Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase

Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase

The SARS-CoV-2 NSP13 helicase is essential for viral replication and of interest as a drug target. Here, the authors present the crystal structures of NSP13 in the apo form and bound to either phosphate or the non-hydrolysable ATP analog AMP-PNP and discuss the helicase mechanism. They also perform...

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Autores principales: Joseph A. Newman, Alice Douangamath, Setayesh Yadzani, Yuliana Yosaatmadja, Antony Aimon, José Brandão-Neto, Louise Dunnett, Tyler Gorrie-stone, Rachael Skyner, Daren Fearon, Matthieu Schapira, Frank von Delft, Opher Gileadi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/b0b0d159fff646579ffb503d1f3b7821
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