Full-thickness macular hole formation following anti-VEGF injections for neovascular age-related macular degeneration

Stamatina A Kabanarou,1 Tina Xirou,1 George Mangouritsas,1 Christina Garnavou-Xirou,2 Eirini Boutouri,1 Ilias Gkizis,1 Irini Chatziralli3 1Retina Department, Korgialeneio Benakeio, Hellenic Red Cross Hospital, Athens, Greece; 2Retina Department, King’s College Hospital, London, UK; 32nd D...

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Auteurs principaux:	Kabanarou SA, Xirou T, Mangouritsas G, Garnavou-Xirou C, Boutouri E, Gkizis I, Chatziralli I
Format:	article
Langue:	EN
Publié:	Dove Medical Press 2017
Sujets:	macular hole age-related macular degeneration anti-VEGF Geriatrics RC952-954.6
Accès en ligne:	https://doaj.org/article/b0c2ba974f164caab4917863750f3c98
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spelling	oai:doaj.org-article:b0c2ba974f164caab4917863750f3c982021-12-02T06:56:12ZFull-thickness macular hole formation following anti-VEGF injections for neovascular age-related macular degeneration1178-1998https://doaj.org/article/b0c2ba974f164caab4917863750f3c982017-05-01T00:00:00Zhttps://www.dovepress.com/full-thickness-macular-hole-formation-following-anti-vegf-injections-f-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Stamatina A Kabanarou,1 Tina Xirou,1 George Mangouritsas,1 Christina Garnavou-Xirou,2 Eirini Boutouri,1 Ilias Gkizis,1 Irini Chatziralli3 1Retina Department, Korgialeneio Benakeio, Hellenic Red Cross Hospital, Athens, Greece; 2Retina Department, King’s College Hospital, London, UK; 32nd Department of Ophthalmology, University of Athens, Athens, Greece Purpose: Macular hole (MH) is part of a group of age-related degenerative diseases characterized by pathology of vitreomacular interface. Similarly, neovascular age-related macular degeneration (nAMD) affects older patients and is a leading cause of irreversible visual loss. The purpose of this case series is to describe the development of full-thickness MH in patients with nAMD, following antivascular endothelial growth factor (anti-VEGF) treatment.Methods: Participants in this case series were four patients with nAMD, who received anti-VEGF injections with variable therapeutic response to treatment. Patients were examined at baseline (when AMD was diagnosed) and monthly thereafter. The examination included visual acuity measurement, slit-lamp biomicroscopy, and optical coherence tomography.Results: All patients were found to develop full-thickness MH within 1–4 months after the last anti-VEGF injection, even in the absence of pre-existing vitreomacular interface abnormalities in some cases. The median number of injections before the MH formation was 3.Conclusion: MH formation may represent an adverse effect of anti-VEGF treatment in patients with nAMD and could be also coexisting pathology with nAMD in older individuals. Keywords: macular hole, age-related macular degeneration, anti-VEGFKabanarou SAXirou TMangouritsas GGarnavou-Xirou CBoutouri EGkizis IChatziralli IDove Medical Pressarticlemacular holeage-related macular degenerationanti-VEGFGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 911-915 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	macular hole age-related macular degeneration anti-VEGF Geriatrics RC952-954.6
spellingShingle	macular hole age-related macular degeneration anti-VEGF Geriatrics RC952-954.6 Kabanarou SA Xirou T Mangouritsas G Garnavou-Xirou C Boutouri E Gkizis I Chatziralli I Full-thickness macular hole formation following anti-VEGF injections for neovascular age-related macular degeneration
description	Stamatina A Kabanarou,1 Tina Xirou,1 George Mangouritsas,1 Christina Garnavou-Xirou,2 Eirini Boutouri,1 Ilias Gkizis,1 Irini Chatziralli3 1Retina Department, Korgialeneio Benakeio, Hellenic Red Cross Hospital, Athens, Greece; 2Retina Department, King’s College Hospital, London, UK; 32nd Department of Ophthalmology, University of Athens, Athens, Greece Purpose: Macular hole (MH) is part of a group of age-related degenerative diseases characterized by pathology of vitreomacular interface. Similarly, neovascular age-related macular degeneration (nAMD) affects older patients and is a leading cause of irreversible visual loss. The purpose of this case series is to describe the development of full-thickness MH in patients with nAMD, following antivascular endothelial growth factor (anti-VEGF) treatment.Methods: Participants in this case series were four patients with nAMD, who received anti-VEGF injections with variable therapeutic response to treatment. Patients were examined at baseline (when AMD was diagnosed) and monthly thereafter. The examination included visual acuity measurement, slit-lamp biomicroscopy, and optical coherence tomography.Results: All patients were found to develop full-thickness MH within 1–4 months after the last anti-VEGF injection, even in the absence of pre-existing vitreomacular interface abnormalities in some cases. The median number of injections before the MH formation was 3.Conclusion: MH formation may represent an adverse effect of anti-VEGF treatment in patients with nAMD and could be also coexisting pathology with nAMD in older individuals. Keywords: macular hole, age-related macular degeneration, anti-VEGF
format	article
author	Kabanarou SA Xirou T Mangouritsas G Garnavou-Xirou C Boutouri E Gkizis I Chatziralli I
author_facet	Kabanarou SA Xirou T Mangouritsas G Garnavou-Xirou C Boutouri E Gkizis I Chatziralli I
author_sort	Kabanarou SA
title	Full-thickness macular hole formation following anti-VEGF injections for neovascular age-related macular degeneration
title_short	Full-thickness macular hole formation following anti-VEGF injections for neovascular age-related macular degeneration
title_full	Full-thickness macular hole formation following anti-VEGF injections for neovascular age-related macular degeneration
title_fullStr	Full-thickness macular hole formation following anti-VEGF injections for neovascular age-related macular degeneration
title_full_unstemmed	Full-thickness macular hole formation following anti-VEGF injections for neovascular age-related macular degeneration
title_sort	full-thickness macular hole formation following anti-vegf injections for neovascular age-related macular degeneration
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/b0c2ba974f164caab4917863750f3c98
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Full-thickness macular hole formation following anti-VEGF injections for neovascular age-related macular degeneration

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