Vaccine Protection Against Experimental Challenge Infection with a PPV-27a Genotype Virus in Pregnant Gilts

István Kiss,1 Edit Kovács,1 Zoltán Zádori,2 István Mészáros,2 Attila Cságola,1 Pál Bajnóczi,3 Preben Mortensen,4 Vilmos Palya1 1Ceva-Phylaxia Co. Ltd., Budapest, Hungary; 2Institute for Vete...

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Autores principales:	Kiss I, Kovács E, Zádori Z, Mészáros I, Cságola A, Bajnóczi P, Mortensen P, Palya V
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	ppv k22 strain efficacy ppv-27a Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/b0dfce345d8a470697139b757c6525b0
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spelling	oai:doaj.org-article:b0dfce345d8a470697139b757c6525b02021-12-02T11:31:58ZVaccine Protection Against Experimental Challenge Infection with a PPV-27a Genotype Virus in Pregnant Gilts2230-2034https://doaj.org/article/b0dfce345d8a470697139b757c6525b02020-02-01T00:00:00Zhttps://www.dovepress.com/vaccine-protection-against-experimental-challenge-infection-with-a-ppv-peer-reviewed-article-VMRRhttps://doaj.org/toc/2230-2034István Kiss,1 Edit Kovács,1 Zoltán Zádori,2 István Mészáros,2 Attila Cságola,1 Pál Bajnóczi,3 Preben Mortensen,4 Vilmos Palya1 1Ceva-Phylaxia Co. Ltd., Budapest, Hungary; 2Institute for Veterinary Medical Research, Centre for Agricultural Research, Budapest, Hungary; 3Prophyl Ltd., Mohács, Hungary; 4Ceva Animal Health, Libourne, FranceCorrespondence: István KissCeva-Phylaxia Co. Ltd., Szállás U. 5, Budapest H-1107, HungaryTel +36 1262 9505Fax +36010260 3889Email istvan.kiss@ceva.comBackground/Introduction: Porcine parvovirus (PPV), the causative agent of severe reproductive failures in pigs, is present worldwide. The witnessed spread of the virulent 27a type PPV strains since its recognition raised concerns about the efficacy of the available commercial vaccines.Methods: To address this question, vaccinated pregnant gilts were challenged with a PPV-27a-like virus strain and parameters related to vaccine efficacy were compared.Results: The K22 vaccine strain of Parvoruvax® (PVX) was characterized as “Kresse-like” based on the epitope mapping data. Vaccination of the gilts induced a low level of antibody responses. Based on foetal mortality, the number of sows which had challenge virus-affected foetuses, the percent of PPV positive piglets/litters plus their PPV genome and viral load PVX outscored the other vaccinated groups.Conclusion: Stronger protection was provided by the “Kresse-like” K22 PPV strain-based vaccine than by the NADL-2 and NADL-like strain-based commercial vaccines against a PPV-27a cluster strain challenge. Vaccine-induced antibody levels as measured pre-challenge were not found to be an accurate indicator of protection.Keywords: PPV, K22 strain, efficacy, PPV-27aKiss IKovács EZádori ZMészáros ICságola ABajnóczi PMortensen PPalya VDove Medical Pressarticleppvk22 strainefficacyppv-27aVeterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol Volume 11, Pp 17-24 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	ppv k22 strain efficacy ppv-27a Veterinary medicine SF600-1100
spellingShingle	ppv k22 strain efficacy ppv-27a Veterinary medicine SF600-1100 Kiss I Kovács E Zádori Z Mészáros I Cságola A Bajnóczi P Mortensen P Palya V Vaccine Protection Against Experimental Challenge Infection with a PPV-27a Genotype Virus in Pregnant Gilts
description	István Kiss,1 Edit Kovács,1 Zoltán Zádori,2 István Mészáros,2 Attila Cságola,1 Pál Bajnóczi,3 Preben Mortensen,4 Vilmos Palya1 1Ceva-Phylaxia Co. Ltd., Budapest, Hungary; 2Institute for Veterinary Medical Research, Centre for Agricultural Research, Budapest, Hungary; 3Prophyl Ltd., Mohács, Hungary; 4Ceva Animal Health, Libourne, FranceCorrespondence: István KissCeva-Phylaxia Co. Ltd., Szállás U. 5, Budapest H-1107, HungaryTel +36 1262 9505Fax +36010260 3889Email istvan.kiss@ceva.comBackground/Introduction: Porcine parvovirus (PPV), the causative agent of severe reproductive failures in pigs, is present worldwide. The witnessed spread of the virulent 27a type PPV strains since its recognition raised concerns about the efficacy of the available commercial vaccines.Methods: To address this question, vaccinated pregnant gilts were challenged with a PPV-27a-like virus strain and parameters related to vaccine efficacy were compared.Results: The K22 vaccine strain of Parvoruvax® (PVX) was characterized as “Kresse-like” based on the epitope mapping data. Vaccination of the gilts induced a low level of antibody responses. Based on foetal mortality, the number of sows which had challenge virus-affected foetuses, the percent of PPV positive piglets/litters plus their PPV genome and viral load PVX outscored the other vaccinated groups.Conclusion: Stronger protection was provided by the “Kresse-like” K22 PPV strain-based vaccine than by the NADL-2 and NADL-like strain-based commercial vaccines against a PPV-27a cluster strain challenge. Vaccine-induced antibody levels as measured pre-challenge were not found to be an accurate indicator of protection.Keywords: PPV, K22 strain, efficacy, PPV-27a
format	article
author	Kiss I Kovács E Zádori Z Mészáros I Cságola A Bajnóczi P Mortensen P Palya V
author_facet	Kiss I Kovács E Zádori Z Mészáros I Cságola A Bajnóczi P Mortensen P Palya V
author_sort	Kiss I
title	Vaccine Protection Against Experimental Challenge Infection with a PPV-27a Genotype Virus in Pregnant Gilts
title_short	Vaccine Protection Against Experimental Challenge Infection with a PPV-27a Genotype Virus in Pregnant Gilts
title_full	Vaccine Protection Against Experimental Challenge Infection with a PPV-27a Genotype Virus in Pregnant Gilts
title_fullStr	Vaccine Protection Against Experimental Challenge Infection with a PPV-27a Genotype Virus in Pregnant Gilts
title_full_unstemmed	Vaccine Protection Against Experimental Challenge Infection with a PPV-27a Genotype Virus in Pregnant Gilts
title_sort	vaccine protection against experimental challenge infection with a ppv-27a genotype virus in pregnant gilts
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/b0dfce345d8a470697139b757c6525b0
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Vaccine Protection Against Experimental Challenge Infection with a PPV-27a Genotype Virus in Pregnant Gilts

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