Genome-wide specificity of dCpf1 cytidine base editors

Genome-wide specificity of dCpf1 cytidine base editors

Cas12a-linked base editors can broaden the targeting scope of programmable cytidine deaminases. Here the authors assess their target specificity in an in vitro genome-wide assay.

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Autores principales: Daesik Kim, Kayeong Lim, Da-eun Kim, Jin-Soo Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
Q
Acceso en línea:https://doaj.org/article/b0a64a1338ff4e0885c245ba597b7e03
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spelling oai:doaj.org-article:b0a64a1338ff4e0885c245ba597b7e032021-12-02T18:50:45ZGenome-wide specificity of dCpf1 cytidine base editors10.1038/s41467-020-17889-92041-1723https://doaj.org/article/b0a64a1338ff4e0885c245ba597b7e032020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17889-9https://doaj.org/toc/2041-1723Cas12a-linked base editors can broaden the targeting scope of programmable cytidine deaminases. Here the authors assess their target specificity in an in vitro genome-wide assay.Daesik KimKayeong LimDa-eun KimJin-Soo KimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Daesik Kim
Kayeong Lim
Da-eun Kim
Jin-Soo Kim
Genome-wide specificity of dCpf1 cytidine base editors
description Cas12a-linked base editors can broaden the targeting scope of programmable cytidine deaminases. Here the authors assess their target specificity in an in vitro genome-wide assay.
format article
author Daesik Kim
Kayeong Lim
Da-eun Kim
Jin-Soo Kim
author_facet Daesik Kim
Kayeong Lim
Da-eun Kim
Jin-Soo Kim
author_sort Daesik Kim
title Genome-wide specificity of dCpf1 cytidine base editors
title_short Genome-wide specificity of dCpf1 cytidine base editors
title_full Genome-wide specificity of dCpf1 cytidine base editors
title_fullStr Genome-wide specificity of dCpf1 cytidine base editors
title_full_unstemmed Genome-wide specificity of dCpf1 cytidine base editors
title_sort genome-wide specificity of dcpf1 cytidine base editors
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/b0a64a1338ff4e0885c245ba597b7e03
work_keys_str_mv AT daesikkim genomewidespecificityofdcpf1cytidinebaseeditors
AT kayeonglim genomewidespecificityofdcpf1cytidinebaseeditors
AT daeunkim genomewidespecificityofdcpf1cytidinebaseeditors
AT jinsookim genomewidespecificityofdcpf1cytidinebaseeditors
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