Nano-scale delivery: A comprehensive review of nano-structured devices, preparative techniques, site-specificity designs, biomedical applications, commercial products, and references to safety, cellular uptake, and organ toxicity
This review focuses on nano-structured delivery devices prepared from biodegradable and biocompatible natural and synthetic polymers, organic raw materials, metals, metal oxides, and their other compounds that culminated in the preparation of various nano-entities depending on the preparative techni...
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De Gruyter
2021
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oai:doaj.org-article:b0c57556b19649e89e7c4f25878978872021-12-05T14:10:58ZNano-scale delivery: A comprehensive review of nano-structured devices, preparative techniques, site-specificity designs, biomedical applications, commercial products, and references to safety, cellular uptake, and organ toxicity2191-909710.1515/ntrev-2021-0096https://doaj.org/article/b0c57556b19649e89e7c4f25878978872021-10-01T00:00:00Zhttps://doi.org/10.1515/ntrev-2021-0096https://doaj.org/toc/2191-9097This review focuses on nano-structured delivery devices prepared from biodegradable and biocompatible natural and synthetic polymers, organic raw materials, metals, metal oxides, and their other compounds that culminated in the preparation of various nano-entities depending on the preparative techniques, and starting raw materials’ utilizations. Many nanoparticles (NPs) made of polymeric, metallic, magnetic, and non-magnetic origins, liposomes, hydrogels, dendrimers, and other carbon-based nano-entities have been produced. Developments in nanomaterial substrate and end products’ design, structural specifications, preparative strategies, chemo-biological interfacing to involve the biosystems interactions, surface functionalization, and on-site biomolecular and physiology-mediated target-specific delivery concepts, examples, and applications are outlined. The inherent toxicity, and safety of the design concepts in nanomaterial preparation, and their applications in biomedical fields, especially to the organs, cellular and sub-cellular deliveries are deliberated. Bioapplications, the therapeutic delivery modules’ pharmacokinetics and medicinal values, nanopharmaceutical designs, and their contributions as nano-entities in the healthcare biotechnology of drug delivery domains have also been discussed. The importance of site-specific triggers in nano-scale deliveries, the inherent and induced structural specifications of numerous nanomaterial entities belonging to NPs, nano-scale composites, nano-conjugates, and other nano-devices of organic and inorganic origins, near biological systems are detailed. Modifications that provide nano-deliveries of their intrinsic therapeutic actions, through structural and physicochemical characteristics modifications, and the proven success of various nano-delivery devices and currently available commercial nanomedicinal and nanopharmaceutical products are also provided.Abdellatif Ahmed A. H.Mohammed Hamdoon A.Khan Riaz A.Singh VarshaBouazzaoui AbdellatifYusuf MohammadAkhtar NaseemKhan MariaAl-Subaiyel AmalMohammed Salman A. A.Al-Omar Mohsen S.De Gruyterarticlenanomedicinenanoparticleshydrogelsliposomesdendrimerscarbon nanotubesdrug deliverybiomedical applicationsnano-productstoxicityTechnologyTChemical technologyTP1-1185Physical and theoretical chemistryQD450-801ENNanotechnology Reviews, Vol 10, Iss 1, Pp 1493-1559 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
nanomedicine nanoparticles hydrogels liposomes dendrimers carbon nanotubes drug delivery biomedical applications nano-products toxicity Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801 |
| spellingShingle |
nanomedicine nanoparticles hydrogels liposomes dendrimers carbon nanotubes drug delivery biomedical applications nano-products toxicity Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801 Abdellatif Ahmed A. H. Mohammed Hamdoon A. Khan Riaz A. Singh Varsha Bouazzaoui Abdellatif Yusuf Mohammad Akhtar Naseem Khan Maria Al-Subaiyel Amal Mohammed Salman A. A. Al-Omar Mohsen S. Nano-scale delivery: A comprehensive review of nano-structured devices, preparative techniques, site-specificity designs, biomedical applications, commercial products, and references to safety, cellular uptake, and organ toxicity |
| description |
This review focuses on nano-structured delivery devices prepared from biodegradable and biocompatible natural and synthetic polymers, organic raw materials, metals, metal oxides, and their other compounds that culminated in the preparation of various nano-entities depending on the preparative techniques, and starting raw materials’ utilizations. Many nanoparticles (NPs) made of polymeric, metallic, magnetic, and non-magnetic origins, liposomes, hydrogels, dendrimers, and other carbon-based nano-entities have been produced. Developments in nanomaterial substrate and end products’ design, structural specifications, preparative strategies, chemo-biological interfacing to involve the biosystems interactions, surface functionalization, and on-site biomolecular and physiology-mediated target-specific delivery concepts, examples, and applications are outlined. The inherent toxicity, and safety of the design concepts in nanomaterial preparation, and their applications in biomedical fields, especially to the organs, cellular and sub-cellular deliveries are deliberated. Bioapplications, the therapeutic delivery modules’ pharmacokinetics and medicinal values, nanopharmaceutical designs, and their contributions as nano-entities in the healthcare biotechnology of drug delivery domains have also been discussed. The importance of site-specific triggers in nano-scale deliveries, the inherent and induced structural specifications of numerous nanomaterial entities belonging to NPs, nano-scale composites, nano-conjugates, and other nano-devices of organic and inorganic origins, near biological systems are detailed. Modifications that provide nano-deliveries of their intrinsic therapeutic actions, through structural and physicochemical characteristics modifications, and the proven success of various nano-delivery devices and currently available commercial nanomedicinal and nanopharmaceutical products are also provided. |
| format |
article |
| author |
Abdellatif Ahmed A. H. Mohammed Hamdoon A. Khan Riaz A. Singh Varsha Bouazzaoui Abdellatif Yusuf Mohammad Akhtar Naseem Khan Maria Al-Subaiyel Amal Mohammed Salman A. A. Al-Omar Mohsen S. |
| author_facet |
Abdellatif Ahmed A. H. Mohammed Hamdoon A. Khan Riaz A. Singh Varsha Bouazzaoui Abdellatif Yusuf Mohammad Akhtar Naseem Khan Maria Al-Subaiyel Amal Mohammed Salman A. A. Al-Omar Mohsen S. |
| author_sort |
Abdellatif Ahmed A. H. |
| title |
Nano-scale delivery: A comprehensive review of nano-structured devices, preparative techniques, site-specificity designs, biomedical applications, commercial products, and references to safety, cellular uptake, and organ toxicity |
| title_short |
Nano-scale delivery: A comprehensive review of nano-structured devices, preparative techniques, site-specificity designs, biomedical applications, commercial products, and references to safety, cellular uptake, and organ toxicity |
| title_full |
Nano-scale delivery: A comprehensive review of nano-structured devices, preparative techniques, site-specificity designs, biomedical applications, commercial products, and references to safety, cellular uptake, and organ toxicity |
| title_fullStr |
Nano-scale delivery: A comprehensive review of nano-structured devices, preparative techniques, site-specificity designs, biomedical applications, commercial products, and references to safety, cellular uptake, and organ toxicity |
| title_full_unstemmed |
Nano-scale delivery: A comprehensive review of nano-structured devices, preparative techniques, site-specificity designs, biomedical applications, commercial products, and references to safety, cellular uptake, and organ toxicity |
| title_sort |
nano-scale delivery: a comprehensive review of nano-structured devices, preparative techniques, site-specificity designs, biomedical applications, commercial products, and references to safety, cellular uptake, and organ toxicity |
| publisher |
De Gruyter |
| publishDate |
2021 |
| url |
https://doaj.org/article/b0c57556b19649e89e7c4f2587897887 |
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