Identification of a conserved virion-stabilizing network inside the interprotomer pocket of enteroviruses

Flatt, Butcher and colleagues use cryo-EM to report on coxsackieviruses B3 and B4 bound to different capsid binders. Comparative analysis revealed the residues that form a conserved virion stabilizing network at the interprotomer site, and showed the small molecule properties that allow anchoring in...

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Autores principales:	Justin W. Flatt, Aušra Domanska, Alma L. Seppälä, Sarah J. Butcher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b0e01d6d04a2456598c35c7e5e56a1fa
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spelling	oai:doaj.org-article:b0e01d6d04a2456598c35c7e5e56a1fa2021-12-02T13:33:44ZIdentification of a conserved virion-stabilizing network inside the interprotomer pocket of enteroviruses10.1038/s42003-021-01779-x2399-3642https://doaj.org/article/b0e01d6d04a2456598c35c7e5e56a1fa2021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01779-xhttps://doaj.org/toc/2399-3642Flatt, Butcher and colleagues use cryo-EM to report on coxsackieviruses B3 and B4 bound to different capsid binders. Comparative analysis revealed the residues that form a conserved virion stabilizing network at the interprotomer site, and showed the small molecule properties that allow anchoring in the pocket to inhibit virus disassembly.Justin W. FlattAušra DomanskaAlma L. SeppäläSarah J. ButcherNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Justin W. Flatt Aušra Domanska Alma L. Seppälä Sarah J. Butcher Identification of a conserved virion-stabilizing network inside the interprotomer pocket of enteroviruses
description	Flatt, Butcher and colleagues use cryo-EM to report on coxsackieviruses B3 and B4 bound to different capsid binders. Comparative analysis revealed the residues that form a conserved virion stabilizing network at the interprotomer site, and showed the small molecule properties that allow anchoring in the pocket to inhibit virus disassembly.
format	article
author	Justin W. Flatt Aušra Domanska Alma L. Seppälä Sarah J. Butcher
author_facet	Justin W. Flatt Aušra Domanska Alma L. Seppälä Sarah J. Butcher
author_sort	Justin W. Flatt
title	Identification of a conserved virion-stabilizing network inside the interprotomer pocket of enteroviruses
title_short	Identification of a conserved virion-stabilizing network inside the interprotomer pocket of enteroviruses
title_full	Identification of a conserved virion-stabilizing network inside the interprotomer pocket of enteroviruses
title_fullStr	Identification of a conserved virion-stabilizing network inside the interprotomer pocket of enteroviruses
title_full_unstemmed	Identification of a conserved virion-stabilizing network inside the interprotomer pocket of enteroviruses
title_sort	identification of a conserved virion-stabilizing network inside the interprotomer pocket of enteroviruses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b0e01d6d04a2456598c35c7e5e56a1fa
work_keys_str_mv	AT justinwflatt identificationofaconservedvirionstabilizingnetworkinsidetheinterprotomerpocketofenteroviruses AT ausradomanska identificationofaconservedvirionstabilizingnetworkinsidetheinterprotomerpocketofenteroviruses AT almalseppala identificationofaconservedvirionstabilizingnetworkinsidetheinterprotomerpocketofenteroviruses AT sarahjbutcher identificationofaconservedvirionstabilizingnetworkinsidetheinterprotomerpocketofenteroviruses
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Identification of a conserved virion-stabilizing network inside the interprotomer pocket of enteroviruses

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