No association between dopamine D3 receptor gene Ser9Gly polymorphism (rs6280) and risk of schizophrenia: an updated meta-analysis

Xing-ling Qi, Jin-feng Xuan, Jia-xin Xing, Bao-jie Wang, Jun Yao School of Forensic Medicine, China Medical University, Shenyang, People’s Republic of China Objective: Ser9Gly (rs6280) is a functional single-nucleotide polymorphism (SNP) in the dopamine receptor D3 (DRD3) gene that may b...

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Autores principales:	Qi XL, Xuan JF, Xing JX, Wang BJ, Yao J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Dopamine receptor D3 Schizophrenia Meta-analysis Gene polymorphism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b0ae69aebb1b48f8a1b80b4d94c9a9ee
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spelling	oai:doaj.org-article:b0ae69aebb1b48f8a1b80b4d94c9a9ee2021-12-02T04:45:39ZNo association between dopamine D3 receptor gene Ser9Gly polymorphism (rs6280) and risk of schizophrenia: an updated meta-analysis1178-2021https://doaj.org/article/b0ae69aebb1b48f8a1b80b4d94c9a9ee2017-11-01T00:00:00Zhttps://www.dovepress.com/no-association-between-dopamine-d3-receptor-gene-ser9gly-polymorphism--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xing-ling Qi, Jin-feng Xuan, Jia-xin Xing, Bao-jie Wang, Jun Yao School of Forensic Medicine, China Medical University, Shenyang, People’s Republic of China Objective: Ser9Gly (rs6280) is a functional single-nucleotide polymorphism (SNP) in the dopamine receptor D3 (DRD3) gene that may be associated with schizophrenia. We performed a meta-analysis to determine whether Ser9Gly influences the risk of schizophrenia and examined the relationship between the Ser9Gly SNP and the etiology of schizophrenia.Methods: Case–control studies were retrieved from literature databases in accordance with established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between Ser9Gly and schizophrenia. Subgroup analysis and sensitivity analysis were also performed.Results: Seventy-three studies comprising 10,634 patients with schizophrenia (cases) and 11,258 controls were included in this meta-analysis. Summary results indicated no association between Ser9Gly and risk of schizophrenia. In the dominant genetic model, the pooled OR using a random effects model was 0.950 (95% CI, 0.847–1.064; P=0.374).Conclusion: Results of this meta-analysis suggest that the Ser9Gly SNP is not associated with schizophrenia. These data provide possible avenues for future case–control studies related to schizophrenia. Keywords: dopamine receptor D3, schizophrenia, meta-analysis, gene polymorphismQi XLXuan JFXing JXWang BJYao JDove Medical PressarticleDopamine receptor D3SchizophreniaMeta-analysisGene polymorphismNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2855-2865 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dopamine receptor D3 Schizophrenia Meta-analysis Gene polymorphism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Dopamine receptor D3 Schizophrenia Meta-analysis Gene polymorphism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Qi XL Xuan JF Xing JX Wang BJ Yao J No association between dopamine D3 receptor gene Ser9Gly polymorphism (rs6280) and risk of schizophrenia: an updated meta-analysis
description	Xing-ling Qi, Jin-feng Xuan, Jia-xin Xing, Bao-jie Wang, Jun Yao School of Forensic Medicine, China Medical University, Shenyang, People’s Republic of China Objective: Ser9Gly (rs6280) is a functional single-nucleotide polymorphism (SNP) in the dopamine receptor D3 (DRD3) gene that may be associated with schizophrenia. We performed a meta-analysis to determine whether Ser9Gly influences the risk of schizophrenia and examined the relationship between the Ser9Gly SNP and the etiology of schizophrenia.Methods: Case–control studies were retrieved from literature databases in accordance with established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the association between Ser9Gly and schizophrenia. Subgroup analysis and sensitivity analysis were also performed.Results: Seventy-three studies comprising 10,634 patients with schizophrenia (cases) and 11,258 controls were included in this meta-analysis. Summary results indicated no association between Ser9Gly and risk of schizophrenia. In the dominant genetic model, the pooled OR using a random effects model was 0.950 (95% CI, 0.847–1.064; P=0.374).Conclusion: Results of this meta-analysis suggest that the Ser9Gly SNP is not associated with schizophrenia. These data provide possible avenues for future case–control studies related to schizophrenia. Keywords: dopamine receptor D3, schizophrenia, meta-analysis, gene polymorphism
format	article
author	Qi XL Xuan JF Xing JX Wang BJ Yao J
author_facet	Qi XL Xuan JF Xing JX Wang BJ Yao J
author_sort	Qi XL
title	No association between dopamine D3 receptor gene Ser9Gly polymorphism (rs6280) and risk of schizophrenia: an updated meta-analysis
title_short	No association between dopamine D3 receptor gene Ser9Gly polymorphism (rs6280) and risk of schizophrenia: an updated meta-analysis
title_full	No association between dopamine D3 receptor gene Ser9Gly polymorphism (rs6280) and risk of schizophrenia: an updated meta-analysis
title_fullStr	No association between dopamine D3 receptor gene Ser9Gly polymorphism (rs6280) and risk of schizophrenia: an updated meta-analysis
title_full_unstemmed	No association between dopamine D3 receptor gene Ser9Gly polymorphism (rs6280) and risk of schizophrenia: an updated meta-analysis
title_sort	no association between dopamine d3 receptor gene ser9gly polymorphism (rs6280) and risk of schizophrenia: an updated meta-analysis
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/b0ae69aebb1b48f8a1b80b4d94c9a9ee
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No association between dopamine D3 receptor gene Ser9Gly polymorphism (rs6280) and risk of schizophrenia: an updated meta-analysis

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