Genome-wide specificity of dCpf1 cytidine base editors

Cas12a-linked base editors can broaden the targeting scope of programmable cytidine deaminases. Here the authors assess their target specificity in an in vitro genome-wide assay.

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Bibliographic Details
Main Authors: Daesik Kim, Kayeong Lim, Da-eun Kim, Jin-Soo Kim
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/b0a64a1338ff4e0885c245ba597b7e03
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Description
Summary:Cas12a-linked base editors can broaden the targeting scope of programmable cytidine deaminases. Here the authors assess their target specificity in an in vitro genome-wide assay.