Comparison of urinary KIM-1 and NGAL and plasma creatinine in patients undergoing coronary artery bypass graft surgery

Introduction: Serum creatinine level is currently being used as an indicator to detect acute kidney injury (AKI) after cardiac surgery, which is delayed and unreliable. Objectives: This study was conducted to determine the AKI in patients undergoing coronary artery bypass graft (CABG) surgery by mea...

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Autores principales: Maryam Saeedi Ghaheh, Saeed Mardani, Afsaneh Malekpour, Farzaneh Kadkhodaei Elyaderani, Fatemeh Salehi Choliche, Nayereh Mortazavi, Shadi Botshekan
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Publicado: Society of Diabetic Nephropathy Prevention 2021
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Acceso en línea:https://doaj.org/article/b0dcee415ff94a1cb44f140c8aaedc31
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spelling oai:doaj.org-article:b0dcee415ff94a1cb44f140c8aaedc312021-11-17T08:13:57ZComparison of urinary KIM-1 and NGAL and plasma creatinine in patients undergoing coronary artery bypass graft surgery2345-420210.34172/npj.2021.04https://doaj.org/article/b0dcee415ff94a1cb44f140c8aaedc312021-01-01T00:00:00Zhttps://jnephropharmacology.com/PDF/npj-10324https://doaj.org/toc/2345-4202Introduction: Serum creatinine level is currently being used as an indicator to detect acute kidney injury (AKI) after cardiac surgery, which is delayed and unreliable. Objectives: This study was conducted to determine the AKI in patients undergoing coronary artery bypass graft (CABG) surgery by measurement of urinary creatinine and plasma kidney injury molecule (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL). Patients and Methods: In this cross-sectional study, 96 patients undergoing CABG were divided based on their serum creatinine level of the fourth day after procedure into two groups of AKI (an increase of creatinine more than 0.3 mg/dl or more than 150 % of its baseline level) and non-AKI. In both groups urinary KIM-1 and urinary NGAL were measured on the first day of surgery (first 24 h). Results: No significant difference was observed in baseline creatinine between the two groups (P>0.05). However postoperative serum creatinine, creatinine changes, urinary NGAL and KIM1 showed significant difference between the groups (P<0.05). Serum creatinine was positively correlated with KIM-1 (r = 0.666, P<0.001) and NGAL (r = 0.660, P<0.001). KIM-1 and NGAL had high ability to detect AKI [area under the ROC (receiver operating characteristic) curve of 0.929 and 0.838, respectively]. The NGAL at cut-off point of 97.4 had 86% sensitivity and 80% specificity and KIM-1 at cut-off point of 14.8 had 84% sensitivity and 89% specificity. Conclusion: KIM-1 and NGAL had high ability to detect AKI. However, KIM-1 had higher detection ability than that of NGAL.Maryam Saeedi GhahehSaeed MardaniAfsaneh MalekpourFarzaneh Kadkhodaei ElyaderaniFatemeh Salehi CholicheNayereh MortazaviShadi BotshekanSociety of Diabetic Nephropathy Prevention articleneutrophil gelatinase-associated lipocalin (ngal)acute renal injurycoronary artery bypass graft surgerykidney injury molecule (kim-1)Therapeutics. PharmacologyRM1-950Diseases of the genitourinary system. UrologyRC870-923ENJournal of Nephropharmacology, Vol 10, Iss 1, Pp e04-e04 (2021)
institution DOAJ
collection DOAJ
language EN
topic neutrophil gelatinase-associated lipocalin (ngal)
acute renal injury
coronary artery bypass graft surgery
kidney injury molecule (kim-1)
Therapeutics. Pharmacology
RM1-950
Diseases of the genitourinary system. Urology
RC870-923
spellingShingle neutrophil gelatinase-associated lipocalin (ngal)
acute renal injury
coronary artery bypass graft surgery
kidney injury molecule (kim-1)
Therapeutics. Pharmacology
RM1-950
Diseases of the genitourinary system. Urology
RC870-923
Maryam Saeedi Ghaheh
Saeed Mardani
Afsaneh Malekpour
Farzaneh Kadkhodaei Elyaderani
Fatemeh Salehi Choliche
Nayereh Mortazavi
Shadi Botshekan
Comparison of urinary KIM-1 and NGAL and plasma creatinine in patients undergoing coronary artery bypass graft surgery
description Introduction: Serum creatinine level is currently being used as an indicator to detect acute kidney injury (AKI) after cardiac surgery, which is delayed and unreliable. Objectives: This study was conducted to determine the AKI in patients undergoing coronary artery bypass graft (CABG) surgery by measurement of urinary creatinine and plasma kidney injury molecule (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL). Patients and Methods: In this cross-sectional study, 96 patients undergoing CABG were divided based on their serum creatinine level of the fourth day after procedure into two groups of AKI (an increase of creatinine more than 0.3 mg/dl or more than 150 % of its baseline level) and non-AKI. In both groups urinary KIM-1 and urinary NGAL were measured on the first day of surgery (first 24 h). Results: No significant difference was observed in baseline creatinine between the two groups (P>0.05). However postoperative serum creatinine, creatinine changes, urinary NGAL and KIM1 showed significant difference between the groups (P<0.05). Serum creatinine was positively correlated with KIM-1 (r = 0.666, P<0.001) and NGAL (r = 0.660, P<0.001). KIM-1 and NGAL had high ability to detect AKI [area under the ROC (receiver operating characteristic) curve of 0.929 and 0.838, respectively]. The NGAL at cut-off point of 97.4 had 86% sensitivity and 80% specificity and KIM-1 at cut-off point of 14.8 had 84% sensitivity and 89% specificity. Conclusion: KIM-1 and NGAL had high ability to detect AKI. However, KIM-1 had higher detection ability than that of NGAL.
format article
author Maryam Saeedi Ghaheh
Saeed Mardani
Afsaneh Malekpour
Farzaneh Kadkhodaei Elyaderani
Fatemeh Salehi Choliche
Nayereh Mortazavi
Shadi Botshekan
author_facet Maryam Saeedi Ghaheh
Saeed Mardani
Afsaneh Malekpour
Farzaneh Kadkhodaei Elyaderani
Fatemeh Salehi Choliche
Nayereh Mortazavi
Shadi Botshekan
author_sort Maryam Saeedi Ghaheh
title Comparison of urinary KIM-1 and NGAL and plasma creatinine in patients undergoing coronary artery bypass graft surgery
title_short Comparison of urinary KIM-1 and NGAL and plasma creatinine in patients undergoing coronary artery bypass graft surgery
title_full Comparison of urinary KIM-1 and NGAL and plasma creatinine in patients undergoing coronary artery bypass graft surgery
title_fullStr Comparison of urinary KIM-1 and NGAL and plasma creatinine in patients undergoing coronary artery bypass graft surgery
title_full_unstemmed Comparison of urinary KIM-1 and NGAL and plasma creatinine in patients undergoing coronary artery bypass graft surgery
title_sort comparison of urinary kim-1 and ngal and plasma creatinine in patients undergoing coronary artery bypass graft surgery
publisher Society of Diabetic Nephropathy Prevention
publishDate 2021
url https://doaj.org/article/b0dcee415ff94a1cb44f140c8aaedc31
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