Development and pilot of an online, personalized risk assessment tool for a breast cancer precision medicine trial

Abstract Breast cancer risk reduction has been validated by large-scale clinical trials, but uptake remains low. A risk communication tool could provide personalized risk-reduction information for high-risk women. A low-literacy-friendly, visual, and personalized tool was designed as part of the Wom...

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Autores principales:	Holly Keane, Yash S. Huilgol, Yiwey Shieh, Jeffrey A. Tice, Jeff Belkora, Karen Sepucha, W. Patrick Shibley, Tianyi Wang, Mandy Che, Deborah Goodman, Elissa Ozanne, Allison Stover Fiscalini, Laura J. Esserman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/b0a1f180ec6b4596afc1f8abf9a66a74
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spelling	oai:doaj.org-article:b0a1f180ec6b4596afc1f8abf9a66a742021-12-02T17:40:30ZDevelopment and pilot of an online, personalized risk assessment tool for a breast cancer precision medicine trial10.1038/s41523-021-00288-82374-4677https://doaj.org/article/b0a1f180ec6b4596afc1f8abf9a66a742021-06-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00288-8https://doaj.org/toc/2374-4677Abstract Breast cancer risk reduction has been validated by large-scale clinical trials, but uptake remains low. A risk communication tool could provide personalized risk-reduction information for high-risk women. A low-literacy-friendly, visual, and personalized tool was designed as part of the Women Informed to Screen Depending On Measures of risk (WISDOM) study. The tool integrates genetic, polygenic, and lifestyle factors, and quantifies the risk-reduction from undertaking medication and lifestyle interventions. The development and design process utilized feedback from clinicians, decision-making scientists, software engineers, and patient advocates. We piloted the tool with 17 study participants, collecting quantitative and qualitative feedback. Overall, participants felt they better understood their personalized breast cancer risk, were motivated to reduce their risk, and considered lifestyle interventions. The tool will be used to evaluate whether risk-based screening leads to more informed decisions and higher uptake of risk-reduction interventions among those most likely to benefit.Holly KeaneYash S. HuilgolYiwey ShiehJeffrey A. TiceJeff BelkoraKaren SepuchaW. Patrick ShibleyTianyi WangMandy CheDeborah GoodmanElissa OzanneAllison Stover FiscaliniLaura J. EssermanNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Holly Keane Yash S. Huilgol Yiwey Shieh Jeffrey A. Tice Jeff Belkora Karen Sepucha W. Patrick Shibley Tianyi Wang Mandy Che Deborah Goodman Elissa Ozanne Allison Stover Fiscalini Laura J. Esserman Development and pilot of an online, personalized risk assessment tool for a breast cancer precision medicine trial
description	Abstract Breast cancer risk reduction has been validated by large-scale clinical trials, but uptake remains low. A risk communication tool could provide personalized risk-reduction information for high-risk women. A low-literacy-friendly, visual, and personalized tool was designed as part of the Women Informed to Screen Depending On Measures of risk (WISDOM) study. The tool integrates genetic, polygenic, and lifestyle factors, and quantifies the risk-reduction from undertaking medication and lifestyle interventions. The development and design process utilized feedback from clinicians, decision-making scientists, software engineers, and patient advocates. We piloted the tool with 17 study participants, collecting quantitative and qualitative feedback. Overall, participants felt they better understood their personalized breast cancer risk, were motivated to reduce their risk, and considered lifestyle interventions. The tool will be used to evaluate whether risk-based screening leads to more informed decisions and higher uptake of risk-reduction interventions among those most likely to benefit.
format	article
author	Holly Keane Yash S. Huilgol Yiwey Shieh Jeffrey A. Tice Jeff Belkora Karen Sepucha W. Patrick Shibley Tianyi Wang Mandy Che Deborah Goodman Elissa Ozanne Allison Stover Fiscalini Laura J. Esserman
author_facet	Holly Keane Yash S. Huilgol Yiwey Shieh Jeffrey A. Tice Jeff Belkora Karen Sepucha W. Patrick Shibley Tianyi Wang Mandy Che Deborah Goodman Elissa Ozanne Allison Stover Fiscalini Laura J. Esserman
author_sort	Holly Keane
title	Development and pilot of an online, personalized risk assessment tool for a breast cancer precision medicine trial
title_short	Development and pilot of an online, personalized risk assessment tool for a breast cancer precision medicine trial
title_full	Development and pilot of an online, personalized risk assessment tool for a breast cancer precision medicine trial
title_fullStr	Development and pilot of an online, personalized risk assessment tool for a breast cancer precision medicine trial
title_full_unstemmed	Development and pilot of an online, personalized risk assessment tool for a breast cancer precision medicine trial
title_sort	development and pilot of an online, personalized risk assessment tool for a breast cancer precision medicine trial
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b0a1f180ec6b4596afc1f8abf9a66a74
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Development and pilot of an online, personalized risk assessment tool for a breast cancer precision medicine trial

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