Determining the burden of fungal infections in Zimbabwe

Abstract Zimbabwe currently faces several healthcare challenges, most notably HIV and associated infections including tuberculosis (TB), malaria and recently outbreaks of cholera, typhoid fever and COVID-19. Fungal infections, which are also a major public health threat, receive considerably less at...

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Autores principales:	Lorraine T. Pfavayi, David W. Denning, Stephen Baker, Elopy N. Sibanda, Francisca Mutapi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b0a392b1a0bc4294ab8aacc13374c9c4
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spelling	oai:doaj.org-article:b0a392b1a0bc4294ab8aacc13374c9c42021-12-02T18:02:43ZDetermining the burden of fungal infections in Zimbabwe10.1038/s41598-021-92605-12045-2322https://doaj.org/article/b0a392b1a0bc4294ab8aacc13374c9c42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92605-1https://doaj.org/toc/2045-2322Abstract Zimbabwe currently faces several healthcare challenges, most notably HIV and associated infections including tuberculosis (TB), malaria and recently outbreaks of cholera, typhoid fever and COVID-19. Fungal infections, which are also a major public health threat, receive considerably less attention. Consequently, there is dearth of data regarding the burden of fungal diseases in the country. We estimated the burden of fungal diseases in Zimbabwe based on published literature and ‘at-risk’ populations (HIV/AIDS patients, survivors of pulmonary TB, cancer, chronic obstructive pulmonary disease, asthma and patients receiving critical care) using previously described methods. Where there was no data for Zimbabwe, regional, or international data was used. Our study revealed that approximately 14.9% of Zimbabweans suffer from fungal infections annually, with 80% having tinea capitis. The annual incidence of cryptococcal meningitis and Pneumocystis jirovecii pneumonia in HIV/AIDS were estimated at 41/100,000 and 63/100,000, respectively. The estimated prevalence of recurrent vulvovaginal candidiasis (RVVC) was 2,739/100,000. The estimated burden of fungal diseases in Zimbabwe is high in comparison to other African countries, highlighting the urgent need for increased awareness and surveillance to improve diagnosis and management.Lorraine T. PfavayiDavid W. DenningStephen BakerElopy N. SibandaFrancisca MutapiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lorraine T. Pfavayi David W. Denning Stephen Baker Elopy N. Sibanda Francisca Mutapi Determining the burden of fungal infections in Zimbabwe
description	Abstract Zimbabwe currently faces several healthcare challenges, most notably HIV and associated infections including tuberculosis (TB), malaria and recently outbreaks of cholera, typhoid fever and COVID-19. Fungal infections, which are also a major public health threat, receive considerably less attention. Consequently, there is dearth of data regarding the burden of fungal diseases in the country. We estimated the burden of fungal diseases in Zimbabwe based on published literature and ‘at-risk’ populations (HIV/AIDS patients, survivors of pulmonary TB, cancer, chronic obstructive pulmonary disease, asthma and patients receiving critical care) using previously described methods. Where there was no data for Zimbabwe, regional, or international data was used. Our study revealed that approximately 14.9% of Zimbabweans suffer from fungal infections annually, with 80% having tinea capitis. The annual incidence of cryptococcal meningitis and Pneumocystis jirovecii pneumonia in HIV/AIDS were estimated at 41/100,000 and 63/100,000, respectively. The estimated prevalence of recurrent vulvovaginal candidiasis (RVVC) was 2,739/100,000. The estimated burden of fungal diseases in Zimbabwe is high in comparison to other African countries, highlighting the urgent need for increased awareness and surveillance to improve diagnosis and management.
format	article
author	Lorraine T. Pfavayi David W. Denning Stephen Baker Elopy N. Sibanda Francisca Mutapi
author_facet	Lorraine T. Pfavayi David W. Denning Stephen Baker Elopy N. Sibanda Francisca Mutapi
author_sort	Lorraine T. Pfavayi
title	Determining the burden of fungal infections in Zimbabwe
title_short	Determining the burden of fungal infections in Zimbabwe
title_full	Determining the burden of fungal infections in Zimbabwe
title_fullStr	Determining the burden of fungal infections in Zimbabwe
title_full_unstemmed	Determining the burden of fungal infections in Zimbabwe
title_sort	determining the burden of fungal infections in zimbabwe
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b0a392b1a0bc4294ab8aacc13374c9c4
work_keys_str_mv	AT lorrainetpfavayi determiningtheburdenoffungalinfectionsinzimbabwe AT davidwdenning determiningtheburdenoffungalinfectionsinzimbabwe AT stephenbaker determiningtheburdenoffungalinfectionsinzimbabwe AT elopynsibanda determiningtheburdenoffungalinfectionsinzimbabwe AT franciscamutapi determiningtheburdenoffungalinfectionsinzimbabwe
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Determining the burden of fungal infections in Zimbabwe

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