Experimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque

It is hypothesised that exposure to bovine spongiform encephalopathy through contaminated food could have resulted in a large proportion of latent variant Creutzfeldt-Jakob disease cases in humans. Here the authors demonstrate that inoculation with blood from non-symptomatic, vCJD infected humans, r...

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Auteurs principaux:	Emmanuel E. Comoy, Jacqueline Mikol, Nina Jaffré, Vincent Lebon, Etienne Levavasseur, Nathalie Streichenberger, Chryslain Sumian, Armand Perret-Liaudet, Marc Eloit, Olivier Andreoletti, Stéphane Haïk, Philippe Hantraye, Jean-Philippe Deslys
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/b0c9168d37d3407aa90721d13daa5b6c
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spelling	oai:doaj.org-article:b0c9168d37d3407aa90721d13daa5b6c2021-12-02T17:06:25ZExperimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque10.1038/s41467-017-01347-02041-1723https://doaj.org/article/b0c9168d37d3407aa90721d13daa5b6c2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01347-0https://doaj.org/toc/2041-1723It is hypothesised that exposure to bovine spongiform encephalopathy through contaminated food could have resulted in a large proportion of latent variant Creutzfeldt-Jakob disease cases in humans. Here the authors demonstrate that inoculation with blood from non-symptomatic, vCJD infected humans, results in a unique prion-like disorder in mice and macaques.Emmanuel E. ComoyJacqueline MikolNina JaffréVincent LebonEtienne LevavasseurNathalie StreichenbergerChryslain SumianArmand Perret-LiaudetMarc EloitOlivier AndreolettiStéphane HaïkPhilippe HantrayeJean-Philippe DeslysNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emmanuel E. Comoy Jacqueline Mikol Nina Jaffré Vincent Lebon Etienne Levavasseur Nathalie Streichenberger Chryslain Sumian Armand Perret-Liaudet Marc Eloit Olivier Andreoletti Stéphane Haïk Philippe Hantraye Jean-Philippe Deslys Experimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque
description	It is hypothesised that exposure to bovine spongiform encephalopathy through contaminated food could have resulted in a large proportion of latent variant Creutzfeldt-Jakob disease cases in humans. Here the authors demonstrate that inoculation with blood from non-symptomatic, vCJD infected humans, results in a unique prion-like disorder in mice and macaques.
format	article
author	Emmanuel E. Comoy Jacqueline Mikol Nina Jaffré Vincent Lebon Etienne Levavasseur Nathalie Streichenberger Chryslain Sumian Armand Perret-Liaudet Marc Eloit Olivier Andreoletti Stéphane Haïk Philippe Hantraye Jean-Philippe Deslys
author_facet	Emmanuel E. Comoy Jacqueline Mikol Nina Jaffré Vincent Lebon Etienne Levavasseur Nathalie Streichenberger Chryslain Sumian Armand Perret-Liaudet Marc Eloit Olivier Andreoletti Stéphane Haïk Philippe Hantraye Jean-Philippe Deslys
author_sort	Emmanuel E. Comoy
title	Experimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque
title_short	Experimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque
title_full	Experimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque
title_fullStr	Experimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque
title_full_unstemmed	Experimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque
title_sort	experimental transfusion of variant cjd-infected blood reveals previously uncharacterised prion disorder in mice and macaque
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b0c9168d37d3407aa90721d13daa5b6c
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Experimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque

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