Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis

Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis

Na+-H+ exchanger 1 (Nhe1) regulates extracellular pH by extruding protons in exchange for extracellular Na+ . Here, Liu et al. show that Nhe1 promotes the development and acidification of atherosclerotic lesions and that pH-sensitive probes can be used to monitor plaque growth and acidification.

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Bibliographic Details
Main Authors: Cong-Lin Liu, Xian Zhang, Jing Liu, Yunzhe Wang, Galina K. Sukhova, Gregory R. Wojtkiewicz, Tianxiao Liu, Rui Tang, Samuel Achilefu, Matthias Nahrendorf, Peter Libby, Junli Guo, Jin-Ying Zhang, Guo-Ping Shi
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
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Online Access:https://doaj.org/article/b0bd30f23bbe46f4ac1f69c4a193d1c1
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https://doaj.org/article/b0bd30f23bbe46f4ac1f69c4a193d1c1

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