Nongenotoxic ABCB1 activator tetraphenylphosphonium can contribute to doxorubicin resistance in MX-1 breast cancer cell line

Nongenotoxic ABCB1 activator tetraphenylphosphonium can contribute to doxorubicin resistance in MX-1 breast cancer cell line

Abstract Hyperactivation of ABC transporter ABCB1 and induction of epithelial–mesenchymal transition (EMT) are the most common mechanism of acquired cancer chemoresistance. This study describes possible mechanisms, that might contribute to upregulation of ABCB1 and synergistically boost the acquisit...

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Autores principales: Raimonda Kubiliute, Indre Januskeviciene, Ruta Urbanaviciute, Kristina Daniunaite, Monika Drobniene, Valerijus Ostapenko, Rimantas Daugelavicius, Sonata Jarmalaite
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/b0cfe9885eb14543aa4eed855fbd4b5b
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