years) were included in the analysis. The median net ultrafiltration volume on dialysis was 2.3 L (IQR 1.8, 2.5), resulting in a median weight reduction at post-dialysis scan of 1.35 kg (IQR 1.0, 1.9), with a median reduction in over-hydration (as measured by bioimpedance) of 0.75 L (IQR 0.5, 1.4). Significant reductions were observed in LV end-diastolic volume (− 25 ml, p = 0.002), LV stroke volume (− 13 ml, p = 0.007), global T1 (21 ms, p = 0.02), global T2 (− 1.2 ms, p = 0.02) following dialysis. There was no change in LV mass (p = 0.35), LV ejection fraction (p = 0.13) or global longitudinal strain (p = 0.22). On linear regression there was no association between baseline over-hydration (as defined by bioimpedance) and global native T1 or global T2, nor was there an association between the change in over-hydration and the change in these parameters. Conclusions Acute changes in cardiac volumes and myocardial native T1 are detectable on 3T CMR following haemodialysis with fluid removal. The reduction in global T1 suggests that the abnormal native T1 observed in patients on haemodialysis is not entirely due to myocardial fibrosis.Alastair J. RankinKenneth MangionJennifer S. LeesElaine RutherfordKeith A. GillisElbert EdyLaura DymockThomas A. TreibelAleksandra RadjenovicRajan K. PatelColin BerryGiles RoditiPatrick B. MarkBMCarticleEnd-stage kidney diseaseHaemodialysisCardiovascularMagnetic resonance imagingLeft ventricular hypertrophyDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of Cardiovascular Magnetic Resonance, Vol 23, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	End-stage kidney disease Haemodialysis Cardiovascular Magnetic resonance imaging Left ventricular hypertrophy Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	End-stage kidney disease Haemodialysis Cardiovascular Magnetic resonance imaging Left ventricular hypertrophy Diseases of the circulatory (Cardiovascular) system RC666-701 Alastair J. Rankin Kenneth Mangion Jennifer S. Lees Elaine Rutherford Keith A. Gillis Elbert Edy Laura Dymock Thomas A. Treibel Aleksandra Radjenovic Rajan K. Patel Colin Berry Giles Roditi Patrick B. Mark Myocardial changes on 3T cardiovascular magnetic resonance imaging in response to haemodialysis with fluid removal
description	Abstract Background Mapping of left ventricular (LV) native T1 is a promising non-invasive, non-contrast imaging biomarker. Native myocardial T1 times are prolonged in patients requiring dialysis, but there are concerns that the dialysis process and fluctuating fluid status may confound results in this population. We aimed to assess the changes in cardiac parameters on 3T cardiovascular magnetic resonance (CMR) before and after haemodialysis, with a specific focus on native T1 mapping. Methods This is a single centre, prospective observational study in which maintenance haemodialysis patients underwent CMR before and after dialysis (both scans within 24 h). Weight measurement, bio-impedance body composition monitoring, haemodialysis details and fluid intake were recorded. CMR protocol included cine imaging and mapping native T1 and T2. Results Twenty-six participants (16 male, 65 ± 9 years) were included in the analysis. The median net ultrafiltration volume on dialysis was 2.3 L (IQR 1.8, 2.5), resulting in a median weight reduction at post-dialysis scan of 1.35 kg (IQR 1.0, 1.9), with a median reduction in over-hydration (as measured by bioimpedance) of 0.75 L (IQR 0.5, 1.4). Significant reductions were observed in LV end-diastolic volume (− 25 ml, p = 0.002), LV stroke volume (− 13 ml, p = 0.007), global T1 (21 ms, p = 0.02), global T2 (− 1.2 ms, p = 0.02) following dialysis. There was no change in LV mass (p = 0.35), LV ejection fraction (p = 0.13) or global longitudinal strain (p = 0.22). On linear regression there was no association between baseline over-hydration (as defined by bioimpedance) and global native T1 or global T2, nor was there an association between the change in over-hydration and the change in these parameters. Conclusions Acute changes in cardiac volumes and myocardial native T1 are detectable on 3T CMR following haemodialysis with fluid removal. The reduction in global T1 suggests that the abnormal native T1 observed in patients on haemodialysis is not entirely due to myocardial fibrosis.
format	article
author	Alastair J. Rankin Kenneth Mangion Jennifer S. Lees Elaine Rutherford Keith A. Gillis Elbert Edy Laura Dymock Thomas A. Treibel Aleksandra Radjenovic Rajan K. Patel Colin Berry Giles Roditi Patrick B. Mark
author_facet	Alastair J. Rankin Kenneth Mangion Jennifer S. Lees Elaine Rutherford Keith A. Gillis Elbert Edy Laura Dymock Thomas A. Treibel Aleksandra Radjenovic Rajan K. Patel Colin Berry Giles Roditi Patrick B. Mark
author_sort	Alastair J. Rankin
title	Myocardial changes on 3T cardiovascular magnetic resonance imaging in response to haemodialysis with fluid removal
title_short	Myocardial changes on 3T cardiovascular magnetic resonance imaging in response to haemodialysis with fluid removal
title_full	Myocardial changes on 3T cardiovascular magnetic resonance imaging in response to haemodialysis with fluid removal
title_fullStr	Myocardial changes on 3T cardiovascular magnetic resonance imaging in response to haemodialysis with fluid removal
title_full_unstemmed	Myocardial changes on 3T cardiovascular magnetic resonance imaging in response to haemodialysis with fluid removal
title_sort	myocardial changes on 3t cardiovascular magnetic resonance imaging in response to haemodialysis with fluid removal
publisher	BMC
publishDate	2021
url	https://doaj.org/article/b09bc2336d394966b648a3328f235fff
work_keys_str_mv	AT alastairjrankin myocardialchangeson3tcardiovascularmagneticresonanceimaginginresponsetohaemodialysiswithfluidremoval AT kennethmangion myocardialchangeson3tcardiovascularmagneticresonanceimaginginresponsetohaemodialysiswithfluidremoval AT jenniferslees myocardialchangeson3tcardiovascularmagneticresonanceimaginginresponsetohaemodialysiswithfluidremoval AT elainerutherford myocardialchangeson3tcardiovascularmagneticresonanceimaginginresponsetohaemodialysiswithfluidremoval AT keithagillis myocardialchangeson3tcardiovascularmagneticresonanceimaginginresponsetohaemodialysiswithfluidremoval AT elbertedy myocardialchangeson3tcardiovascularmagneticresonanceimaginginresponsetohaemodialysiswithfluidremoval AT lauradymock myocardialchangeson3tcardiovascularmagneticresonanceimaginginresponsetohaemodialysiswithfluidremoval AT thomasatreibel myocardialchangeson3tcardiovascularmagneticresonanceimaginginresponsetohaemodialysiswithfluidremoval AT aleksandraradjenovic myocardialchangeson3tcardiovascularmagneticresonanceimaginginresponsetohaemodialysiswithfluidremoval AT rajankpatel myocardialchangeson3tcardiovascularmagneticresonanceimaginginresponsetohaemodialysiswithfluidremoval AT colinberry myocardialchangeson3tcardiovascularmagneticresonanceimaginginresponsetohaemodialysiswithfluidremoval AT gilesroditi myocardialchangeson3tcardiovascularmagneticresonanceimaginginresponsetohaemodialysiswithfluidremoval AT patrickbmark myocardialchangeson3tcardiovascularmagneticresonanceimaginginresponsetohaemodialysiswithfluidremoval
_version_	1718429367323852800

Myocardial changes on 3T cardiovascular magnetic resonance imaging in response to haemodialysis with fluid removal

Ejemplares similares