Cellular microRNA networks regulate host dependency of hepatitis C virus infection

Cellular microRNA networks regulate host dependency of hepatitis C virus infection

Using genome-wide miRNA mimic and hairpin inhibitor screens, Li et al. identify 31 miRNAs that either inhibit or promote hepatitis C virus (HCV) replication at different steps of the viral life cycle. Furthermore, human liver biopsies show that HCV down-regulates identified miRNAs with antiviral fun...

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Autores principales: Qisheng Li, Brianna Lowey, Catherine Sodroski, Siddharth Krishnamurthy, Hawwa Alao, Helen Cha, Stephan Chiu, Ramy El-Diwany, Marc G. Ghany, T. Jake Liang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/b0c163d7965544e795988bdc3ca37c83
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spelling oai:doaj.org-article:b0c163d7965544e795988bdc3ca37c832021-12-02T17:06:15ZCellular microRNA networks regulate host dependency of hepatitis C virus infection10.1038/s41467-017-01954-x2041-1723https://doaj.org/article/b0c163d7965544e795988bdc3ca37c832017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01954-xhttps://doaj.org/toc/2041-1723Using genome-wide miRNA mimic and hairpin inhibitor screens, Li et al. identify 31 miRNAs that either inhibit or promote hepatitis C virus (HCV) replication at different steps of the viral life cycle. Furthermore, human liver biopsies show that HCV down-regulates identified miRNAs with antiviral function.Qisheng LiBrianna LoweyCatherine SodroskiSiddharth KrishnamurthyHawwa AlaoHelen ChaStephan ChiuRamy El-DiwanyMarc G. GhanyT. Jake LiangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Qisheng Li
Brianna Lowey
Catherine Sodroski
Siddharth Krishnamurthy
Hawwa Alao
Helen Cha
Stephan Chiu
Ramy El-Diwany
Marc G. Ghany
T. Jake Liang
Cellular microRNA networks regulate host dependency of hepatitis C virus infection
description Using genome-wide miRNA mimic and hairpin inhibitor screens, Li et al. identify 31 miRNAs that either inhibit or promote hepatitis C virus (HCV) replication at different steps of the viral life cycle. Furthermore, human liver biopsies show that HCV down-regulates identified miRNAs with antiviral function.
format article
author Qisheng Li
Brianna Lowey
Catherine Sodroski
Siddharth Krishnamurthy
Hawwa Alao
Helen Cha
Stephan Chiu
Ramy El-Diwany
Marc G. Ghany
T. Jake Liang
author_facet Qisheng Li
Brianna Lowey
Catherine Sodroski
Siddharth Krishnamurthy
Hawwa Alao
Helen Cha
Stephan Chiu
Ramy El-Diwany
Marc G. Ghany
T. Jake Liang
author_sort Qisheng Li
title Cellular microRNA networks regulate host dependency of hepatitis C virus infection
title_short Cellular microRNA networks regulate host dependency of hepatitis C virus infection
title_full Cellular microRNA networks regulate host dependency of hepatitis C virus infection
title_fullStr Cellular microRNA networks regulate host dependency of hepatitis C virus infection
title_full_unstemmed Cellular microRNA networks regulate host dependency of hepatitis C virus infection
title_sort cellular microrna networks regulate host dependency of hepatitis c virus infection
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/b0c163d7965544e795988bdc3ca37c83
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AT catherinesodroski cellularmicrornanetworksregulatehostdependencyofhepatitiscvirusinfection
AT siddharthkrishnamurthy cellularmicrornanetworksregulatehostdependencyofhepatitiscvirusinfection
AT hawwaalao cellularmicrornanetworksregulatehostdependencyofhepatitiscvirusinfection
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AT ramyeldiwany cellularmicrornanetworksregulatehostdependencyofhepatitiscvirusinfection
AT marcgghany cellularmicrornanetworksregulatehostdependencyofhepatitiscvirusinfection
AT tjakeliang cellularmicrornanetworksregulatehostdependencyofhepatitiscvirusinfection
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