Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer
Reliable luminal estrogen receptor (ERα+) breast cancer models are limited. Here, the authors use patient derived breast epithelial and breast cancer explant cultures grown in several extracellular matrix scaffolds and show that ERα expression is regulated by matrix stiffness via stress-mediated p38...
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Nature Portfolio
2021
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oai:doaj.org-article:b09c6053c2ba40338196b223c95342472021-12-05T12:21:58ZCompressive stress-mediated p38 activation required for ERα + phenotype in breast cancer10.1038/s41467-021-27220-92041-1723https://doaj.org/article/b09c6053c2ba40338196b223c95342472021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27220-9https://doaj.org/toc/2041-1723Reliable luminal estrogen receptor (ERα+) breast cancer models are limited. Here, the authors use patient derived breast epithelial and breast cancer explant cultures grown in several extracellular matrix scaffolds and show that ERα expression is regulated by matrix stiffness via stress-mediated p38 activation and H3K27me3-mediated epigenetic regulation.Pauliina M. MunneLahja MartikainenIiris RätyKia BertulaNonappaJanika RuuskaHanna Ala-HongistoAino PeuraBabette HollmannLilya EuroKerim YavuzLinda PatrikainenMaria SalmelaJuho PokkiMikko KiventoJuho VäänänenTomi SuomiLiina NevalaitaMinna MutkaPanu KovanenMarjut LeideniusTuomo MeretojaKatja HukkinenOuti MonniJeroen PouwelsBiswajyoti SahuJohanna MattsonHeikki JoensuuPäivi HeikkiläLaura L. EloCiara MetcalfeMelissa R. JunttilaOlli IkkalaJuha KlefströmNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Pauliina M. Munne Lahja Martikainen Iiris Räty Kia Bertula Nonappa Janika Ruuska Hanna Ala-Hongisto Aino Peura Babette Hollmann Lilya Euro Kerim Yavuz Linda Patrikainen Maria Salmela Juho Pokki Mikko Kivento Juho Väänänen Tomi Suomi Liina Nevalaita Minna Mutka Panu Kovanen Marjut Leidenius Tuomo Meretoja Katja Hukkinen Outi Monni Jeroen Pouwels Biswajyoti Sahu Johanna Mattson Heikki Joensuu Päivi Heikkilä Laura L. Elo Ciara Metcalfe Melissa R. Junttila Olli Ikkala Juha Klefström Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer |
| description |
Reliable luminal estrogen receptor (ERα+) breast cancer models are limited. Here, the authors use patient derived breast epithelial and breast cancer explant cultures grown in several extracellular matrix scaffolds and show that ERα expression is regulated by matrix stiffness via stress-mediated p38 activation and H3K27me3-mediated epigenetic regulation. |
| format |
article |
| author |
Pauliina M. Munne Lahja Martikainen Iiris Räty Kia Bertula Nonappa Janika Ruuska Hanna Ala-Hongisto Aino Peura Babette Hollmann Lilya Euro Kerim Yavuz Linda Patrikainen Maria Salmela Juho Pokki Mikko Kivento Juho Väänänen Tomi Suomi Liina Nevalaita Minna Mutka Panu Kovanen Marjut Leidenius Tuomo Meretoja Katja Hukkinen Outi Monni Jeroen Pouwels Biswajyoti Sahu Johanna Mattson Heikki Joensuu Päivi Heikkilä Laura L. Elo Ciara Metcalfe Melissa R. Junttila Olli Ikkala Juha Klefström |
| author_facet |
Pauliina M. Munne Lahja Martikainen Iiris Räty Kia Bertula Nonappa Janika Ruuska Hanna Ala-Hongisto Aino Peura Babette Hollmann Lilya Euro Kerim Yavuz Linda Patrikainen Maria Salmela Juho Pokki Mikko Kivento Juho Väänänen Tomi Suomi Liina Nevalaita Minna Mutka Panu Kovanen Marjut Leidenius Tuomo Meretoja Katja Hukkinen Outi Monni Jeroen Pouwels Biswajyoti Sahu Johanna Mattson Heikki Joensuu Päivi Heikkilä Laura L. Elo Ciara Metcalfe Melissa R. Junttila Olli Ikkala Juha Klefström |
| author_sort |
Pauliina M. Munne |
| title |
Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer |
| title_short |
Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer |
| title_full |
Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer |
| title_fullStr |
Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer |
| title_full_unstemmed |
Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer |
| title_sort |
compressive stress-mediated p38 activation required for erα + phenotype in breast cancer |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/b09c6053c2ba40338196b223c9534247 |
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