Genetic programming of macrophages generates an in vitro model for the human erythroid island niche

In vitro differentiation of red blood cells (RBCs) is a desirable therapy for various disorders. Here the authors develop a culture system using stem cell-derived macrophages to show that inducible expression of a transcription factor, KLF1, enhances RBC production, potentially through the induction...

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Autores principales: Martha Lopez-Yrigoyen, Cheng-Tao Yang, Antonella Fidanza, Luca Cassetta, A. Helen Taylor, Angela McCahill, Erica Sellink, Marieke von Lindern, Emile van den Akker, Joanne C. Mountford, Jeffrey W. Pollard, Lesley M. Forrester
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/b0cccdc9bb284487980ca46db3249dc4
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