Hospital Frailty Risk Score Is Independently Associated with Mortality and Encephalopathy in Hospitalized Patients with Hepatocellular Carcinoma

Frailty represents a state of vulnerability to multiple internal physiologic factors, as well as external pressures, and has been associated with clinical outcomes. We aim to understand the impact of frailty on patients admitted with hepatocellular carcinoma (HCC) by using the validated Hospital Fra...

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Autores principales:	Daryl Ramai, Khoi P. Dang-Ho, Anjali Kewalramani, Praneeth Bandaru, Rodolfo Sacco, Luca Giacomelli, Aashni Shah, Simonetta Papa, Francesca Cappellini, Fabio Perversi, Sara di Nunzio, Antonio Facciorusso
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hepatocellular carcinoma frailty outcomes Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b0a05939b6ef4cc290f15d76cba697dc
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spelling	oai:doaj.org-article:b0a05939b6ef4cc290f15d76cba697dc2021-11-25T16:50:53ZHospital Frailty Risk Score Is Independently Associated with Mortality and Encephalopathy in Hospitalized Patients with Hepatocellular Carcinoma10.3390/biomedicines91116932227-9059https://doaj.org/article/b0a05939b6ef4cc290f15d76cba697dc2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1693https://doaj.org/toc/2227-9059Frailty represents a state of vulnerability to multiple internal physiologic factors, as well as external pressures, and has been associated with clinical outcomes. We aim to understand the impact of frailty on patients admitted with hepatocellular carcinoma (HCC) by using the validated Hospital Frailty Risk Score, which is implemented in several hospitals worldwide. We conducted a nation-wide retrospective cohort study to determine the effect of frailty on the risk of in-patient mortality, hepatic encephalopathy, length of stay and cost. Frailty was associated with a 4.5-fold increased risk of mortality and a 2.3-fold increased risk of hepatic encephalopathy. Adjusted Cox regression showed that frailty was correlated with increased risk of in-patient mortality (hazard ratio: 2.3, 95% CI 1.9–2.8, <i>p</i> < 0.001). Frail HCC patients had longer hospital stay (median 5 days) vs. non-frail HCC patients (median 3 days). Additionally, frail patients had higher total costs of hospitalization ($40,875) compared with non-frail patients ($31,667). Frailty is an independent predictor of hepatic encephalopathy and in-patient mortality. Frailty is a surrogate marker of hospital length of stay and cost.Daryl RamaiKhoi P. Dang-HoAnjali KewalramaniPraneeth BandaruRodolfo SaccoLuca GiacomelliAashni ShahSimonetta PapaFrancesca CappelliniFabio PerversiSara di NunzioAntonio FacciorussoMDPI AGarticlehepatocellular carcinomafrailtyoutcomesBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1693, p 1693 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma frailty outcomes Biology (General) QH301-705.5
spellingShingle	hepatocellular carcinoma frailty outcomes Biology (General) QH301-705.5 Daryl Ramai Khoi P. Dang-Ho Anjali Kewalramani Praneeth Bandaru Rodolfo Sacco Luca Giacomelli Aashni Shah Simonetta Papa Francesca Cappellini Fabio Perversi Sara di Nunzio Antonio Facciorusso Hospital Frailty Risk Score Is Independently Associated with Mortality and Encephalopathy in Hospitalized Patients with Hepatocellular Carcinoma
description	Frailty represents a state of vulnerability to multiple internal physiologic factors, as well as external pressures, and has been associated with clinical outcomes. We aim to understand the impact of frailty on patients admitted with hepatocellular carcinoma (HCC) by using the validated Hospital Frailty Risk Score, which is implemented in several hospitals worldwide. We conducted a nation-wide retrospective cohort study to determine the effect of frailty on the risk of in-patient mortality, hepatic encephalopathy, length of stay and cost. Frailty was associated with a 4.5-fold increased risk of mortality and a 2.3-fold increased risk of hepatic encephalopathy. Adjusted Cox regression showed that frailty was correlated with increased risk of in-patient mortality (hazard ratio: 2.3, 95% CI 1.9–2.8, <i>p</i> < 0.001). Frail HCC patients had longer hospital stay (median 5 days) vs. non-frail HCC patients (median 3 days). Additionally, frail patients had higher total costs of hospitalization ($40,875) compared with non-frail patients ($31,667). Frailty is an independent predictor of hepatic encephalopathy and in-patient mortality. Frailty is a surrogate marker of hospital length of stay and cost.
format	article
author	Daryl Ramai Khoi P. Dang-Ho Anjali Kewalramani Praneeth Bandaru Rodolfo Sacco Luca Giacomelli Aashni Shah Simonetta Papa Francesca Cappellini Fabio Perversi Sara di Nunzio Antonio Facciorusso
author_facet	Daryl Ramai Khoi P. Dang-Ho Anjali Kewalramani Praneeth Bandaru Rodolfo Sacco Luca Giacomelli Aashni Shah Simonetta Papa Francesca Cappellini Fabio Perversi Sara di Nunzio Antonio Facciorusso
author_sort	Daryl Ramai
title	Hospital Frailty Risk Score Is Independently Associated with Mortality and Encephalopathy in Hospitalized Patients with Hepatocellular Carcinoma
title_short	Hospital Frailty Risk Score Is Independently Associated with Mortality and Encephalopathy in Hospitalized Patients with Hepatocellular Carcinoma
title_full	Hospital Frailty Risk Score Is Independently Associated with Mortality and Encephalopathy in Hospitalized Patients with Hepatocellular Carcinoma
title_fullStr	Hospital Frailty Risk Score Is Independently Associated with Mortality and Encephalopathy in Hospitalized Patients with Hepatocellular Carcinoma
title_full_unstemmed	Hospital Frailty Risk Score Is Independently Associated with Mortality and Encephalopathy in Hospitalized Patients with Hepatocellular Carcinoma
title_sort	hospital frailty risk score is independently associated with mortality and encephalopathy in hospitalized patients with hepatocellular carcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b0a05939b6ef4cc290f15d76cba697dc
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Hospital Frailty Risk Score Is Independently Associated with Mortality and Encephalopathy in Hospitalized Patients with Hepatocellular Carcinoma

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