Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation

Abstract Mitochondria are fundamental for metabolic homeostasis in all multicellular eukaryotes. In the nervous system, mitochondria-generated adenosine triphosphate (ATP) is required to establish appropriate electrochemical gradients and reliable synaptic transmission. Notably, several mitochondria...

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Autores principales:	Pedro Norat, Sauson Soldozy, Jennifer D. Sokolowski, Catherine M. Gorick, Jeyan S. Kumar, Youngrok Chae, Kaan Yağmurlu, Francesco Prada, Melanie Walker, Michael R. Levitt, Richard J. Price, Petr Tvrdik, M. Yashar S. Kalani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/b0a1c19e85e34debbdbd0050424db0b5
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spelling	oai:doaj.org-article:b0a1c19e85e34debbdbd0050424db0b52021-12-02T14:22:13ZMitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation10.1038/s41536-020-00107-x2057-3995https://doaj.org/article/b0a1c19e85e34debbdbd0050424db0b52020-11-01T00:00:00Zhttps://doi.org/10.1038/s41536-020-00107-xhttps://doaj.org/toc/2057-3995Abstract Mitochondria are fundamental for metabolic homeostasis in all multicellular eukaryotes. In the nervous system, mitochondria-generated adenosine triphosphate (ATP) is required to establish appropriate electrochemical gradients and reliable synaptic transmission. Notably, several mitochondrial defects have been identified in central nervous system disorders. Membrane leakage and electrolyte imbalances, pro-apoptotic pathway activation, and mitophagy are among the mechanisms implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington’s disease, as well as ischemic stroke. In this review, we summarize mitochondrial pathways that contribute to disease progression. Further, we discuss pathological states that damaged mitochondria impose on normal nervous system processes and explore new therapeutic approaches to mitochondrial diseases.Pedro NoratSauson SoldozyJennifer D. SokolowskiCatherine M. GorickJeyan S. KumarYoungrok ChaeKaan YağmurluFrancesco PradaMelanie WalkerMichael R. LevittRichard J. PricePetr TvrdikM. Yashar S. KalaniNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 5, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Pedro Norat Sauson Soldozy Jennifer D. Sokolowski Catherine M. Gorick Jeyan S. Kumar Youngrok Chae Kaan Yağmurlu Francesco Prada Melanie Walker Michael R. Levitt Richard J. Price Petr Tvrdik M. Yashar S. Kalani Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation
description	Abstract Mitochondria are fundamental for metabolic homeostasis in all multicellular eukaryotes. In the nervous system, mitochondria-generated adenosine triphosphate (ATP) is required to establish appropriate electrochemical gradients and reliable synaptic transmission. Notably, several mitochondrial defects have been identified in central nervous system disorders. Membrane leakage and electrolyte imbalances, pro-apoptotic pathway activation, and mitophagy are among the mechanisms implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington’s disease, as well as ischemic stroke. In this review, we summarize mitochondrial pathways that contribute to disease progression. Further, we discuss pathological states that damaged mitochondria impose on normal nervous system processes and explore new therapeutic approaches to mitochondrial diseases.
format	article
author	Pedro Norat Sauson Soldozy Jennifer D. Sokolowski Catherine M. Gorick Jeyan S. Kumar Youngrok Chae Kaan Yağmurlu Francesco Prada Melanie Walker Michael R. Levitt Richard J. Price Petr Tvrdik M. Yashar S. Kalani
author_facet	Pedro Norat Sauson Soldozy Jennifer D. Sokolowski Catherine M. Gorick Jeyan S. Kumar Youngrok Chae Kaan Yağmurlu Francesco Prada Melanie Walker Michael R. Levitt Richard J. Price Petr Tvrdik M. Yashar S. Kalani
author_sort	Pedro Norat
title	Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation
title_short	Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation
title_full	Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation
title_fullStr	Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation
title_full_unstemmed	Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation
title_sort	mitochondrial dysfunction in neurological disorders: exploring mitochondrial transplantation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b0a1c19e85e34debbdbd0050424db0b5
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Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation

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