Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus

Pamela KushnerUniversity of California, Irvine College of Medicine, California, USAAbstract: Hypoglycemia is a major barrier to achieving glycemic goals in patients with diabetes. Both acute and chronically recurrent hypoglycemic events appear to have long-term consequences for patients with type 2...

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Autor principal:	Pamela Kushner
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/b0c502d246c044ddaf6ada5c4b0b8245
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spelling	oai:doaj.org-article:b0c502d246c044ddaf6ada5c4b0b82452021-12-02T02:06:02ZMinimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus1178-7007https://doaj.org/article/b0c502d246c044ddaf6ada5c4b0b82452010-04-01T00:00:00Zhttp://www.dovepress.com/minimizing-the-risk-of-hypoglycemia-in-patients-with-type-2-diabetes-m-a4232https://doaj.org/toc/1178-7007Pamela KushnerUniversity of California, Irvine College of Medicine, California, USAAbstract: Hypoglycemia is a major barrier to achieving glycemic goals in patients with diabetes. Both acute and chronically recurrent hypoglycemic events appear to have long-term consequences for patients with type 2 diabetes mellitus (T2DM). Chronically recurrent hypoglycemia may lead to an impairment of the counterregulatory system, with the potential for the development of hypoglycemia unawareness syndrome, increased severe hypoglycemia-associated hospitalization, and increased mortality. Hypoglycemic events may also have negative implications in cardiovascular disease and/or dementia. Avoidance of hypoglycemia by treating with appropriate, individualized regimens for patients with T2DM should be a primary focus of physicians. Utilizing traditional agents (eg, metformin and thiazolidinediones) that do not promote hypoglycemia, in combination with newer agents such as dipeptidyl peptidase-4 inhibitors and incretin mimetics, could offer a therapeutic advantage when trying to help patients reach their hemoglobin A1c goal without the added risk of hypoglycemia.Keywords: hypoglycemia, type 2 diabetes mellitus, incretin, dipeptidyl peptidase-4 inhibitors, diabetes management Pamela KushnerDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2010, Iss default, Pp 49-53 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Pamela Kushner Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus
description	Pamela KushnerUniversity of California, Irvine College of Medicine, California, USAAbstract: Hypoglycemia is a major barrier to achieving glycemic goals in patients with diabetes. Both acute and chronically recurrent hypoglycemic events appear to have long-term consequences for patients with type 2 diabetes mellitus (T2DM). Chronically recurrent hypoglycemia may lead to an impairment of the counterregulatory system, with the potential for the development of hypoglycemia unawareness syndrome, increased severe hypoglycemia-associated hospitalization, and increased mortality. Hypoglycemic events may also have negative implications in cardiovascular disease and/or dementia. Avoidance of hypoglycemia by treating with appropriate, individualized regimens for patients with T2DM should be a primary focus of physicians. Utilizing traditional agents (eg, metformin and thiazolidinediones) that do not promote hypoglycemia, in combination with newer agents such as dipeptidyl peptidase-4 inhibitors and incretin mimetics, could offer a therapeutic advantage when trying to help patients reach their hemoglobin A1c goal without the added risk of hypoglycemia.Keywords: hypoglycemia, type 2 diabetes mellitus, incretin, dipeptidyl peptidase-4 inhibitors, diabetes management
format	article
author	Pamela Kushner
author_facet	Pamela Kushner
author_sort	Pamela Kushner
title	Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus
title_short	Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus
title_full	Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus
title_fullStr	Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus
title_full_unstemmed	Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus
title_sort	minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/b0c502d246c044ddaf6ada5c4b0b8245
work_keys_str_mv	AT pamelakushner minimizingtheriskofhypoglycemiainpatientswithtype2diabetesmellitus
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Minimizing the risk of hypoglycemia in patients with type 2 diabetes mellitus

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