Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus

Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus

Lysocin E is a lipopeptide with antibiotic activity against methicillin-resistant Staphylococcus aureus. Here, the authors show that the antimicrobial activity of lysocin E is potentiated through interactions with host serum proteins (such as apolipoprotein A-I) and bacterial membrane components.

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Autores principales: Hiroshi Hamamoto, Suresh Panthee, Atmika Paudel, Kenichi Ishii, Jyunichiro Yasukawa, Jie Su, Atsushi Miyashita, Hiroaki Itoh, Kotaro Tokumoto, Masayuki Inoue, Kazuhisa Sekimizu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b0d96c9f5e974962964e3a02e7b2c23b
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spelling oai:doaj.org-article:b0d96c9f5e974962964e3a02e7b2c23b2021-11-08T11:06:35ZSerum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus10.1038/s41467-021-26702-02041-1723https://doaj.org/article/b0d96c9f5e974962964e3a02e7b2c23b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26702-0https://doaj.org/toc/2041-1723Lysocin E is a lipopeptide with antibiotic activity against methicillin-resistant Staphylococcus aureus. Here, the authors show that the antimicrobial activity of lysocin E is potentiated through interactions with host serum proteins (such as apolipoprotein A-I) and bacterial membrane components.Hiroshi HamamotoSuresh PantheeAtmika PaudelKenichi IshiiJyunichiro YasukawaJie SuAtsushi MiyashitaHiroaki ItohKotaro TokumotoMasayuki InoueKazuhisa SekimizuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hiroshi Hamamoto
Suresh Panthee
Atmika Paudel
Kenichi Ishii
Jyunichiro Yasukawa
Jie Su
Atsushi Miyashita
Hiroaki Itoh
Kotaro Tokumoto
Masayuki Inoue
Kazuhisa Sekimizu
Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus
description Lysocin E is a lipopeptide with antibiotic activity against methicillin-resistant Staphylococcus aureus. Here, the authors show that the antimicrobial activity of lysocin E is potentiated through interactions with host serum proteins (such as apolipoprotein A-I) and bacterial membrane components.
format article
author Hiroshi Hamamoto
Suresh Panthee
Atmika Paudel
Kenichi Ishii
Jyunichiro Yasukawa
Jie Su
Atsushi Miyashita
Hiroaki Itoh
Kotaro Tokumoto
Masayuki Inoue
Kazuhisa Sekimizu
author_facet Hiroshi Hamamoto
Suresh Panthee
Atmika Paudel
Kenichi Ishii
Jyunichiro Yasukawa
Jie Su
Atsushi Miyashita
Hiroaki Itoh
Kotaro Tokumoto
Masayuki Inoue
Kazuhisa Sekimizu
author_sort Hiroshi Hamamoto
title Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus
title_short Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus
title_full Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus
title_fullStr Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus
title_full_unstemmed Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus
title_sort serum apolipoprotein a-i potentiates the therapeutic efficacy of lysocin e against staphylococcus aureus
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/b0d96c9f5e974962964e3a02e7b2c23b
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