Lipopolysaccharide induces inflammatory hyperalgesia triggering a TLR4/MyD88-dependent cytokine cascade in the mice paw.

Lipopolysaccharide induces inflammatory hyperalgesia triggering a TLR4/MyD88-dependent cytokine cascade in the mice paw.

Inflammatory pain can be triggered by different stimuli, such as trauma, radiation, antigen and infection. In a model of inflammatory pain caused by infection, injection in the mice paw of lipopolysaccharide (LPS), a Toll-like receptor 4 (TLR4) agonist, produces mechanical hyperalgesia. We identify...

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Bibliographic Details
Main Authors: Igor L Calil, Ana C Zarpelon, Ana T G Guerrero, Jose C Alves-Filho, Sergio H Ferreira, Fernando Q Cunha, Thiago M Cunha, Waldiceu A Verri
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/b09c2bc6c1ea48069bb39d41ac3d1b87
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