Nanoparticle elasticity directs tumor uptake

Nanoparticle elasticity is thought to play an important role in drug delivery, but is little studied. Here, the authors use nanolipogels with tunable moduli to study the effect of particle elasticity on in vitro cellular uptake and in vivo tumor uptake, finding that stiffer particles are not as easi...

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Main Authors:	Peng Guo, Daxing Liu, Kriti Subramanyam, Biran Wang, Jiang Yang, Jing Huang, Debra T. Auguste, Marsha A. Moses
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/b0c35e8e38be4608a71d8b47934d7d1f
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spelling	oai:doaj.org-article:b0c35e8e38be4608a71d8b47934d7d1f2021-12-02T16:56:52ZNanoparticle elasticity directs tumor uptake10.1038/s41467-017-02588-92041-1723https://doaj.org/article/b0c35e8e38be4608a71d8b47934d7d1f2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02588-9https://doaj.org/toc/2041-1723Nanoparticle elasticity is thought to play an important role in drug delivery, but is little studied. Here, the authors use nanolipogels with tunable moduli to study the effect of particle elasticity on in vitro cellular uptake and in vivo tumor uptake, finding that stiffer particles are not as easily internalized.Peng GuoDaxing LiuKriti SubramanyamBiran WangJiang YangJing HuangDebra T. AugusteMarsha A. MosesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peng Guo Daxing Liu Kriti Subramanyam Biran Wang Jiang Yang Jing Huang Debra T. Auguste Marsha A. Moses Nanoparticle elasticity directs tumor uptake
description	Nanoparticle elasticity is thought to play an important role in drug delivery, but is little studied. Here, the authors use nanolipogels with tunable moduli to study the effect of particle elasticity on in vitro cellular uptake and in vivo tumor uptake, finding that stiffer particles are not as easily internalized.
format	article
author	Peng Guo Daxing Liu Kriti Subramanyam Biran Wang Jiang Yang Jing Huang Debra T. Auguste Marsha A. Moses
author_facet	Peng Guo Daxing Liu Kriti Subramanyam Biran Wang Jiang Yang Jing Huang Debra T. Auguste Marsha A. Moses
author_sort	Peng Guo
title	Nanoparticle elasticity directs tumor uptake
title_short	Nanoparticle elasticity directs tumor uptake
title_full	Nanoparticle elasticity directs tumor uptake
title_fullStr	Nanoparticle elasticity directs tumor uptake
title_full_unstemmed	Nanoparticle elasticity directs tumor uptake
title_sort	nanoparticle elasticity directs tumor uptake
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b0c35e8e38be4608a71d8b47934d7d1f
work_keys_str_mv	AT pengguo nanoparticleelasticitydirectstumoruptake AT daxingliu nanoparticleelasticitydirectstumoruptake AT kritisubramanyam nanoparticleelasticitydirectstumoruptake AT biranwang nanoparticleelasticitydirectstumoruptake AT jiangyang nanoparticleelasticitydirectstumoruptake AT jinghuang nanoparticleelasticitydirectstumoruptake AT debratauguste nanoparticleelasticitydirectstumoruptake AT marshaamoses nanoparticleelasticitydirectstumoruptake
_version_	1718382700075679744

Nanoparticle elasticity directs tumor uptake

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