Dramatic increases in blood glutamate concentrations are closely related to traumatic brain injury-induced acute lung injury

Abstract Traumatic brain injury-induced acute lung injury (TBI-ALI) is a serious complication after brain injury for which predictive factors are lacking. In this study, we found significantly elevated blood glutamate concentrations in patients with TBI or multiple peripheral trauma (MPT), and patie...

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Autores principales:	Wei Bai, Wan-Li Zhu, Ya-Lei Ning, Ping Li, Yan Zhao, Nan Yang, Xing Chen, Yu-Lin Jiang, Wen-Qun Yang, Dong-Po Jiang, Li-Yong Chen, Yuan-Guo Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b0a793080e6b411dbe04569a0fcf3a23
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spelling	oai:doaj.org-article:b0a793080e6b411dbe04569a0fcf3a232021-12-02T11:52:26ZDramatic increases in blood glutamate concentrations are closely related to traumatic brain injury-induced acute lung injury10.1038/s41598-017-05574-92045-2322https://doaj.org/article/b0a793080e6b411dbe04569a0fcf3a232017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05574-9https://doaj.org/toc/2045-2322Abstract Traumatic brain injury-induced acute lung injury (TBI-ALI) is a serious complication after brain injury for which predictive factors are lacking. In this study, we found significantly elevated blood glutamate concentrations in patients with TBI or multiple peripheral trauma (MPT), and patients with more severe injuries showed higher blood glutamate concentrations and longer durations of elevated levels. Although the increase in amplitude was similar between the two groups, the duration was longer in the patients with TBI. There were no significant differences in blood glutamate concentrations in the patients with MPT with regard to ALI status, but the blood glutamate levels were significantly higher in the patients with TBI-ALI than in those without ALI. Moreover, compared to patients without ALI, patients with TBI showed a clearly enhanced inflammatory response that was closely correlated with the blood glutamate levels. The blood glutamate concentration was also found to be a risk factor (adjusted odds ratio, 2.229; 95% CI, 1.082–2.634) and was a better predictor of TBI-ALI than the Glasgow Coma Scale (GCS) score. These results indicated that dramatically increased blood glutamate concentrations were closely related to the occurrence of TBI-ALI and could be used as a predictive marker for “at-risk” patients.Wei BaiWan-Li ZhuYa-Lei NingPing LiYan ZhaoNan YangXing ChenYu-Lin JiangWen-Qun YangDong-Po JiangLi-Yong ChenYuan-Guo ZhouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei Bai Wan-Li Zhu Ya-Lei Ning Ping Li Yan Zhao Nan Yang Xing Chen Yu-Lin Jiang Wen-Qun Yang Dong-Po Jiang Li-Yong Chen Yuan-Guo Zhou Dramatic increases in blood glutamate concentrations are closely related to traumatic brain injury-induced acute lung injury
description	Abstract Traumatic brain injury-induced acute lung injury (TBI-ALI) is a serious complication after brain injury for which predictive factors are lacking. In this study, we found significantly elevated blood glutamate concentrations in patients with TBI or multiple peripheral trauma (MPT), and patients with more severe injuries showed higher blood glutamate concentrations and longer durations of elevated levels. Although the increase in amplitude was similar between the two groups, the duration was longer in the patients with TBI. There were no significant differences in blood glutamate concentrations in the patients with MPT with regard to ALI status, but the blood glutamate levels were significantly higher in the patients with TBI-ALI than in those without ALI. Moreover, compared to patients without ALI, patients with TBI showed a clearly enhanced inflammatory response that was closely correlated with the blood glutamate levels. The blood glutamate concentration was also found to be a risk factor (adjusted odds ratio, 2.229; 95% CI, 1.082–2.634) and was a better predictor of TBI-ALI than the Glasgow Coma Scale (GCS) score. These results indicated that dramatically increased blood glutamate concentrations were closely related to the occurrence of TBI-ALI and could be used as a predictive marker for “at-risk” patients.
format	article
author	Wei Bai Wan-Li Zhu Ya-Lei Ning Ping Li Yan Zhao Nan Yang Xing Chen Yu-Lin Jiang Wen-Qun Yang Dong-Po Jiang Li-Yong Chen Yuan-Guo Zhou
author_facet	Wei Bai Wan-Li Zhu Ya-Lei Ning Ping Li Yan Zhao Nan Yang Xing Chen Yu-Lin Jiang Wen-Qun Yang Dong-Po Jiang Li-Yong Chen Yuan-Guo Zhou
author_sort	Wei Bai
title	Dramatic increases in blood glutamate concentrations are closely related to traumatic brain injury-induced acute lung injury
title_short	Dramatic increases in blood glutamate concentrations are closely related to traumatic brain injury-induced acute lung injury
title_full	Dramatic increases in blood glutamate concentrations are closely related to traumatic brain injury-induced acute lung injury
title_fullStr	Dramatic increases in blood glutamate concentrations are closely related to traumatic brain injury-induced acute lung injury
title_full_unstemmed	Dramatic increases in blood glutamate concentrations are closely related to traumatic brain injury-induced acute lung injury
title_sort	dramatic increases in blood glutamate concentrations are closely related to traumatic brain injury-induced acute lung injury
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b0a793080e6b411dbe04569a0fcf3a23
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Dramatic increases in blood glutamate concentrations are closely related to traumatic brain injury-induced acute lung injury

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