Nanoparticle elasticity directs tumor uptake

Nanoparticle elasticity is thought to play an important role in drug delivery, but is little studied. Here, the authors use nanolipogels with tunable moduli to study the effect of particle elasticity on in vitro cellular uptake and in vivo tumor uptake, finding that stiffer particles are not as easi...

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Autores principales: Peng Guo, Daxing Liu, Kriti Subramanyam, Biran Wang, Jiang Yang, Jing Huang, Debra T. Auguste, Marsha A. Moses
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/b0c35e8e38be4608a71d8b47934d7d1f
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Sumario:Nanoparticle elasticity is thought to play an important role in drug delivery, but is little studied. Here, the authors use nanolipogels with tunable moduli to study the effect of particle elasticity on in vitro cellular uptake and in vivo tumor uptake, finding that stiffer particles are not as easily internalized.