The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis
Abstract Background The ESR1 gene suffers methylation changes in many types of cancers, including breast cancer (BC), the most frequently diagnosed cancer in women that is also present in men. Methylation at promoter A of ESR1 is the worse prognosis in terms of overall survival; thus, the early dete...
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2021
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oai:doaj.org-article:b0c28489a619489d88c83795437c70bd2021-12-05T12:23:32ZThe high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis10.1186/s12935-021-02343-71475-2867https://doaj.org/article/b0c28489a619489d88c83795437c70bd2021-12-01T00:00:00Zhttps://doi.org/10.1186/s12935-021-02343-7https://doaj.org/toc/1475-2867Abstract Background The ESR1 gene suffers methylation changes in many types of cancers, including breast cancer (BC), the most frequently diagnosed cancer in women that is also present in men. Methylation at promoter A of ESR1 is the worse prognosis in terms of overall survival; thus, the early detection, prognostic, and prediction of therapy involve some methylation biomarkers. Methods Therefore, our study aimed to examine the methylation levels at the ESR1 gene in samples from Mexican BC patients and its possible association with menopausal status. Results We identified a novel 151-bp CpG island in the promoter A of the ESR1 gene. Interestingly, methylation levels at this CpG island in positive ERα tumors were approximately 50% less than negative ERα or control samples. Furthermore, methylation levels at ESR1 were associated with menopausal status. In postmenopausal patients, the methylation levels were 1.5-fold higher than in premenopausal patients. Finally, according to tumor malignancy, triple-negative cancer subtypes had higher ESR1 methylation levels than luminal/HER2+ or luminal A subtypes. Conclusions Our findings suggest that methylation at this novel CpG island might be a promising prognosis markerLaura Itzel Quintas-GranadosHernán CortésManuel González-Del CarmenGerardo Leyva-GómezLilia Patricia Bustamante-MontesMiguel Rodríguez-MoralesEdgar Yebran Villegas-VazquezIsrael López-ReyesSofía Lizeth Alcaraz-EstradaJorge Sandoval-BasilioErnesto Soto-ReyesJavad Sharifi-RadGabriela Figueroa-GonzálezOctavio Daniel Reyes-HernándezBMCarticleBreast cancerESR1 methylationMexican womenMenopausal stageNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282CytologyQH573-671ENCancer Cell International, Vol 21, Iss 1, Pp 1-11 (2021) |
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EN |
| topic |
Breast cancer ESR1 methylation Mexican women Menopausal stage Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671 |
| spellingShingle |
Breast cancer ESR1 methylation Mexican women Menopausal stage Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671 Laura Itzel Quintas-Granados Hernán Cortés Manuel González-Del Carmen Gerardo Leyva-Gómez Lilia Patricia Bustamante-Montes Miguel Rodríguez-Morales Edgar Yebran Villegas-Vazquez Israel López-Reyes Sofía Lizeth Alcaraz-Estrada Jorge Sandoval-Basilio Ernesto Soto-Reyes Javad Sharifi-Rad Gabriela Figueroa-González Octavio Daniel Reyes-Hernández The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis |
| description |
Abstract Background The ESR1 gene suffers methylation changes in many types of cancers, including breast cancer (BC), the most frequently diagnosed cancer in women that is also present in men. Methylation at promoter A of ESR1 is the worse prognosis in terms of overall survival; thus, the early detection, prognostic, and prediction of therapy involve some methylation biomarkers. Methods Therefore, our study aimed to examine the methylation levels at the ESR1 gene in samples from Mexican BC patients and its possible association with menopausal status. Results We identified a novel 151-bp CpG island in the promoter A of the ESR1 gene. Interestingly, methylation levels at this CpG island in positive ERα tumors were approximately 50% less than negative ERα or control samples. Furthermore, methylation levels at ESR1 were associated with menopausal status. In postmenopausal patients, the methylation levels were 1.5-fold higher than in premenopausal patients. Finally, according to tumor malignancy, triple-negative cancer subtypes had higher ESR1 methylation levels than luminal/HER2+ or luminal A subtypes. Conclusions Our findings suggest that methylation at this novel CpG island might be a promising prognosis marker |
| format |
article |
| author |
Laura Itzel Quintas-Granados Hernán Cortés Manuel González-Del Carmen Gerardo Leyva-Gómez Lilia Patricia Bustamante-Montes Miguel Rodríguez-Morales Edgar Yebran Villegas-Vazquez Israel López-Reyes Sofía Lizeth Alcaraz-Estrada Jorge Sandoval-Basilio Ernesto Soto-Reyes Javad Sharifi-Rad Gabriela Figueroa-González Octavio Daniel Reyes-Hernández |
| author_facet |
Laura Itzel Quintas-Granados Hernán Cortés Manuel González-Del Carmen Gerardo Leyva-Gómez Lilia Patricia Bustamante-Montes Miguel Rodríguez-Morales Edgar Yebran Villegas-Vazquez Israel López-Reyes Sofía Lizeth Alcaraz-Estrada Jorge Sandoval-Basilio Ernesto Soto-Reyes Javad Sharifi-Rad Gabriela Figueroa-González Octavio Daniel Reyes-Hernández |
| author_sort |
Laura Itzel Quintas-Granados |
| title |
The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis |
| title_short |
The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis |
| title_full |
The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis |
| title_fullStr |
The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis |
| title_full_unstemmed |
The high methylation level of a novel 151-bp CpG island in the ESR1 gene promoter is associated with a poor breast cancer prognosis |
| title_sort |
high methylation level of a novel 151-bp cpg island in the esr1 gene promoter is associated with a poor breast cancer prognosis |
| publisher |
BMC |
| publishDate |
2021 |
| url |
https://doaj.org/article/b0c28489a619489d88c83795437c70bd |
| work_keys_str_mv |
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