IgG1 memory B cells keep the memory of IgE responses

IgE is an important mediator of protective immunity as well as allergic reaction, but how high affinity IgE antibodies are produced in memory responses is not clear. Here the authors show that IgE can be generated via class-switch recombination in IgG1 memory B cells without additional somatic hyper...

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Autores principales:	Jin-Shu He, Sharrada Subramaniam, Vipin Narang, Kandhadayar Srinivasan, Sean P. Saunders, Daniel Carbajo, Tsao Wen-Shan, Nur Hidayah Hamadee, Josephine Lum, Andrea Lee, Jinmiao Chen, Michael Poidinger, Francesca Zolezzi, Juan J. Lafaille, Maria A. Curotto de Lafaille
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b0cb1457667e4bd2866daf4adcb12580
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spelling	oai:doaj.org-article:b0cb1457667e4bd2866daf4adcb125802021-12-02T14:40:23ZIgG1 memory B cells keep the memory of IgE responses10.1038/s41467-017-00723-02041-1723https://doaj.org/article/b0cb1457667e4bd2866daf4adcb125802017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00723-0https://doaj.org/toc/2041-1723IgE is an important mediator of protective immunity as well as allergic reaction, but how high affinity IgE antibodies are produced in memory responses is not clear. Here the authors show that IgE can be generated via class-switch recombination in IgG1 memory B cells without additional somatic hypermutation.Jin-Shu HeSharrada SubramaniamVipin NarangKandhadayar SrinivasanSean P. SaundersDaniel CarbajoTsao Wen-ShanNur Hidayah HamadeeJosephine LumAndrea LeeJinmiao ChenMichael PoidingerFrancesca ZolezziJuan J. LafailleMaria A. Curotto de LafailleNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jin-Shu He Sharrada Subramaniam Vipin Narang Kandhadayar Srinivasan Sean P. Saunders Daniel Carbajo Tsao Wen-Shan Nur Hidayah Hamadee Josephine Lum Andrea Lee Jinmiao Chen Michael Poidinger Francesca Zolezzi Juan J. Lafaille Maria A. Curotto de Lafaille IgG1 memory B cells keep the memory of IgE responses
description	IgE is an important mediator of protective immunity as well as allergic reaction, but how high affinity IgE antibodies are produced in memory responses is not clear. Here the authors show that IgE can be generated via class-switch recombination in IgG1 memory B cells without additional somatic hypermutation.
format	article
author	Jin-Shu He Sharrada Subramaniam Vipin Narang Kandhadayar Srinivasan Sean P. Saunders Daniel Carbajo Tsao Wen-Shan Nur Hidayah Hamadee Josephine Lum Andrea Lee Jinmiao Chen Michael Poidinger Francesca Zolezzi Juan J. Lafaille Maria A. Curotto de Lafaille
author_facet	Jin-Shu He Sharrada Subramaniam Vipin Narang Kandhadayar Srinivasan Sean P. Saunders Daniel Carbajo Tsao Wen-Shan Nur Hidayah Hamadee Josephine Lum Andrea Lee Jinmiao Chen Michael Poidinger Francesca Zolezzi Juan J. Lafaille Maria A. Curotto de Lafaille
author_sort	Jin-Shu He
title	IgG1 memory B cells keep the memory of IgE responses
title_short	IgG1 memory B cells keep the memory of IgE responses
title_full	IgG1 memory B cells keep the memory of IgE responses
title_fullStr	IgG1 memory B cells keep the memory of IgE responses
title_full_unstemmed	IgG1 memory B cells keep the memory of IgE responses
title_sort	igg1 memory b cells keep the memory of ige responses
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b0cb1457667e4bd2866daf4adcb12580
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IgG1 memory B cells keep the memory of IgE responses

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