Metabolic aspects of diabetes mellitus type 1 in representatives of different ethnic groups

Background. Oxidative stress is an acknowledged pathogenic mechanism in diabetes mellitus type 1. Incidence, severity, and rate of complications of diabetes mellitus type 1 are associated with many factors including geographic location and ethnicity. Material and methods. The features of POL-AOD pro...

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Autores principales:	M. A. Darenskaya, L. A. Grebyonkina, S. V. Gnusina
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	diabetes mellitus type 1 lipid peroxidation lactate ethnic group Science Q
Acceso en línea:	https://doaj.org/article/b0bb8242c08c4f7785600bb9d3b25eb3
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spelling	oai:doaj.org-article:b0bb8242c08c4f7785600bb9d3b25eb32021-11-23T06:14:34ZMetabolic aspects of diabetes mellitus type 1 in representatives of different ethnic groups2541-94202587-959610.12737/article_590823a4164105.67682152https://doaj.org/article/b0bb8242c08c4f7785600bb9d3b25eb32016-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/179https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Oxidative stress is an acknowledged pathogenic mechanism in diabetes mellitus type 1. Incidence, severity, and rate of complications of diabetes mellitus type 1 are associated with many factors including geographic location and ethnicity. Material and methods. The features of POL-AOD processes, the levels of lactate, pyruvate, and their relationships in 30 women of Buryat and Russian ethnic groups with diabetes mellitus type 1. The materials for biochemical studies were blood serum and red cells. Spectrophotometric and fluorometric methods were used. Results. Increase of lipid peroxidation activity at the initial stages and increase of total antioxidant blood activity in Buryat patients were marked. Increase of primary and secondary lipid peroxidation products concentrations and decrease of superoxide dismutase activity in group of Russian patients were marked. It is confirmed to the oxidative stress factor. The reduced concentration of lactate and the ratio lactate/pyruvate levels in patients Buryat ethnic group were observed. More intensive accumulation of lactate and ratio of lactate/pyruvate can contribute to hypoxic events and worsen the prognosis of the disease in Russian patients. Conclusions. It was found that the degree of intensity lipid peroxidation process and lactate and the ratio lactate/pyruvate levels in patients Buryat ethnic group reduced in comparison with Russian patients. This work was supported by grant of the President of Russian Federation (№ 5646.2014.7).M. A. DarenskayaL. A. GrebyonkinaS. V. GnusinaScientific Сentre for Family Health and Human Reproduction Problemsarticlediabetes mellitus type 1lipid peroxidationlactateethnic groupScienceQRUActa Biomedica Scientifica, Vol 1, Iss 3(2), Pp 20-25 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	diabetes mellitus type 1 lipid peroxidation lactate ethnic group Science Q
spellingShingle	diabetes mellitus type 1 lipid peroxidation lactate ethnic group Science Q M. A. Darenskaya L. A. Grebyonkina S. V. Gnusina Metabolic aspects of diabetes mellitus type 1 in representatives of different ethnic groups
description	Background. Oxidative stress is an acknowledged pathogenic mechanism in diabetes mellitus type 1. Incidence, severity, and rate of complications of diabetes mellitus type 1 are associated with many factors including geographic location and ethnicity. Material and methods. The features of POL-AOD processes, the levels of lactate, pyruvate, and their relationships in 30 women of Buryat and Russian ethnic groups with diabetes mellitus type 1. The materials for biochemical studies were blood serum and red cells. Spectrophotometric and fluorometric methods were used. Results. Increase of lipid peroxidation activity at the initial stages and increase of total antioxidant blood activity in Buryat patients were marked. Increase of primary and secondary lipid peroxidation products concentrations and decrease of superoxide dismutase activity in group of Russian patients were marked. It is confirmed to the oxidative stress factor. The reduced concentration of lactate and the ratio lactate/pyruvate levels in patients Buryat ethnic group were observed. More intensive accumulation of lactate and ratio of lactate/pyruvate can contribute to hypoxic events and worsen the prognosis of the disease in Russian patients. Conclusions. It was found that the degree of intensity lipid peroxidation process and lactate and the ratio lactate/pyruvate levels in patients Buryat ethnic group reduced in comparison with Russian patients. This work was supported by grant of the President of Russian Federation (№ 5646.2014.7).
format	article
author	M. A. Darenskaya L. A. Grebyonkina S. V. Gnusina
author_facet	M. A. Darenskaya L. A. Grebyonkina S. V. Gnusina
author_sort	M. A. Darenskaya
title	Metabolic aspects of diabetes mellitus type 1 in representatives of different ethnic groups
title_short	Metabolic aspects of diabetes mellitus type 1 in representatives of different ethnic groups
title_full	Metabolic aspects of diabetes mellitus type 1 in representatives of different ethnic groups
title_fullStr	Metabolic aspects of diabetes mellitus type 1 in representatives of different ethnic groups
title_full_unstemmed	Metabolic aspects of diabetes mellitus type 1 in representatives of different ethnic groups
title_sort	metabolic aspects of diabetes mellitus type 1 in representatives of different ethnic groups
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/b0bb8242c08c4f7785600bb9d3b25eb3
work_keys_str_mv	AT madarenskaya metabolicaspectsofdiabetesmellitustype1inrepresentativesofdifferentethnicgroups AT lagrebyonkina metabolicaspectsofdiabetesmellitustype1inrepresentativesofdifferentethnicgroups AT svgnusina metabolicaspectsofdiabetesmellitustype1inrepresentativesofdifferentethnicgroups
_version_	1718417091504111616

Metabolic aspects of diabetes mellitus type 1 in representatives of different ethnic groups

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