Enantioselective access to chiral aliphatic amines and alcohols via Ni-catalyzed hydroalkylations

Chiral aliphatic amine and alcohol derivatives are difficult to access due to the challenge to differentiate between spatially and electronically similar alkyl groups. Here the authors show a nickel-catalyzed enantioselective hydroalkylation of acyl enamines and enol esters with alkyl halides to aff...

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Autores principales:	Shan Wang, Jian-Xin Zhang, Tian-Yi Zhang, Huan Meng, Bi-Hong Chen, Wei Shu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b09c196bb05141289813ae569bf9f442
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spelling	oai:doaj.org-article:b09c196bb05141289813ae569bf9f4422021-12-02T16:50:35ZEnantioselective access to chiral aliphatic amines and alcohols via Ni-catalyzed hydroalkylations10.1038/s41467-021-22983-72041-1723https://doaj.org/article/b09c196bb05141289813ae569bf9f4422021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22983-7https://doaj.org/toc/2041-1723Chiral aliphatic amine and alcohol derivatives are difficult to access due to the challenge to differentiate between spatially and electronically similar alkyl groups. Here the authors show a nickel-catalyzed enantioselective hydroalkylation of acyl enamines and enol esters with alkyl halides to afford enantioenriched α-branched aliphatic acyl amines and esters in good yields with excellent enantioselectivity.Shan WangJian-Xin ZhangTian-Yi ZhangHuan MengBi-Hong ChenWei ShuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shan Wang Jian-Xin Zhang Tian-Yi Zhang Huan Meng Bi-Hong Chen Wei Shu Enantioselective access to chiral aliphatic amines and alcohols via Ni-catalyzed hydroalkylations
description	Chiral aliphatic amine and alcohol derivatives are difficult to access due to the challenge to differentiate between spatially and electronically similar alkyl groups. Here the authors show a nickel-catalyzed enantioselective hydroalkylation of acyl enamines and enol esters with alkyl halides to afford enantioenriched α-branched aliphatic acyl amines and esters in good yields with excellent enantioselectivity.
format	article
author	Shan Wang Jian-Xin Zhang Tian-Yi Zhang Huan Meng Bi-Hong Chen Wei Shu
author_facet	Shan Wang Jian-Xin Zhang Tian-Yi Zhang Huan Meng Bi-Hong Chen Wei Shu
author_sort	Shan Wang
title	Enantioselective access to chiral aliphatic amines and alcohols via Ni-catalyzed hydroalkylations
title_short	Enantioselective access to chiral aliphatic amines and alcohols via Ni-catalyzed hydroalkylations
title_full	Enantioselective access to chiral aliphatic amines and alcohols via Ni-catalyzed hydroalkylations
title_fullStr	Enantioselective access to chiral aliphatic amines and alcohols via Ni-catalyzed hydroalkylations
title_full_unstemmed	Enantioselective access to chiral aliphatic amines and alcohols via Ni-catalyzed hydroalkylations
title_sort	enantioselective access to chiral aliphatic amines and alcohols via ni-catalyzed hydroalkylations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b09c196bb05141289813ae569bf9f442
work_keys_str_mv	AT shanwang enantioselectiveaccesstochiralaliphaticaminesandalcoholsvianicatalyzedhydroalkylations AT jianxinzhang enantioselectiveaccesstochiralaliphaticaminesandalcoholsvianicatalyzedhydroalkylations AT tianyizhang enantioselectiveaccesstochiralaliphaticaminesandalcoholsvianicatalyzedhydroalkylations AT huanmeng enantioselectiveaccesstochiralaliphaticaminesandalcoholsvianicatalyzedhydroalkylations AT bihongchen enantioselectiveaccesstochiralaliphaticaminesandalcoholsvianicatalyzedhydroalkylations AT weishu enantioselectiveaccesstochiralaliphaticaminesandalcoholsvianicatalyzedhydroalkylations
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Enantioselective access to chiral aliphatic amines and alcohols via Ni-catalyzed hydroalkylations

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