Prognostic Value of LC3B and p62 Expression in Small Intestinal Adenocarcinoma

Autophagy, a mechanism that maintains cellular homeostasis, is involved in tumor cell growth and survival in cancer, and autophagy inhibitors have been tested clinical trials for anticancer therapy. To elucidate the clinical and prognostic implications of autophagy in small intestinal adenocarcinoma...

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Autores principales:	Jeong-Won Kim, Sun-Young Jun, Joon-Mee Kim, Young-Ha Oh, Ghilsuk Yoon, Seung-Mo Hong, Joon-Yong Chung
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	LC3B p62 prognosis small intestine adenocarcinoma Medicine R
Acceso en línea:	https://doaj.org/article/b0d68ac59f1b4547ab81bf874a9d824f
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spelling	oai:doaj.org-article:b0d68ac59f1b4547ab81bf874a9d824f2021-11-25T18:02:25ZPrognostic Value of LC3B and p62 Expression in Small Intestinal Adenocarcinoma10.3390/jcm102253982077-0383https://doaj.org/article/b0d68ac59f1b4547ab81bf874a9d824f2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5398https://doaj.org/toc/2077-0383Autophagy, a mechanism that maintains cellular homeostasis, is involved in tumor cell growth and survival in cancer, and autophagy inhibitors have been tested clinical trials for anticancer therapy. To elucidate the clinical and prognostic implications of autophagy in small intestinal adenocarcinoma (SIAC), we assessed the expression of autophagy markers, LC3B and p62, in 171 surgically resected primary SIACs using automated quantitative analysis. Positive LC3B, p62 nuclear (p62<sup>Nu</sup>), and p62 cytoplasmic (p62<sup>Cy</sup>) expression was observed in 23 (13.5%), 52 (30.4%), and 43 (25.1%) carcinomas, respectively. LC3B+ expression was correlated with undifferentiated carcinoma (<i>p</i> < 0.001) and high histologic grade (<i>p</i> = 0.029). The combined expression of LC3B and p62<sup>Nu</sup> (LC3+/p62<sup>Nu</sup>+) was related to the older age of patients (<i>p</i> = 0.017), undifferentiated carcinoma (<i>p</i> < 0.001), and high grade (<i>p</i> = 0.031). LC3B+ (<i>p</i> = 0.006), p62<sup>Cy</sup>+ (<i>p</i> = 0.041), or p62<sup>Nu</sup>+ (<i>p</i> = 0.006) expression were associated with worse survival. In addition, SIAC patients with either LC3B+/p62<sup>Nu</sup>+ (<i>p</i> = 0.001) or LC3B+/p62<sup>Cy</sup>+ (<i>p</i> = 0.002) expression had shorter survival times. In multivariate analysis, LC3B expression remained an independent prognostic factor (<i>p</i> = 0.025) for overall survival. In conclusion, autophagy may play a role in the tumorigenesis of SIACs, and LC3B and p62 could be used as prognostic biomarkers and potential therapeutic targets for SIACs.Jeong-Won KimSun-Young JunJoon-Mee KimYoung-Ha OhGhilsuk YoonSeung-Mo HongJoon-Yong ChungMDPI AGarticleLC3Bp62prognosissmall intestineadenocarcinomaMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5398, p 5398 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	LC3B p62 prognosis small intestine adenocarcinoma Medicine R
spellingShingle	LC3B p62 prognosis small intestine adenocarcinoma Medicine R Jeong-Won Kim Sun-Young Jun Joon-Mee Kim Young-Ha Oh Ghilsuk Yoon Seung-Mo Hong Joon-Yong Chung Prognostic Value of LC3B and p62 Expression in Small Intestinal Adenocarcinoma
description	Autophagy, a mechanism that maintains cellular homeostasis, is involved in tumor cell growth and survival in cancer, and autophagy inhibitors have been tested clinical trials for anticancer therapy. To elucidate the clinical and prognostic implications of autophagy in small intestinal adenocarcinoma (SIAC), we assessed the expression of autophagy markers, LC3B and p62, in 171 surgically resected primary SIACs using automated quantitative analysis. Positive LC3B, p62 nuclear (p62<sup>Nu</sup>), and p62 cytoplasmic (p62<sup>Cy</sup>) expression was observed in 23 (13.5%), 52 (30.4%), and 43 (25.1%) carcinomas, respectively. LC3B+ expression was correlated with undifferentiated carcinoma (<i>p</i> < 0.001) and high histologic grade (<i>p</i> = 0.029). The combined expression of LC3B and p62<sup>Nu</sup> (LC3+/p62<sup>Nu</sup>+) was related to the older age of patients (<i>p</i> = 0.017), undifferentiated carcinoma (<i>p</i> < 0.001), and high grade (<i>p</i> = 0.031). LC3B+ (<i>p</i> = 0.006), p62<sup>Cy</sup>+ (<i>p</i> = 0.041), or p62<sup>Nu</sup>+ (<i>p</i> = 0.006) expression were associated with worse survival. In addition, SIAC patients with either LC3B+/p62<sup>Nu</sup>+ (<i>p</i> = 0.001) or LC3B+/p62<sup>Cy</sup>+ (<i>p</i> = 0.002) expression had shorter survival times. In multivariate analysis, LC3B expression remained an independent prognostic factor (<i>p</i> = 0.025) for overall survival. In conclusion, autophagy may play a role in the tumorigenesis of SIACs, and LC3B and p62 could be used as prognostic biomarkers and potential therapeutic targets for SIACs.
format	article
author	Jeong-Won Kim Sun-Young Jun Joon-Mee Kim Young-Ha Oh Ghilsuk Yoon Seung-Mo Hong Joon-Yong Chung
author_facet	Jeong-Won Kim Sun-Young Jun Joon-Mee Kim Young-Ha Oh Ghilsuk Yoon Seung-Mo Hong Joon-Yong Chung
author_sort	Jeong-Won Kim
title	Prognostic Value of LC3B and p62 Expression in Small Intestinal Adenocarcinoma
title_short	Prognostic Value of LC3B and p62 Expression in Small Intestinal Adenocarcinoma
title_full	Prognostic Value of LC3B and p62 Expression in Small Intestinal Adenocarcinoma
title_fullStr	Prognostic Value of LC3B and p62 Expression in Small Intestinal Adenocarcinoma
title_full_unstemmed	Prognostic Value of LC3B and p62 Expression in Small Intestinal Adenocarcinoma
title_sort	prognostic value of lc3b and p62 expression in small intestinal adenocarcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b0d68ac59f1b4547ab81bf874a9d824f
work_keys_str_mv	AT jeongwonkim prognosticvalueoflc3bandp62expressioninsmallintestinaladenocarcinoma AT sunyoungjun prognosticvalueoflc3bandp62expressioninsmallintestinaladenocarcinoma AT joonmeekim prognosticvalueoflc3bandp62expressioninsmallintestinaladenocarcinoma AT younghaoh prognosticvalueoflc3bandp62expressioninsmallintestinaladenocarcinoma AT ghilsukyoon prognosticvalueoflc3bandp62expressioninsmallintestinaladenocarcinoma AT seungmohong prognosticvalueoflc3bandp62expressioninsmallintestinaladenocarcinoma AT joonyongchung prognosticvalueoflc3bandp62expressioninsmallintestinaladenocarcinoma
_version_	1718411702017458176

Prognostic Value of LC3B and p62 Expression in Small Intestinal Adenocarcinoma

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