A simple two-state protein unfolds mechanically via multiple heterogeneous pathways at single-molecule resolution
Previous investigations have indicated that the model protein CspB folds in a simple two-state fashion. Here, the authors provide direct experimental evidence for that the energy landscape of two-state folding proteins is highly heterogeneous and that unfolding can occur via multiple pathways.
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Nature Portfolio
2016
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oai:doaj.org-article:b0aaa035d8944396b1adbf1983ac4d332021-12-02T16:56:44ZA simple two-state protein unfolds mechanically via multiple heterogeneous pathways at single-molecule resolution10.1038/ncomms117772041-1723https://doaj.org/article/b0aaa035d8944396b1adbf1983ac4d332016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11777https://doaj.org/toc/2041-1723Previous investigations have indicated that the model protein CspB folds in a simple two-state fashion. Here, the authors provide direct experimental evidence for that the energy landscape of two-state folding proteins is highly heterogeneous and that unfolding can occur via multiple pathways.Jörg SchönfelderRaul Perez-JimenezVictor MuñozNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Jörg Schönfelder Raul Perez-Jimenez Victor Muñoz A simple two-state protein unfolds mechanically via multiple heterogeneous pathways at single-molecule resolution |
| description |
Previous investigations have indicated that the model protein CspB folds in a simple two-state fashion. Here, the authors provide direct experimental evidence for that the energy landscape of two-state folding proteins is highly heterogeneous and that unfolding can occur via multiple pathways. |
| format |
article |
| author |
Jörg Schönfelder Raul Perez-Jimenez Victor Muñoz |
| author_facet |
Jörg Schönfelder Raul Perez-Jimenez Victor Muñoz |
| author_sort |
Jörg Schönfelder |
| title |
A simple two-state protein unfolds mechanically via multiple heterogeneous pathways at single-molecule resolution |
| title_short |
A simple two-state protein unfolds mechanically via multiple heterogeneous pathways at single-molecule resolution |
| title_full |
A simple two-state protein unfolds mechanically via multiple heterogeneous pathways at single-molecule resolution |
| title_fullStr |
A simple two-state protein unfolds mechanically via multiple heterogeneous pathways at single-molecule resolution |
| title_full_unstemmed |
A simple two-state protein unfolds mechanically via multiple heterogeneous pathways at single-molecule resolution |
| title_sort |
simple two-state protein unfolds mechanically via multiple heterogeneous pathways at single-molecule resolution |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/b0aaa035d8944396b1adbf1983ac4d33 |
| work_keys_str_mv |
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| _version_ |
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