Probiotics and Vitamin D/Vitamin D Receptor Pathway Interaction: Potential Therapeutic Implications in Inflammatory Bowel Disease

Inflammatory bowel diseases (IBD) are chronic conditions of unknown etiology and immunomediated pathogenesis. In the last years, the comprehension of the complex mechanisms involved in the intestinal mucosal homeostasis, and the analysis of the alterations potentially leading to inflammatory patholo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cristiano Pagnini, Maria Carla Di Paolo, Maria Giovanna Graziani, Gianfranco Delle Fave
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	inflammatory bowel disease probiotics vitamin D vitamin D receptor homoestasis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/b09ef489d04146bb9007a451069caa53
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b09ef489d04146bb9007a451069caa53
record_format	dspace
spelling	oai:doaj.org-article:b09ef489d04146bb9007a451069caa532021-12-01T02:54:26ZProbiotics and Vitamin D/Vitamin D Receptor Pathway Interaction: Potential Therapeutic Implications in Inflammatory Bowel Disease1663-981210.3389/fphar.2021.747856https://doaj.org/article/b09ef489d04146bb9007a451069caa532021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.747856/fullhttps://doaj.org/toc/1663-9812Inflammatory bowel diseases (IBD) are chronic conditions of unknown etiology and immunomediated pathogenesis. In the last years, the comprehension of the complex mechanisms involved in the intestinal mucosal homeostasis, and the analysis of the alterations potentially leading to inflammatory pathologic states, has consistently increased. Specifically, the extraordinary impulse in the field of research of the intestinal microbiome has opened the door to the investigation of possible novel approaches to the diagnosis, management and therapeutic applications in IBD. In line with that, administration of probiotic bacteria has been intensely evaluated, leading to much more exciting results in experimental models than in clinical practice. Considering the consistent heterogeneity of the available studies on probiotics, the increased knowledge of the properties of the single bacterial species would ideally lead to unravel potential mechanisms of action that may bring therapeutic applications in specific pathologic condition. Among the relevant molecular pathways for mucosal homeostasis maintenance, the vitamin D/vitamin D receptor (VDR) pathway has been intensely studied in the very last years. In fact, besides osteometabolic functions, the vitamin D exerts important homeostatic effects in the organism at multiple levels, such as immunomodulation, inflammation control, and microbiota regulation, which are likely to play a relevant role in intestinal mucosa protection. In the present review, recent findings about probiotic applications in IBD and mechanisms of action linking vitamin D/VDR pathway to IBD are reported. Available evidence for probiotic effect on vitamin D/VDR are reviewed and potential future application in IBD patients are discussed. At present, many aspects of IBD pathogenesis are still obscure, and current therapeutic options for IBD treatment are at best suboptimal. The increasing comprehension of the different pathways involved in IBD pathogenesis will lead to novel findings ideally leading to potential clinical applications. Microbiota manipulation and vitamin/VDR pathway appear a promising field for future research and therapeutic developments.Cristiano PagniniMaria Carla Di PaoloMaria Giovanna GrazianiGianfranco Delle FaveGianfranco Delle FaveFrontiers Media S.A.articleinflammatory bowel diseaseprobioticsvitamin Dvitamin D receptorhomoestasisTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammatory bowel disease probiotics vitamin D vitamin D receptor homoestasis Therapeutics. Pharmacology RM1-950
spellingShingle	inflammatory bowel disease probiotics vitamin D vitamin D receptor homoestasis Therapeutics. Pharmacology RM1-950 Cristiano Pagnini Maria Carla Di Paolo Maria Giovanna Graziani Gianfranco Delle Fave Gianfranco Delle Fave Probiotics and Vitamin D/Vitamin D Receptor Pathway Interaction: Potential Therapeutic Implications in Inflammatory Bowel Disease
description	Inflammatory bowel diseases (IBD) are chronic conditions of unknown etiology and immunomediated pathogenesis. In the last years, the comprehension of the complex mechanisms involved in the intestinal mucosal homeostasis, and the analysis of the alterations potentially leading to inflammatory pathologic states, has consistently increased. Specifically, the extraordinary impulse in the field of research of the intestinal microbiome has opened the door to the investigation of possible novel approaches to the diagnosis, management and therapeutic applications in IBD. In line with that, administration of probiotic bacteria has been intensely evaluated, leading to much more exciting results in experimental models than in clinical practice. Considering the consistent heterogeneity of the available studies on probiotics, the increased knowledge of the properties of the single bacterial species would ideally lead to unravel potential mechanisms of action that may bring therapeutic applications in specific pathologic condition. Among the relevant molecular pathways for mucosal homeostasis maintenance, the vitamin D/vitamin D receptor (VDR) pathway has been intensely studied in the very last years. In fact, besides osteometabolic functions, the vitamin D exerts important homeostatic effects in the organism at multiple levels, such as immunomodulation, inflammation control, and microbiota regulation, which are likely to play a relevant role in intestinal mucosa protection. In the present review, recent findings about probiotic applications in IBD and mechanisms of action linking vitamin D/VDR pathway to IBD are reported. Available evidence for probiotic effect on vitamin D/VDR are reviewed and potential future application in IBD patients are discussed. At present, many aspects of IBD pathogenesis are still obscure, and current therapeutic options for IBD treatment are at best suboptimal. The increasing comprehension of the different pathways involved in IBD pathogenesis will lead to novel findings ideally leading to potential clinical applications. Microbiota manipulation and vitamin/VDR pathway appear a promising field for future research and therapeutic developments.
format	article
author	Cristiano Pagnini Maria Carla Di Paolo Maria Giovanna Graziani Gianfranco Delle Fave Gianfranco Delle Fave
author_facet	Cristiano Pagnini Maria Carla Di Paolo Maria Giovanna Graziani Gianfranco Delle Fave Gianfranco Delle Fave
author_sort	Cristiano Pagnini
title	Probiotics and Vitamin D/Vitamin D Receptor Pathway Interaction: Potential Therapeutic Implications in Inflammatory Bowel Disease
title_short	Probiotics and Vitamin D/Vitamin D Receptor Pathway Interaction: Potential Therapeutic Implications in Inflammatory Bowel Disease
title_full	Probiotics and Vitamin D/Vitamin D Receptor Pathway Interaction: Potential Therapeutic Implications in Inflammatory Bowel Disease
title_fullStr	Probiotics and Vitamin D/Vitamin D Receptor Pathway Interaction: Potential Therapeutic Implications in Inflammatory Bowel Disease
title_full_unstemmed	Probiotics and Vitamin D/Vitamin D Receptor Pathway Interaction: Potential Therapeutic Implications in Inflammatory Bowel Disease
title_sort	probiotics and vitamin d/vitamin d receptor pathway interaction: potential therapeutic implications in inflammatory bowel disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b09ef489d04146bb9007a451069caa53
work_keys_str_mv	AT cristianopagnini probioticsandvitamindvitamindreceptorpathwayinteractionpotentialtherapeuticimplicationsininflammatoryboweldisease AT mariacarladipaolo probioticsandvitamindvitamindreceptorpathwayinteractionpotentialtherapeuticimplicationsininflammatoryboweldisease AT mariagiovannagraziani probioticsandvitamindvitamindreceptorpathwayinteractionpotentialtherapeuticimplicationsininflammatoryboweldisease AT gianfrancodellefave probioticsandvitamindvitamindreceptorpathwayinteractionpotentialtherapeuticimplicationsininflammatoryboweldisease AT gianfrancodellefave probioticsandvitamindvitamindreceptorpathwayinteractionpotentialtherapeuticimplicationsininflammatoryboweldisease
_version_	1718405922202583040

Probiotics and Vitamin D/Vitamin D Receptor Pathway Interaction: Potential Therapeutic Implications in Inflammatory Bowel Disease

Ejemplares similares