Genetic programming of macrophages generates an in vitro model for the human erythroid island niche

In vitro differentiation of red blood cells (RBCs) is a desirable therapy for various disorders. Here the authors develop a culture system using stem cell-derived macrophages to show that inducible expression of a transcription factor, KLF1, enhances RBC production, potentially through the induction...

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Autores principales:	Martha Lopez-Yrigoyen, Cheng-Tao Yang, Antonella Fidanza, Luca Cassetta, A. Helen Taylor, Angela McCahill, Erica Sellink, Marieke von Lindern, Emile van den Akker, Joanne C. Mountford, Jeffrey W. Pollard, Lesley M. Forrester
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b0cccdc9bb284487980ca46db3249dc4
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spelling	oai:doaj.org-article:b0cccdc9bb284487980ca46db3249dc42021-12-02T17:01:58ZGenetic programming of macrophages generates an in vitro model for the human erythroid island niche10.1038/s41467-019-08705-02041-1723https://doaj.org/article/b0cccdc9bb284487980ca46db3249dc42019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08705-0https://doaj.org/toc/2041-1723In vitro differentiation of red blood cells (RBCs) is a desirable therapy for various disorders. Here the authors develop a culture system using stem cell-derived macrophages to show that inducible expression of a transcription factor, KLF1, enhances RBC production, potentially through the induction of three soluble factors, ANGPTL7, IL33 and SERPINB2.Martha Lopez-YrigoyenCheng-Tao YangAntonella FidanzaLuca CassettaA. Helen TaylorAngela McCahillErica SellinkMarieke von LindernEmile van den AkkerJoanne C. MountfordJeffrey W. PollardLesley M. ForresterNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martha Lopez-Yrigoyen Cheng-Tao Yang Antonella Fidanza Luca Cassetta A. Helen Taylor Angela McCahill Erica Sellink Marieke von Lindern Emile van den Akker Joanne C. Mountford Jeffrey W. Pollard Lesley M. Forrester Genetic programming of macrophages generates an in vitro model for the human erythroid island niche
description	In vitro differentiation of red blood cells (RBCs) is a desirable therapy for various disorders. Here the authors develop a culture system using stem cell-derived macrophages to show that inducible expression of a transcription factor, KLF1, enhances RBC production, potentially through the induction of three soluble factors, ANGPTL7, IL33 and SERPINB2.
format	article
author	Martha Lopez-Yrigoyen Cheng-Tao Yang Antonella Fidanza Luca Cassetta A. Helen Taylor Angela McCahill Erica Sellink Marieke von Lindern Emile van den Akker Joanne C. Mountford Jeffrey W. Pollard Lesley M. Forrester
author_facet	Martha Lopez-Yrigoyen Cheng-Tao Yang Antonella Fidanza Luca Cassetta A. Helen Taylor Angela McCahill Erica Sellink Marieke von Lindern Emile van den Akker Joanne C. Mountford Jeffrey W. Pollard Lesley M. Forrester
author_sort	Martha Lopez-Yrigoyen
title	Genetic programming of macrophages generates an in vitro model for the human erythroid island niche
title_short	Genetic programming of macrophages generates an in vitro model for the human erythroid island niche
title_full	Genetic programming of macrophages generates an in vitro model for the human erythroid island niche
title_fullStr	Genetic programming of macrophages generates an in vitro model for the human erythroid island niche
title_full_unstemmed	Genetic programming of macrophages generates an in vitro model for the human erythroid island niche
title_sort	genetic programming of macrophages generates an in vitro model for the human erythroid island niche
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b0cccdc9bb284487980ca46db3249dc4
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Genetic programming of macrophages generates an in vitro model for the human erythroid island niche

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