Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis

Na+-H+ exchanger 1 (Nhe1) regulates extracellular pH by extruding protons in exchange for extracellular Na+ . Here, Liu et al. show that Nhe1 promotes the development and acidification of atherosclerotic lesions and that pH-sensitive probes can be used to monitor plaque growth and acidification.

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Autores principales: Cong-Lin Liu, Xian Zhang, Jing Liu, Yunzhe Wang, Galina K. Sukhova, Gregory R. Wojtkiewicz, Tianxiao Liu, Rui Tang, Samuel Achilefu, Matthias Nahrendorf, Peter Libby, Junli Guo, Jin-Ying Zhang, Guo-Ping Shi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/b0bd30f23bbe46f4ac1f69c4a193d1c1
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spelling oai:doaj.org-article:b0bd30f23bbe46f4ac1f69c4a193d1c12021-12-02T16:57:45ZNa+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis10.1038/s41467-019-11983-32041-1723https://doaj.org/article/b0bd30f23bbe46f4ac1f69c4a193d1c12019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11983-3https://doaj.org/toc/2041-1723Na+-H+ exchanger 1 (Nhe1) regulates extracellular pH by extruding protons in exchange for extracellular Na+ . Here, Liu et al. show that Nhe1 promotes the development and acidification of atherosclerotic lesions and that pH-sensitive probes can be used to monitor plaque growth and acidification.Cong-Lin LiuXian ZhangJing LiuYunzhe WangGalina K. SukhovaGregory R. WojtkiewiczTianxiao LiuRui TangSamuel AchilefuMatthias NahrendorfPeter LibbyJunli GuoJin-Ying ZhangGuo-Ping ShiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Cong-Lin Liu
Xian Zhang
Jing Liu
Yunzhe Wang
Galina K. Sukhova
Gregory R. Wojtkiewicz
Tianxiao Liu
Rui Tang
Samuel Achilefu
Matthias Nahrendorf
Peter Libby
Junli Guo
Jin-Ying Zhang
Guo-Ping Shi
Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis
description Na+-H+ exchanger 1 (Nhe1) regulates extracellular pH by extruding protons in exchange for extracellular Na+ . Here, Liu et al. show that Nhe1 promotes the development and acidification of atherosclerotic lesions and that pH-sensitive probes can be used to monitor plaque growth and acidification.
format article
author Cong-Lin Liu
Xian Zhang
Jing Liu
Yunzhe Wang
Galina K. Sukhova
Gregory R. Wojtkiewicz
Tianxiao Liu
Rui Tang
Samuel Achilefu
Matthias Nahrendorf
Peter Libby
Junli Guo
Jin-Ying Zhang
Guo-Ping Shi
author_facet Cong-Lin Liu
Xian Zhang
Jing Liu
Yunzhe Wang
Galina K. Sukhova
Gregory R. Wojtkiewicz
Tianxiao Liu
Rui Tang
Samuel Achilefu
Matthias Nahrendorf
Peter Libby
Junli Guo
Jin-Ying Zhang
Guo-Ping Shi
author_sort Cong-Lin Liu
title Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis
title_short Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis
title_full Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis
title_fullStr Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis
title_full_unstemmed Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis
title_sort na+-h+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/b0bd30f23bbe46f4ac1f69c4a193d1c1
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