Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis
Na+-H+ exchanger 1 (Nhe1) regulates extracellular pH by extruding protons in exchange for extracellular Na+ . Here, Liu et al. show that Nhe1 promotes the development and acidification of atherosclerotic lesions and that pH-sensitive probes can be used to monitor plaque growth and acidification.
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Nature Portfolio
2019
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oai:doaj.org-article:b0bd30f23bbe46f4ac1f69c4a193d1c12021-12-02T16:57:45ZNa+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis10.1038/s41467-019-11983-32041-1723https://doaj.org/article/b0bd30f23bbe46f4ac1f69c4a193d1c12019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11983-3https://doaj.org/toc/2041-1723Na+-H+ exchanger 1 (Nhe1) regulates extracellular pH by extruding protons in exchange for extracellular Na+ . Here, Liu et al. show that Nhe1 promotes the development and acidification of atherosclerotic lesions and that pH-sensitive probes can be used to monitor plaque growth and acidification.Cong-Lin LiuXian ZhangJing LiuYunzhe WangGalina K. SukhovaGregory R. WojtkiewiczTianxiao LiuRui TangSamuel AchilefuMatthias NahrendorfPeter LibbyJunli GuoJin-Ying ZhangGuo-Ping ShiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
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DOAJ |
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EN |
topic |
Science Q |
spellingShingle |
Science Q Cong-Lin Liu Xian Zhang Jing Liu Yunzhe Wang Galina K. Sukhova Gregory R. Wojtkiewicz Tianxiao Liu Rui Tang Samuel Achilefu Matthias Nahrendorf Peter Libby Junli Guo Jin-Ying Zhang Guo-Ping Shi Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis |
description |
Na+-H+ exchanger 1 (Nhe1) regulates extracellular pH by extruding protons in exchange for extracellular Na+ . Here, Liu et al. show that Nhe1 promotes the development and acidification of atherosclerotic lesions and that pH-sensitive probes can be used to monitor plaque growth and acidification. |
format |
article |
author |
Cong-Lin Liu Xian Zhang Jing Liu Yunzhe Wang Galina K. Sukhova Gregory R. Wojtkiewicz Tianxiao Liu Rui Tang Samuel Achilefu Matthias Nahrendorf Peter Libby Junli Guo Jin-Ying Zhang Guo-Ping Shi |
author_facet |
Cong-Lin Liu Xian Zhang Jing Liu Yunzhe Wang Galina K. Sukhova Gregory R. Wojtkiewicz Tianxiao Liu Rui Tang Samuel Achilefu Matthias Nahrendorf Peter Libby Junli Guo Jin-Ying Zhang Guo-Ping Shi |
author_sort |
Cong-Lin Liu |
title |
Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis |
title_short |
Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis |
title_full |
Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis |
title_fullStr |
Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis |
title_full_unstemmed |
Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis |
title_sort |
na+-h+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/b0bd30f23bbe46f4ac1f69c4a193d1c1 |
work_keys_str_mv |
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