In patients with neovascular age-related macular degeneration, physical activity may influence C-reactive protein levels

Yousif Subhi, Amardeep Singh, Mads Krüger Falk, Torben Lykke SørensenDepartment of Ophthalmology, Clinical Eye Research Unit, Copenhagen University Hospital Roskilde and the University of Copenhagen, Copenhagen, DenmarkPurpose: Association of neovascular age-related macular degen...

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Autores principales:	Subhi Y, Singh A, Falk MK, S&oslash;rensen TL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/b0b0716a5e55493ba6feac3ae8a22210
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spelling	oai:doaj.org-article:b0b0716a5e55493ba6feac3ae8a222102021-12-02T02:55:42ZIn patients with neovascular age-related macular degeneration, physical activity may influence C-reactive protein levels1177-54671177-5483https://doaj.org/article/b0b0716a5e55493ba6feac3ae8a222102013-12-01T00:00:00Zhttp://www.dovepress.com/in-patients-with-neovascular-age-related-macular-degeneration-physical-a15232https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Yousif Subhi, Amardeep Singh, Mads Krüger Falk, Torben Lykke SørensenDepartment of Ophthalmology, Clinical Eye Research Unit, Copenhagen University Hospital Roskilde and the University of Copenhagen, Copenhagen, DenmarkPurpose: Association of neovascular age-related macular degeneration (AMD) with C-reactive protein (CRP) was previously reported, indicating a relation to systemic low-grade inflammation. However, visual impairment limits physical activity, and physical activity modulates CRP levels. Here, we investigated the impact of physical activity on CRP levels in patients with neovascular AMD and control individuals.Subjects and methods: We recruited participants from our outpatient AMD program, and control individuals from non-AMD patients, visitors, and department staff. After initial screening of 191 individuals, we included 98 patients with neovascular AMD and 77 controls. All were screened using digital fundus photography and optical coherence tomography, and interviewed about medical history and physical activity. Venous blood samples were obtained for high-sensitivity CRP.Results: Physically active individuals had lower CRP than physically inactive individuals (P=0.003), and physical activity was associated with lower CRP in patients (P=0.038) and controls (P=0.031). Patients and controls did not differ in percentage physically active (P=0.807) or in overall CRP levels (P=0.394). The independent contribution of physical activity on CRP was confirmed in a multiple regression analysis (P=0.009), in which the presence of neovascular AMD did not contribute significantly (P=0.913).Conclusion: Our findings suggest that elevated CRP levels in patients with neovascular AMD are at least partly explained by physical inactivity. Future studies of systemic inflammation among the visually impaired should include disease-related implications, such as the impact of physical activity.Keywords: age-related macular degeneration, physical activity, C-reactive proteinSubhi YSingh AFalk MKS&oslash;rensen TLDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 15-21 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Subhi Y Singh A Falk MK S&oslash;rensen TL In patients with neovascular age-related macular degeneration, physical activity may influence C-reactive protein levels
description	Yousif Subhi, Amardeep Singh, Mads Krüger Falk, Torben Lykke SørensenDepartment of Ophthalmology, Clinical Eye Research Unit, Copenhagen University Hospital Roskilde and the University of Copenhagen, Copenhagen, DenmarkPurpose: Association of neovascular age-related macular degeneration (AMD) with C-reactive protein (CRP) was previously reported, indicating a relation to systemic low-grade inflammation. However, visual impairment limits physical activity, and physical activity modulates CRP levels. Here, we investigated the impact of physical activity on CRP levels in patients with neovascular AMD and control individuals.Subjects and methods: We recruited participants from our outpatient AMD program, and control individuals from non-AMD patients, visitors, and department staff. After initial screening of 191 individuals, we included 98 patients with neovascular AMD and 77 controls. All were screened using digital fundus photography and optical coherence tomography, and interviewed about medical history and physical activity. Venous blood samples were obtained for high-sensitivity CRP.Results: Physically active individuals had lower CRP than physically inactive individuals (P=0.003), and physical activity was associated with lower CRP in patients (P=0.038) and controls (P=0.031). Patients and controls did not differ in percentage physically active (P=0.807) or in overall CRP levels (P=0.394). The independent contribution of physical activity on CRP was confirmed in a multiple regression analysis (P=0.009), in which the presence of neovascular AMD did not contribute significantly (P=0.913).Conclusion: Our findings suggest that elevated CRP levels in patients with neovascular AMD are at least partly explained by physical inactivity. Future studies of systemic inflammation among the visually impaired should include disease-related implications, such as the impact of physical activity.Keywords: age-related macular degeneration, physical activity, C-reactive protein
format	article
author	Subhi Y Singh A Falk MK S&oslash;rensen TL
author_facet	Subhi Y Singh A Falk MK S&oslash;rensen TL
author_sort	Subhi Y
title	In patients with neovascular age-related macular degeneration, physical activity may influence C-reactive protein levels
title_short	In patients with neovascular age-related macular degeneration, physical activity may influence C-reactive protein levels
title_full	In patients with neovascular age-related macular degeneration, physical activity may influence C-reactive protein levels
title_fullStr	In patients with neovascular age-related macular degeneration, physical activity may influence C-reactive protein levels
title_full_unstemmed	In patients with neovascular age-related macular degeneration, physical activity may influence C-reactive protein levels
title_sort	in patients with neovascular age-related macular degeneration, physical activity may influence c-reactive protein levels
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/b0b0716a5e55493ba6feac3ae8a22210
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In patients with neovascular age-related macular degeneration, physical activity may influence C-reactive protein levels

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