A Comprehensive Review on the Biomarkers of Bone Remodeling in Vitamin D Deficiency

Vitamin D (Vit.D) has been well regarded as one of the essential micronutrients for several biological functions in humans, including bone structure and function. The deficiency of Vit.D due to various environmental, lifestyle, and genetic factors affect bone remodeling, including bone mineralizatio...

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Autores principales:	Krishna Veni Nagappan, Arti Sureshkumar
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2021
Materias:	vitamin d, bone remodeling, bone resorption, bone mineralization, biomarkers, osteoporosis Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/b0a59c6d45934947ab5ea9d8712145f8
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spelling	oai:doaj.org-article:b0a59c6d45934947ab5ea9d8712145f82021-11-15T06:08:46ZA Comprehensive Review on the Biomarkers of Bone Remodeling in Vitamin D Deficiency2338-94272338-948610.22146/ijp.1792https://doaj.org/article/b0a59c6d45934947ab5ea9d8712145f82021-09-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/1792https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486Vitamin D (Vit.D) has been well regarded as one of the essential micronutrients for several biological functions in humans, including bone structure and function. The deficiency of Vit.D due to various environmental, lifestyle, and genetic factors affect bone remodeling, including bone mineralization and resorption. Consequently, several changes occur in the level of biochemicals which are implied in bone remodeling, either directly or via secondary pathways. Intriguingly, the levels of these biomolecules are hypothesized to have a strong association with the prognosis of Vit. D deficiency (VDD) related health complications. However, the precise association of various bone turnover-derived biomolecules with VDD-related effects are largely elusive. Thus, the in-depth understanding of specific associations of VDD and bone mineralization, would establish novel bioanalytical approaches for early detection and devise alternative strategies to provide symptomatic clinical support to VDD patients. Hence this review collates the available literature to elucidate the association of various bone resorption biomarkers and their relevance to VDD.Krishna Veni NagappanArti SureshkumarUniversitas Gadjah Madaarticlevitamin d, bone remodeling, bone resorption, bone mineralization, biomarkers, osteoporosisPharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 280-290 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin d, bone remodeling, bone resorption, bone mineralization, biomarkers, osteoporosis Pharmacy and materia medica RS1-441
spellingShingle	vitamin d, bone remodeling, bone resorption, bone mineralization, biomarkers, osteoporosis Pharmacy and materia medica RS1-441 Krishna Veni Nagappan Arti Sureshkumar A Comprehensive Review on the Biomarkers of Bone Remodeling in Vitamin D Deficiency
description	Vitamin D (Vit.D) has been well regarded as one of the essential micronutrients for several biological functions in humans, including bone structure and function. The deficiency of Vit.D due to various environmental, lifestyle, and genetic factors affect bone remodeling, including bone mineralization and resorption. Consequently, several changes occur in the level of biochemicals which are implied in bone remodeling, either directly or via secondary pathways. Intriguingly, the levels of these biomolecules are hypothesized to have a strong association with the prognosis of Vit. D deficiency (VDD) related health complications. However, the precise association of various bone turnover-derived biomolecules with VDD-related effects are largely elusive. Thus, the in-depth understanding of specific associations of VDD and bone mineralization, would establish novel bioanalytical approaches for early detection and devise alternative strategies to provide symptomatic clinical support to VDD patients. Hence this review collates the available literature to elucidate the association of various bone resorption biomarkers and their relevance to VDD.
format	article
author	Krishna Veni Nagappan Arti Sureshkumar
author_facet	Krishna Veni Nagappan Arti Sureshkumar
author_sort	Krishna Veni Nagappan
title	A Comprehensive Review on the Biomarkers of Bone Remodeling in Vitamin D Deficiency
title_short	A Comprehensive Review on the Biomarkers of Bone Remodeling in Vitamin D Deficiency
title_full	A Comprehensive Review on the Biomarkers of Bone Remodeling in Vitamin D Deficiency
title_fullStr	A Comprehensive Review on the Biomarkers of Bone Remodeling in Vitamin D Deficiency
title_full_unstemmed	A Comprehensive Review on the Biomarkers of Bone Remodeling in Vitamin D Deficiency
title_sort	comprehensive review on the biomarkers of bone remodeling in vitamin d deficiency
publisher	Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/b0a59c6d45934947ab5ea9d8712145f8
work_keys_str_mv	AT krishnaveninagappan acomprehensivereviewonthebiomarkersofboneremodelinginvitaminddeficiency AT artisureshkumar acomprehensivereviewonthebiomarkersofboneremodelinginvitaminddeficiency AT krishnaveninagappan comprehensivereviewonthebiomarkersofboneremodelinginvitaminddeficiency AT artisureshkumar comprehensivereviewonthebiomarkersofboneremodelinginvitaminddeficiency
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A Comprehensive Review on the Biomarkers of Bone Remodeling in Vitamin D Deficiency

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